Ki‐Bum Sim

ORCID: 0000-0002-2281-1221
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Research Areas
  • Spinal Cord Injury Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Vascular Malformations Diagnosis and Treatment
  • Intracranial Aneurysms: Treatment and Complications
  • Bone and Dental Protein Studies
  • Spinal Dysraphism and Malformations
  • Neurogenesis and neuroplasticity mechanisms
  • Moyamoya disease diagnosis and treatment
  • Meningioma and schwannoma management
  • S100 Proteins and Annexins
  • Congenital heart defects research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Congenital Anomalies and Fetal Surgery
  • Fetal and Pediatric Neurological Disorders
  • Spinal Hematomas and Complications
  • Neurogenetic and Muscular Disorders Research
  • Mesenchymal stem cell research
  • Injury Epidemiology and Prevention
  • Head and Neck Surgical Oncology
  • Cerebrospinal fluid and hydrocephalus
  • Cleft Lip and Palate Research
  • Innovations in Medical Education
  • Signaling Pathways in Disease
  • Assisted Reproductive Technology and Twin Pregnancy
  • Spine and Intervertebral Disc Pathology

Jeju National University
2008-2023

Jeju National University Hospital
2006-2023

Indiana University School of Medicine
2015

Cal Humanities
2010

Nation University
2009

National University
2004-2008

Wooridul Hospital
2001

Bundang Jesaeng Hospital
1999

Seoul National University
1994-1996

Korean Red Cross
1995-1996

Abstract In this study, we evaluated the wall of saccular cerebral aneurysms (SCAs) using two‐dimensional double inversion recovery black‐blood sequence (BBDI). We examined 14 patients with an unruptured SCA (USCA). The BBDI was peripheral‐pulse gated, and acquired during mid‐diastolic period. whether aneurysmal could be visualized BBDI, thickness in neck dome portion aneurysm measured cases acceptable imaging quality. demonstrated USCA walls ten patients. four patients, were poorly...

10.1002/jmri.21942 article EN Journal of Magnetic Resonance Imaging 2009-10-23

Abstract The confluence of sinuses (CS; torcular herophili ) is represented by the junction superior sagittal (SSS), straight (SS), occipital (OS), and two transverse (TS). objective this study was to interpret sinus flow around CS morphological investigation sinuses. This based on visual examination dural venous in region 31 adult cadavers. In inflow zone, we examined direction SSS SS flow. communication extent which outflow communicate with other used diameters determine anatomical...

10.1002/ca.20620 article EN Clinical Anatomy 2008-04-21

To investigate the morphometric characteristics of pituitary gland and diaphragma sellae in Korean adults.Using 33 formaline fixed adult cadavers (23 male, 10 female), measurements were taken at gland. The authors investigated relationship between dura structures surrounding gland, aspects stalk, aspect central opening sellae.The boundary lateral surface medial wall cavernous sinus was formed by thin dural layer capsule. capsule adherent tightly to observed continue from sellae. Mean width,...

10.3340/jkns.2010.47.1.42 article EN cc-by-nc Journal of Korean Neurosurgical Society 2010-01-01

Expression of osteopontin (OPN) was investigated in the spinal cords rats with clip compression injury. Western blot analysis demonstrated that OPN protein increased significantly cord during early stages after The expression partially paralleled by proliferating cell nuclear antigen (PCNA). Immunohistochemical staining showed expressed activated microglia/macrophages core lesions and some astrocytes at periphery lesions. These results indicate increases mainly injury, suggesting is related...

10.1292/jvms.66.1307 article EN cc-by-nc-nd Journal of Veterinary Medical Science 2004-01-01

The expression of two intermediate filaments, nestin and vimentin, was studied in spinal cord injury (SCI) to elucidate their roles the formation glial scars. Rats were sacrificed 1, 4, 7 days after induction compression using an aneurysm clip. affected cords antibodies against vimentin filaments. One day injury, some clusters nestin-positive vessels detected center but few seen other cell types. Vimentin immunostaining cells its level immunoreactivity enhanced ependymal central canal. On 4...

