A5000201158- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Invertebrate Immune Response Mechanisms
- Plant and animal studies
- Autism Spectrum Disorder Research
- Biochemical Analysis and Sensing Techniques
- Insect Utilization and Effects
- Ion Channels and Receptors
- Advanced Memory and Neural Computing
- Fermentation and Sensory Analysis
- Functional Brain Connectivity Studies
- Animal Behavior and Reproduction
- Chromosomal and Genetic Variations
- Postharvest Quality and Shelf Life Management
University of California, Santa Barbara
2020-2024
California Institute of Technology
2022
Neuroelectronics Research Flanders
2014-2021
VIB-KU Leuven Center for Cancer Biology
2014-2021
KU Leuven
2013-2021
Center for Human Genetics
2016
Instituto Politécnico Nacional
2015
VIB-KU Leuven Center for Microbiology
2013
IMEC
2013
Yeast cells produce various volatile metabolites that are key contributors to the pleasing fruity and flowery aroma of fermented beverages. Several these metabolites, including isoamyl acetate ethyl acetate, produced by a dedicated enzyme, alcohol acetyl transferase Atf1. However, despite much research, physiological role ester formation in yeast remains unknown. Using combination molecular biology, neurobiology, behavioral tests, we demonstrate deletion ATF1 alters olfactory response...
Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these come at a high metabolic price (McKean Lazzaro, 2011, Kominsky et al., 2010), avoiding before may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important system cues (Abbas 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior infection. Here we show that Drosophila melanogaster display strong aversive LPS gustatory...
The retrosplenial cortex plays a role in associating familiar environmental contexts with appropriate motor actions.
Abstract Cortical neurons store information across different timescales, from seconds to years. Although stability is variable regions, it can vary within a region as well. Association areas are known multiplex behaviorally relevant variables, but the of their representations not well understood. Here, we longitudinally recorded activity neuronal populations in mouse retrosplenial cortex (RSC) during performance context-choice association task. We found that exhibits levels days. Using...
Ongoing neural activity has been observed across several brain regions and is thought to reflect the internal state of brain. Yet, it important understand how ongoing interacts with sensory experience shapes representations. Here, we show that projection neurons fruit fly antennal lobe exhibit spatiotemporally organized activity. After repeated exposure odors, observe a gradual cumulative decrease in amplitude number calcium events occurring absence odor stimulation, as well reorganization...
ABSTRACT During navigation, animals often use recognition of familiar environmental contexts to guide motor action selection. The retrosplenial cortex (RSC) receives inputs from both visual and subcortical regions required for spatial memory, projects planning regions. However, it is not known whether RSC important associating with specific actions. Here, we test this possibility by developing a task in which trajectories are chosen based on the context. We find that mice exhibit...
ABSTRACT Ongoing neural activity has been observed across several brain regions and thought to reflect the internal state of brain. Yet, it is not fully understood how ongoing interacts with sensory experience shape representations. Here, we show that projection neurons fruit fly antennal lobe exhibit spatiotemporally organized in absence odor stimulation. Upon repeated exposure odors, observe a gradual long-lasting decrease amplitude frequency spontaneous calcium events, as well...
ABSTRACT Cortical neurons store information across different timescales, from seconds to years. Although stability is variable regions, it can vary within a region as well. Association areas are known multiplex behaviorally relevant variables, but the of their representations not well understood. Here, we longitudinally recorded activity neuronal populations in retrosplenial cortex (RSC) during performance context-choice association task. We found that exhibits levels days. Using linear...