A5068560930- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Schizophrenia research and treatment
- Hip disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Clinical Nutrition and Gastroenterology
- Anesthesia and Sedative Agents
- Medication Adherence and Compliance
- COVID-19 and Mental Health
- Bipolar Disorder and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Healthcare Technology and Patient Monitoring
- Child and Adolescent Psychosocial and Emotional Development
- Blood Pressure and Hypertension Studies
- SARS-CoV-2 and COVID-19 Research
- Pharmacogenetics and Drug Metabolism
- Pediatric Pain Management Techniques
- Long-Term Effects of COVID-19
- Surgical site infection prevention
Hacettepe University
2018-2025
KU Leuven
2024-2025
Hacettepe University Hospital
2024
Erasmus MC
2022
Erasmus University Rotterdam
2022
GTx (United States)
2019
Ankara Atatürk Eğitim ve Araştırma Hastanesi
2015-2016
Abstract Hypoxic‐ischemic encephalopathy (HIE) resulting from perinatal asphyxia presents a substantial risk of mortality and long‐term sequelae in neonates. Therapeutic hypothermia (TH) improves both short‐ outcomes near‐term/term neonates with moderate to severe HIE. While TH often require polypharmacy, the impact covariates on pharmacokinetics pharmacodynamics is only partially described quantified. In this pooled, multicenter retrospective study, longitudinal trends human serum albumin...
The COVID-19 pandemic has captured the mental health discussion worldwide. Examining countries' representation in this could prove instrumental identifying potential gaps terms of ensuring a truly global conversation times crisis.We collected and COVID-19-related journal articles published PubMed 2020. We focused on corresponding authors' countries affiliation to explore representation. also examined these articles' academic impact correlations with their affiliation. Additional journals...
Aim: To develop models that predict the presence of medication errors (MEs) (prescription, preparation, administration, and monitoring) using machine learning in NICU patients. Design: Prospective, observational cohort study randomized with (ML) algorithms. Setting: A 22-bed capacity Ankara, Turkey, between February 2020 July 2021. Results: total 11,908 orders (28.9 orders/patient) for 412 patients (5.53 drugs/patient/day) who received 2,280 prescriptions over 32,925 patient days were...
Abstract Hospitalized newborns have an increased risk of malnutrition and, especially preterm infants, often experience malnutrition-related extrauterine growth restriction (EUGR). The aim this study was to predict the discharge weight and presence gain at with machine learning (ML) algorithms. demographic clinical parameters were used develop models using fivefold cross-validation in software-R a neonatal nutritional screening tool (NNST). A total 512 NICU patients prospectively included...
Adolescents with mental illnesses often struggle adhering to prescribed medication regimens. This study investigates how patient perceptions influence adherence among adolescents psychiatric disorders. It also examines the role of characteristics and medication-related factors on attitudes. The Pediatric Medication Adherence Scale (PMAS)- 9 questions Attitude toward (PAMS)- 18 questions, two reliable self-report scales designed for adolescent population, were used assess negative behaviors...
Background Dexmedetomidine is an alpha-2 adrenergic agonist with sedative, anxiolytic and analgesic effects. Its use in neonatal intensive care units (NICUs) has been increasing the last decade. The aim of this study was to assess safety profile dexmedetomidine identify specific trends its over time. Methods In retrospective observational study, data were collected on all patients who received continuous infusion a level IV NICU Turkey between 2018 2023. Demographic characteristics compared...
Pharmacogenetic studies the influence of inherited characteristics on medication. While different from pharmacogenomics, which is a study entire genome in relation to medication effect, their distinction remains inconsistent, and two terms are used interchangeably. Although potential pharmacogenomics psychiatry apparent its clinical utility suboptimal, uptake recommendations guidelines minimal research into PGx not diverse. This article offers an overview pharmacogenetics (PGx) psychiatry,...
Introduction: Drug-related problems (DRPs) incidence is higher in neonatal intensive care units (NICUs), compared to other pediatric wards due aspects like off-label medications, pharmacokinetic/dynamic variability, or organ dysfunction/immaturity. This study aimed determine whether and what extent a clinical pharmacist intervention improves medication safety prevents DRPs [medication errors (MEs), adverse drug reactions (ADRs), drug-drug interactions (DDIs)]. Methods: A prospective,...
