Jennifer Spengler

ORCID: 0000-0002-2271-9628
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About
Contact & Profiles
Research Areas
  • Neuroblastoma Research and Treatments
  • Turtle Biology and Conservation
  • Neurofibromatosis and Schwannoma Cases
  • Cancer Genomics and Diagnostics
  • Virus-based gene therapy research
  • Reproductive biology and impacts on aquatic species
  • Epigenetics and DNA Methylation
  • Zebrafish Biomedical Research Applications
  • Hemispheric Asymmetry in Neuroscience
  • Congenital heart defects research
  • Ubiquitin and proteasome pathways
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Protein Degradation and Inhibitors

EpiCypher (United States)
2024

Stowers Institute for Medical Research
2019-2021

Millersville University
2019

University of Pittsburgh
2018

The precise regulation of chromatin composition is critical to gene expression and cellular identity, thus a key component in development disease. Robust assays study features, including histone post-translational modifications (PTMs) chromatin-associated proteins (e.g., transcription factors or PTM readers), are essential understand their function identify novel therapeutic strategies. To this end, Cleavage Under Targets Release Using Nuclease (CUT&RUN) has emerged as powerful tool for...

10.1101/2024.12.03.626419 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-12-06
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