A5086290125- Circular RNAs in diseases
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Phytochemical Studies and Bioactivities
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Natural product bioactivities and synthesis
- Child Nutrition and Water Access
- Stress Responses and Cortisol
- Antioxidant Activity and Oxidative Stress
- Infant Nutrition and Health
- Biotechnology and Related Fields
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- Bone health and osteoporosis research
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetically Modified Organisms Research
- Dialysis and Renal Disease Management
Universidade Federal do Rio Grande do Norte
2016-2023
University of California, San Diego
2023
Hospital Universitário Onofre Lopes
2018
Universidade de São Paulo
2018
OBJECTIVES: Inflammatory molecules play a role in the development of atherosclerosis, which is primary origin cardiovascular disorders.However, to best our knowledge, no study has attempted investigate relationship between these circulating and prediction risk.The present aimed relationships vascular cell adhesion molecule-1, intercellular E-selectin matrix metalloproteinase 9 serum concentrations with extent coronary lesions.METHODS: Seventy-four individuals who were undergoing angiography...
Until January 2023, Brazil recorded 37 million COVID-19 cases despite the decrease in mortality due to mass vaccination efforts against COVID-19. The infection continues challenge researchers and health professionals with persistent symptoms onset manifestations after acute phase of disease, namely Post-Covid Condition (PCC). Being one countries highest rate, must prepare for a growing number patients chronic consequences Longitudinal studies that follow over extended periods are crucial...
LAMP2 is a ubiquitously expressed protein critical for autophagy. Alternative splicing gives rise to three isoforms. However, the roles of major isoforms in heart are not known. To address this knowledge gap, we generated lamp2a and lamp2b knockout (KO) mice investigate role these function Deletion either Lamp2a or Lamp2b did alter cardiac structure function. Lack all led increased fibrosis reduced survival during pressure overload, which were observed KO mice. Also, LAMP2B loss affect...
Abstract Vitamin D supplementation is widely used. However, there no consensus on the use and dosage of this supplement existing recommendations arise from studies based benefits that nutrient can facilitate in bones. In addition, individual genetics influence response to supplementation, therefore, research involving monozygotic twins aims reduce these differences phenotypic responses. The objective randomised controlled study examine effect vitamin body composition expression receptor (...
Hecogenin is a sapogenin found in Agave species high quantities and responsible for the many therapeutic effects of these medicinal plants. In addition, this compound also widely used pharmaceutical industry as precursor synthesis steroidal hormones anti-inflammatory drugs. Despite being used, little known about its toxicological properties. Therefore, present study aimed to investigate cytotoxic, genotoxic mutagenic on HepG2 cells. Cytotoxicity was analyzed using MTT test. Then, potentials...
Acute ST-elevation myocardial infarction (STEMI) can lead to adverse cardiac remodeling, resulting in left ventricular systolic dysfunction (LVSd) and heart failure. Epigenetic regulators, such as microRNAs, may be involved the physiopathology of LVSd.This study explored microRNAs peripheral blood mononuclear cells (PBMC) post-myocardial patients with LVSd.Post-STEMI were grouped having (LVSd, n = 9) or not LVSd (non-LVSd, 16). The expression 61 was analyzed PBMC by RT-qPCR differentially...
Background: Vitamin E supplementation might represent an efficient strategy to increase the vitamin content in milk. The present study aimed evaluate impact of with 800 IU RRR-alpha-tocopherol on alpha-tocopherol milk and factors associated E. Methods: Randomized clinical trial 79 lactating women from Brazil, who were assigned control group, or supplemented group (800 RRR-alpha-tocopherol). Milk serum collected between 30 90 days after delivery (collection 1), next day 2). Alpha-tocopherol...
Background and aims : Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease progression atherosclerosis. This study aimed at investigating relationship serum levels alpha-tocopherol retinol with extent coronary lesions patients artery disease. Methods . Patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>177</mml:mn></mml:mrow></mml:math>) aged 30–74 years, who underwent their...
Abstract Members of the triggering receptor expressed on myeloid cells (TREM) family are associated with atherosclerosis risk and progression. TREML4 is upregulated in early phase acute coronary syndrome. We investigated relationship between mRNA expression 13 genes blood leukocytes, polymorphisms, artery lesion extension (Friesinger index) patients disease (CAD) (n = 137). rs2803495 (A > G) rs2803496 (T C) variants leukocyte were analysed by qRT-PCR. was higher major lesions than...
TREML4 and other members of the triggering receptor expressed in myeloid cell family are associated with a risk atherosclerosis progression coronary artery disease, acute syndrome, calcification. Herein, relationship between expression its polymorphisms (rs2803495 rs280396) was evaluated patients subclinical (n = 340) heart failure post-acute myocardial infarction (MI) 68) for first time. variants rs2803495 (A > G) rs2803496 (T C) leukocyte mRNA analyzed by qRT-PCR. The G allele (OR 8.01, CI...
Chronic kidney disease (CKD) increases cardiovascular (CVD) risk development. However, the mechanisms of reduced function with CVD are unclear. This study aimed to investigate association between and Framingham score (FRS) in participants traditional factors normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² an admixed population Brazil. The were divided into three groups according FRS: low group 0% <10%, moderate ≥10% 20% high >20%. eGFR was calculated using Kidney...
Abstract Until January 2023, Brazil recorded 37 million COVID-19 cases despite the decrease in mortality after mass vaccination efforts for SARS-CoV-2. The infection continues to challenge researchers and health professionals with persistent symptoms onset manifestations acute phase of disease, namely Post-Covid Condition (PCC). Being one countries highest rate, must prepare many patients chronic consequences COVID-19. Longitudinal studies that follow over extended periods are crucial...