Abstract Background This study aimed to assess medication adherence and demographic, clinical, psychopathological parameters such as quality of life, depression, anxiety levels that can affect pediatrics with Wilson’s Disease (WD). Methods A prospective cohort was conducted at an outpatient clinic in Turkey among pediatric patients (2 18 years) WD between November 2022 April 2023. The Medication Adherence Report Scale (MARS-5) a subjective Possession Ratio (MPR) objective assessment were...
Total hip arthroplasty in dislocated developmental dysplasia is a complex, technically demanding procedure with high complication rates. Anatomic abnormalities and the young age of patients influence results. Restoration anatomic center often requires shortening femur order to avoid over-stretching neurovascular structures. We performed cementless total subtrochanteric transverse osteotomy on 44 hips 31 patients. There were 29 female 2 male The average at time operation was 43.2 (range,...
Despite the risks of venous thromboembolism (VTE) in surgical patients are well defined, primary thromboprophylaxis (TP) can be neglected. The aim this study was to evaluate risk VTE and appropriateness TP assess effects education clinical pharmacy (CP) services.This conducted a total 3 periods (n = 800): pre-education 340), post-education 269) CP intervention period 191) were evaluated. At end period, re-evaluated after given about guidelines on an educative poster posted services...
Critically ill neonates are at greater risk for adverse drug reactions (ADRs). The differentiation of ADRs from associated with organ dysfunction/immaturity or genetic variability is difficult.In this prospective cohort study, each ADR was assessed using newborn-specific severity and probability scales by the clinical pharmacist. Subsequently, a machine learning-based score designed to predict presence in neonates.In 98/412 (23.8%) (56.3%; male) included, 187 (0.42 ADR/patient) were...
Selection of a treatment method in cases unstable, nonarticular distal tibial fractures is still matter discussion. Intramedullary nailing, which "gold standard" for shaft fractures, does not always work this specific transition area between diaphysis and metaphysis. Instead, new minimally invasive techniques with special implants are popular.To determine the functional radiological results treated percutaneous plate osteosynthesis (MIPPO) technique.Retrospective cohort analysis.Thirty MIPPO...
Debridement, antibiotic, and implant retention (DAIR) is an attractive treatment modality after hip hemiarthroplasty (HA) infections. Data about the success of procedure acute onset infections lacking. The aim this study was to analyze clinical outcome associated risk factors.A multicenter, retrospective cohort designed, including 39 patients with prosthetic infection who had undergone debridement irrigation prosthesis retention. primary measure eradication without removal. We also analyzed...
Background: Modulator therapies improve weight and body mass index (BMI) in cystic fibrosis (CF) patients. We aimed to compare the nutritional risk (NRI) adult CF patients receiving modulator (MT) or only non-modulator (conventional) (non-MT). Methods: A single-center prospective cohort study was conducted between June December 2023. The NRI based on gain albumin calculated at beginning end of a 12-week period both groups. This design pragmatic, since it individual patient access MT for 12...
Objectives Given the many medications used to treat novel coronavirus disease (COVID-19) and its comorbidities complications, risk of drug-drug interactions (DDIs) resulting patient harm is concerning. This study aimed shed light on physicians' knowledge potential DDIs related COVID-19 treatment, determine effect an information brief about these their correct response rates, identify factors associated with higher levels DDIs.
COVID-19 infection-related clozapine intoxication could be induce post-infection cytokine release, downregulation of the metabolism in cytochrome P450 (CYP) system through CYP1A2.1 We thought that vaccination would a similar effect on serum concentration clozapine. like to examine potential interaction between and vaccines from different perspectives. Vaccines trigger immune responses alter drugs. As an illustration, mRNA which are BNT162b2 mRNA-1273 brought out strong CD4+ CD8+ T-cell...
Background: Modulator therapies improve weight and body mass index (BMI) in cystic fibrosis (CF) patients. We aimed to compare the nutritional risk (NRI) adult CF patients receiving modulator (MT) or only non-modulator (conventional) (non-MT). Methods: A single-center prospective cohort study was conducted between June-December 2023. The NRI based on gain albumin calculated at beginning end of a 12 weeks period both groups. This design pragmatic, since individual patient access MT for weeks....
A comparison was made of the clinical and radiological results cylindrical fully porous-coated femoral stems (Group A) Zweymüller-type B) used for treatment hip osteoathrosis, secondary to Crowe III IV dysplasia, with total arthroplasty combined transverse shortening osteotomy.This study is a retrospective evaluation 86 hips in 50 patients. Group comprised 43 B hips. During final follow-up evaluation, patients were clinically assessed Harris Hip Score (HHS), Merle d'Aubigne-Postel scale...