A5065917392- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Microbial Natural Products and Biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Biological Activities
- Coral and Marine Ecosystems Studies
- Synthetic Organic Chemistry Methods
- Fungal Biology and Applications
- Analytical Chemistry and Chromatography
- Fungal Infections and Studies
- Sesquiterpenes and Asteraceae Studies
- Bacterial Identification and Susceptibility Testing
- Molecular Sensors and Ion Detection
- Fluorine in Organic Chemistry
- Phytochemical compounds biological activities
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Molecular spectroscopy and chirality
- Metabolomics and Mass Spectrometry Studies
- Asymmetric Synthesis and Catalysis
National Cancer Institute
2023-2024
Universidad Nacional Autónoma de México
2019-2022
The continuing emergence of antibiotic-resistant microbes highlights the need for identification new chemotypes with antimicrobial activity. One most prolific sources molecules has been systematic screening natural product samples. National Institute Allergy and Infectious Diseases Cancer here report a large screen 326,656 partially purified fractions against panel four microbial pathogens, resulting in >3000 antifungal and/or antibacterial A small sample these active was further chemical...
Pyrrole-containing natural products form a large group of structurally diverse compounds that occur in both terrestrial and marine organisms. In the present study formation trideuteromethylated artifacts pyrrole-containing was investigated, focusing on discorhabdins. Three deuterated discorhabdins, 1, 3, 5, were identified to be isolation procedure caused by presence DMSO-d6 during NMR sample preparation handling. additional semisynthetic derivatives, 7–9, made investigation mechanism...
Lippia species share various pharmacological activities and are used in traditional cooking medicine worldwide. Combined chromatographic techniques such as column chromatography, high-performance liquid countercurrent chromatography led to the purification of two new antifungal phenylpropanoid glycosides, lippiarubelloside A (1) B (2), by bioactivity-directed fractionation an ethanol-soluble extract from rubella, addition known active related compounds forsythoside (3), verbascoside (4),...
Cytotoxic 6-heptyl-5,6-dihydro-2H-pyran-2-ones are chemical markers of Hyptis (Lamiaceae) and responsible for some the therapeutic properties species with relevance to traditional medicine. The present investigation describes isolation known pectinolides A–C (1–3), in addition new I–M (4–8), from two Mexican collections H. pectinata by HPLC. novel biosynthetically related monticolides A (9) B (10) were also isolated high-speed countercurrent chromatography monticola, an endemic Brazilian...
Structural elucidation of specialized metabolites or natural plant products, especially the stereochemical features chiral bioactive metabolites, is most important stage for all investigations in pharmacognosy and phytochemistry. Numerous methods have been established to solve absolute configuration including direct such as X-ray diffraction, chiroptical spectroscopy, stereo-controlled partial total organic synthesis, chemical correlation by simple reactions derivatization, well indirect...
Antimicrobial bianthrones from Heterometra sp. and their chemical behaviour.