Proteinuria and systemic hypertension are well recognised risk factors in chronic renal failure (CRF). They consequences of disease but also lead to a further loss functional kidney tissue. The objectives this study were investigate the associations between proteinuria, glomerular filtration rate (GFR) dogs with naturally occurring non-renal diseases, determine whether proteinuria associated shorter survival times CRF. Measurements exogenous creatinine plasma clearance (ECPC), urine...

The potential toxicity of aerosolized glycerol was studied by 2-wk and 13-wk nose-only inhalation exposures in Sprague-Dawley-derived (Cr1:CD) rats. In the first study, 10 ratslsedgroup received 6 h/day for 2 wk over a 14-day period to mean aerosol concentrations 0, 7.00 ± 0.08, 1.93 0.123, or 3.91 0.458 mg glycerol/l filtered room air: Animals were observed signs twice daily, weighed at 2– 3-day intervals, diet consumption recorded weekly intervals. All rats underwent complete necropsy,...

Exposure of hamsters to CoO aerosol (10 g/L, 7 hrs./day, 5 days/week) caused pneumoconiosis but affected neither the life span nor incidence other than pneumoconiotic lesions. No carcinogenic effects were observed. While cigarette smoke exposures significantly increased certain types lesions including tumors, they also smoke-exposed animals significantly. The latter phenomenon may account for higher tumor in animals. effect on and degree was mean body weights groups reduced.

A human kit for cystatin C determination was evaluated use with canine sera. reference range also established. The association between and glomerular filtration rate (GFR) in 60 dogs various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. correlation ECPC (correlation coefficient [r] = −0.630; P<0.001) stronger than the serum (r −0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence concentration. Test sensitivity...

Abstract Chronic inhalation of NiO and cigarette smoke (CS) by hamsters eventually caused pneumoconiosis whose development was unaffected CS. No carcinogenic or cocarcinogenic effect CS observed. exposure increased laryngeal lesions, reduced body weight, lifespan.

Dogs with hypoadrenocorticism (HA) frequently show signs of gastrointestinal disease (SGD). The prevalence dogs presented for chronic SGD HA is unknown.The aims this study were to determine the in and identify clinical laboratory variables population.One hundred fifty-one SGD.In multicentered a standardized workup was performed prospectively enrolled > 3 weeks duration. Basal serum cortisol concentration measured every dog ACTH stimulation test (ACTHST) if basal <3 μg/dL.Basal μg/dL 80/151...

Summary Objective: Measurement of rectal temperature is the most common method and considered gold standard for obtaining body in dogs. So far, no study has been performed comparing agreement between auricular measurements a large case series. The purpose was to assess measurement normothermic, hypothermic, hyperthermic dogs with consideration different environmental conditions ear conformations. Materials methods: Reference values both methods were established using 62 healthy Three hundred...

Two siblings, a 6-month-old sexually intact male weighing 2.5 kg (cat 1) and female 2) British Shorthair cat 2.3 kg, were examined because of 3-week history polyuria, lethargy laboured breathing. One year previously, another sibling 3) had been presented similar, yet more severe, clinical signs at the age 5 months. Physical examination revealed lethargy, dehydration polypnoea with slightly increased inspiratory effort. Diagnostic investigation severe hypercalcaemia (cats 1–3), renal...

Feline hyperthyroidism is a common endocrine disorder in older cats. Previous studies have identified nutritional imbalances, thyroid-disrupting compounds, increasing age and being non-purebred as risk factors but the final trigger remains unknown. The purpose of this prospective study was a) to determine hospital prevalence client-owned cat population Southern Germany, b) exploit how frequently diagnosed after initial clinical suspicion c) putative intrinsic extrinsic from cats' signalment...

Hereditary hypothyroidism represents a concern for dog breeders; thus, surveillance programs have been established several breeds.Thyroid profiles (total thyroxine (TT4), thyrotropin (thyroid stimulating hormone (TSH)), and thyroglobulin autoantibodies (TgAA)) collected as part of breed program in Eurasians (2009-2017) were retrospectively analyzed. The study included data from 1,501 German breeding club. Classification was exclusively based on laboratory data. Hypothyroidism defined...

Abstract Case Description —A 2-year-old 38.9-kg (85.58-lb) sexually intact male German Shepherd Dog was examined because of a 4-month history severe nasal swelling and mucosa congestion. The signs were slowly progressive. Clinical Findings —Physical examination revealed that the dorsal aspect dog's nose swollen hard. Mucous membranes in both nostrils hyperemic edematous. Diagnostic investigation osteolysis pyogranulomatous rhinitis nasopharyngitis attributable to blastomycosis. Treatment...

Adrenal function may be altered in animals with hyperthyroidism. The aim of the study was to assess adrenal hyperthyroid cats (n = 17) compared healthy 18) and chronic diseases 18). evaluated by adrenocorticotropic hormone (ACTH) stimulation test urinary cortisol creatinine ratio (UCCR) determined. Length width both glands were measured via ultrasound. Hyperthyroid had significantly higher levels before after ACTH than other groups. However, UCCR not elevated cats. size different from those...

It is unknown how dogs with hyperadrenocorticism (HAC) respond to vaccination. This study measured antibodies against canine parvovirus (CPV) in HAC treated trilostane before and after CPV vaccination, compared the immune response that from healthy dogs. Eleven HAC, age-matched control (n = 31) received a modified-live vaccine. Antibodies were determined on days 0, 7, 28 by hemagglutination inhibition. Univariate analysis was used compare of Pre-vaccination (≥10) detected 100% (11/11; 95%...

Trilostane is the recommended medical treatment for dogs with hyperadrenocorticicm (HAC). The objective of this study was to investigate association between ACTH stimulation test (ACTHST) results, and relevant clinical signs, in treated trilostane. A disease-specific questionnaire developed, which included owner's assessment polydipsia, polyuria, polyphagia, panting, satisfaction treatment, based on a 5-response category rating scale. Forty-nine HAC were prospectively enrolled. Dogs grouped...

Measurement of total thyroxine (T4) is the first testing step in work-up thyroid disease small animals. We evaluated an enzyme-linked fluorescent assay (ELFA) as in-house method to measure T4 cats and dogs. compared concentration sera 122 176 dogs measured by ELFA with enzyme immunoassay (EIA) assess concordance 2 methods. Bias was −11.4% 1.4%. Using Bland–Altman plots, limits agreement were −81.5 58.7% −71.4 74.4% Imprecision calculated for both Intra- interassay coefficients variation...

Zusammenfassung Eine 2 Jahre alte kastrierte Epagneul-Breton-Hündin wurde wegen Ekchymosen bei ungestörtem Allgemeinbefinden vorgestellt. Die klinische Untersuchung ergab zusätzliche Petechien sowie ein Hämatom. Auslandsaufenthalte inkludierten Italien und Dänemark. Labordiagnostisch fielen eine mittelgradige Thrombozytopenie, verlängerte Gerinnungszeiten (PT, aPTT, TT) erhöhte D-Dimer-Konzentration. initiale Therapie umfasste Plasmatransfusionen, Infusion Doxycyclinund Famotidingabe....