A5072080899- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Amphibian and Reptile Biology
- Sympathectomy and Hyperhidrosis Treatments
- Functional Brain Connectivity Studies
- Insect and Arachnid Ecology and Behavior
- Vestibular and auditory disorders
- Animal Behavior and Reproduction
- Olfactory and Sensory Function Studies
- Neurological Complications and Syndromes
- Pain Mechanisms and Treatments
- Wildlife Ecology and Conservation
- Ophthalmology and Eye Disorders
- Spider Taxonomy and Behavior Studies
- Transcranial Magnetic Stimulation Studies
- Ion Transport and Channel Regulation
- Neuroscience of respiration and sleep
- Law and Political Science
- Environmental DNA in Biodiversity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Turtle Biology and Conservation
- Renal function and acid-base balance
- Vascular Malformations Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
Bielefeld University
2020-2025
University Medical Center Hamburg-Eppendorf
2012-2021
Universität Hamburg
2012-2021
Eppendorf (Germany)
2015
Functional imaging using positron emission tomography and later functional magnetic resonance revealed a particular brainstem area that is believed to be specifically activated in migraine during, but not outside of the attack, consequently has been coined 'migraine generator' . However, pathophysiological concept behind this term undisputed typical premonitory symptoms such as fatigue yawning, also association attacks circadian menstrual cycles, all make hypothalamus possible regulating...
To identify pathophysiologic mechanisms of migraine chronification using a recently standardized protocol for high-resolution brainstem imaging trigeminal nociceptive stimulation.Eighteen episodic migraineurs (EMs), 17 chronic (CMs), and 19 healthy controls (HCs) underwent painful ammonia stimulation the left nostril in 3T MRI scanner. Functional images were acquired with brainstem-optimized echo-planar imaging.We detected significantly stronger activation anterior right hypothalamus CMs...
Abstract Background Certain environmental stimuli are frequently reported as typical triggers of migraine pain. Whether these so-called independent precipitators pain or mere symptoms the premonitory phase remains to be elucidated. Methods In this retrospective cohort study 1010 patients a tertiary headache center we assessed frequency common trigger factors, and accompanying well basic characteristics demographic data. Results Premonitory with an onset 2 more hours prior were present in...
Objective Although migraine is defined by the headache and headache‐associated symptoms, true beginning of a attack lies in premonitory phase. To understand generation attacks, one needs to investigate phase before starts. The characterized well‐described complex symptoms. Its duration, however, not clearly defined, there are no biomarkers help define when this Methods Here, we used functional magnetic resonance imaging (MRI) elucidate duration spontaneous human attacks. Because attacks...
In collaboration with some of the leading headache centres in Germany, Switzerland and Austria, we have established new guidelines for treatment migraine attacks prevention migraine. A thorough literature research last 10 years has been basis current recommendations. At beginning, present therapeutic novelties, followed by a summary all After an introduction, cover topics like drug therapy practical experience, non-effective medication, prevention, interventional methods, non-medicational...
The aim of the current study was to identify typical alterations in resting state connectivity within different stages migraine cycle and thus explore task-free mechanisms headache attack generation migraineurs.Recent evidence pathophysiology suggests that hours even days before certain changes brain activity take place, ultimately leading an attack. Here, we investigate onset using functional magnetic resonance imaging (fMRI).Nine episodic migraineurs underwent daily for a minimum period 30...
A network of kinases, including WNKs, SPAK and Sgk1, is critical for the independent regulation K+ Na+ transport in distal nephron. Angiotensin II thought to act as a key hormone orchestrating these kinases switch from secretion during hyperkalaemia reabsorption intravascular volume depletion, thus keeping disturbances electrolyte blood pressure homeostasis at minimum. It remains unclear, however, how are regulated high intake, which associated with suppressed angiotensin levels tubular...
Abstract In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2’s dose-response function the human hippocampus, we pharmacologically increased E2 levels 125 naturally cycling women (who were their low-hormone menstruation phase) to physiological (equivalent menstrual cycle peak) and supraphysiological during early pregnancy) concentrations...
Abstract Assortative mating can play a major role in the divergence of population with gene flow. In fire salamander near Bonn, Germany, larvae differ genetically according to habitat type they are found in, i.e. ponds or streams. Neither sound nor vision source for assortative salamanders, but it is known that females discriminate between sexes and types males based on chemical cues. The adults share same terrestrial which leads question whether there type-specific fingerprint already...
Background Conspicuous color patterns are traditionally believed to advertise the toxicity of prey potential predators. However, many aposematic species show drastic variation in coloration, indicating possibility other functions coloration. To study these functions, we can investigate influence inherent (e.g., sex) and external factors climate) on variation. We used European fire salamander (Salamandra salamandra) drivers yellow proportion their dorsal black coloration based citizen science...
ABSTRACT Anthropogenic activities threaten many wildlife populations by increasing mortality rates, making it crucial to identify the locations and causes of inform conservation actions. Technological advancements, such as GPS satellite tracking, enable precise recording movements. High‐resolution data from devices can facilitate rapid carcass recovery provide insights into tagged individuals. Obtaining required information determine these is complex, standardized approaches overcome...
<h3>Objectives:</h3> The aim of the study was to determine whether various transient sensory and neuropsychological symptoms (SNS) were associated with migraine using a custom questionnaire. <h3>Methods:</h3> In this hypothesis-generating case-control study, frequencies SNS in 219 patients (149 without aura 70 aura) compared 161 age- sex-matched healthy controls Patients from tertiary academic headache center Hamburg contacted by regular mail. Healthy history recruited means screening...
Functional neuroimaging studies are an indispensable tool in headache research and have greatly contributed to our understanding of migraine pathophysiology. The past two decades identified the brainstem as target region interest pathophysiology: Recent evidence suggests that certain areas central nervous system especially periodically change activity during different stages cycle. Additionally, number resting‐state functional MRI has increased recent years. Three future trends can be...
<h3>Objective</h3> The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the and trigeminonociceptive system. Visual stimulation chronic migraineurs on level of brainstem might lead enhanced activity within spinal trigeminal nucleus (sTN) main site pain processing area. <h3>Methods</h3> Eighteen episodic (EM), 17 (CM), 19 healthy controls...
We investigated changes of after-image duration in migraineurs and healthy controls (HCs) throughout the migraine cycle to depict excitatory/inhibitory equilibrium within visual cortex. Forty-seven episodic (EMs) 39 chronic (CMs; interictal) were compared 34 HCs for duration. Additionally, seven EMs every consecutive day over 20 32 days using identical paradigm cycle. Interictally, was shorter HCs, but significantly longer ictal interictal phase. These data suggest an altered migraineurs,...
Introduction The response to indomethacin is an important feature for the diagnosis of hemicrania continua. Case description We report case a 34-year-old female patient with one-year history strictly unilateral continuous headache accompanying ipsilateral autonomic symptoms. As diagnostic testing was unremarkable, continua suspected. A dose 150 mg indomethacin/day reduced by 80%. Although increase 225 mg/day led further reduction headaches, new onset moderate severe pulsating migrainous...
Introduction While inhalation of high-flow 100% oxygen is highly effective in cluster headache, studies on its efficacy migraine are sparse and controversial. Case We report the case a 22-year-old patient with an eight-year history strictly unilateral without aura but cranial autonomic symptoms. She repeatedly responded completely to pure within 15 min suffered from recurrence attacks 30 after discontinuation. Discussion In line experimental animal studies, this suggests clinically relevant...