10.4142/jvs.2003.4.2.109 article EN Journal of Veterinary Science 2003-01-01

Intermediate filaments, including nestin and vimentin, are found in specific cell types central nervous system (CNS) tissues, particularly immature glial cells multipotent progenitor cells. In the present study, expression patterns of vimentin spinal cords rats with experimental autoimmune encephalomyelitis (EAE) response containing filaments against acute injury were examined by immunohistochemistry. Nestin immunostaining was only weakly detected vascular endothelial but not any cord normal...

10.4142/jvs.2003.4.1.9 article EN Journal of Veterinary Science 2003-01-01

This study examined the temporal expression of cathepsin D protein and its cellular localization in spinal cords rats after a clip compression injury to determine involvement cord (SCI). Western blot analysis showed significant increase ~31-kDa active form on days 4 7 SCI, while level ~44-kDa inactive remained relatively unchanged. Immunohistochemistry revealed with constitutive most neurons some gliocytes normal be intensely immuno-detected primarily CD68-positive activated...

10.1292/jvms.70.937 article EN cc-by-nc-nd Journal of Veterinary Medical Science 2008-01-01

We report a unique case of bilateral mirror image M1 aneurysms, one which was an unruptured aneurysm arising from the proximal end right middle cerebral artery fenestration with long loop and other ruptured contralateral side. clipped first in three months after operation. The difficulties identifying this unusual vascular anomaly possible problems during surgery at site are discussed review literature.

10.3340/jkns.2010.48.5.434 article EN cc-by-nc Journal of Korean Neurosurgical Society 2010-01-01

A woman suffered from massive blunt injuries in a motor vehicle accident at presumed 4 weeks' gestation, but she successfully carried the fetus for an additional 29 weeks. Premature labor began 33 gestation and live 1,890 g male was delivered. His development normal 12-months postnatal follow-up period. The patient remained persistent vegetative state. Only 12 cases of severely brain-injured pregnant patients who delivered babies have been reported English literature. Such need special...

10.3346/jkms.2001.16.5.669 article EN Journal of Korean Medical Science 2001-01-01

The expression and potential role of phospholipase D1 (PLD1) were studied in the cerebral cortex rats after freeze injury. Histopathologically, cryoinjury, by exposing to a prechilled rod for 1 minute, produced consistent pathological lesions, specifically neuronal death, infiltration macrophages into center reactive astrogliosis at periphery, which caused lesion site become encased. Western blot analysis showed that PLD1 ipsilateral increased significantly during days 3 cryoinjury declined...

10.14670/hh-19.1015 article EN PubMed 2004-10-01

Terminal myelocystocele is a rare form of occult spinal dysraphism in which the hydromyelic caudal cord and subarachnoid space are hemiated through posterior spina bifida. A 1.5 month old boy presented with large lumbosacral mass urinary incontinence. The magnetic resonance imaging, operative findings pathological revealed low lying conus dilated central canal dorsally attached to subcutaneous tissue. Ventral was enlarged herniated laminar defect sacrum. lesion typical terminal...

10.3346/jkms.1996.11.2.197 article EN Journal of Korean Medical Science 1996-01-01

The expression of both cyclooxygenase (COX)‐1 and COX‐2, which are representative enzymes in prostaglandin synthesis, was evaluated the sciatic nerve rats with experimental autoimmune neuritis (EAN).

10.1081/imm-120022973 article EN Immunological Investigations 2003-01-01

The expression of phospholipase D (PLD) in the hearts rats with experimental autoimmune myocarditis (EAM) was studied to elucidate functional role PLD pathogenesis EAM. Western blot analysis showed that level PLD1 isoform significantly increased EAM on days 14, 17 and 21 postimmunization (pi) (P < 0.01; control vs at 14 pi, pi pi). phenotypes cells exhibiting were primarily inflammatory cells, including ED1 positive macrophages, lesions. Some cardiomyocytes also immunoreaction around...

10.1081/imm-120027688 article EN Immunological Investigations 2004-01-01

For the experimental study of neural tube defect (NTD), a surgical model has advantages over other models in few aspects. It causes less functional derangement cells and NTDs can be made selectively by surgery. The authors planned to use for NTD. As first step studies, chronological changes morphology during early postoperative period were investigated using postincubation 3-day chick embryos. objectives this are (1) morphological evaluation as method studies open NTD, (2) observation 24...

10.3346/jkms.1994.9.2.116 article EN Journal of Korean Medical Science 1994-01-01
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