About
Contact & Profiles
A5018146685
Research Areas
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Estrogen and related hormone effects
- Hormonal and reproductive studies
Saarland University
2021
Mitochondrial cytochromes P450 presumably originated from a common microsomal ancestor. However, it is still unknown how ancient mitochondrial P450s were able to retain their oxygenase function following relocation the matrix and later emerged as enzymes specialized for steroid hormone biosynthesis in vertebrates. Here, we used approach of ancestral sequence reconstruction (ASR) resurrect CYP11A1 characterize unique biochemical properties. Two variants, CYP11A_Mammal_N101 CYP11A_N1, well an...
10.1111/febs.16054
article
EN
cc-by-nc-nd
FEBS Journal
2021-06-06
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