Gebretsadkan Hintsa Tekulu

ORCID: 0000-0002-2301-1453
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Research Areas
  • Injury Epidemiology and Prevention
  • Phytochemistry and Biological Activities
  • Climate Change and Health Impacts
  • Child Nutrition and Water Access
  • Trauma and Emergency Care Studies
  • Ethnobotanical and Medicinal Plants Studies
  • Diverse Scientific Research Studies
  • Phytochemicals and Medicinal Plants
  • Medication Adherence and Compliance
  • Natural Antidiabetic Agents Studies
  • Obesity, Physical Activity, Diet
  • Malaria Research and Control
  • Pharmaceutical Practices and Patient Outcomes
  • Advances in Cucurbitaceae Research
  • Vaccine Coverage and Hesitancy
  • Medicinal Plants and Neuroprotection
  • Insect Pest Control Strategies
  • Public Health and Nutrition
  • Essential Oils and Antimicrobial Activity
  • Pharmaceutical Quality and Counterfeiting
  • Immune responses and vaccinations
  • Ginkgo biloba and Cashew Applications
  • Virology and Viral Diseases
  • Phytochemistry and biological activity of medicinal plants
  • Energy and Environment Impacts

Mekelle University
2019-2020

Diabetes mellitus is a chronic metabolic disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it important to search for alternative therapies. Medicinal plants used in traditional medicines are ideal candidates. Hence, this study was undertaken investigate antidiabetic activity of crude extract solvent fractions from stem bark Terminalia brownii Fresen. (Combretaceae) mice.The vitro α-amylase inhibition assay...

10.2147/jep.s240266 article EN cc-by-nc Journal of Experimental Pharmacology 2020-02-01

Introduction: Medication non-adherence is a major public health problem among diabetes mellitus patients. However, there lack of data regarding its magnitude and the factors contributing to Ethiopia's non-adherence, especially in Tigrai region. This study was conducted assess patients Eastern Zone Tigrai, Northern Ethiopia. Materials Methods: A hospital-based cross-sectional at Adigrat Wukro General Hospitals using pre-tested, self-administered, semi-structured questionnaire developed from...

10.2147/ppa.s278148 article EN cc-by-nc Patient Preference and Adherence 2020-10-01

About 425 million adults had diabetes mellitus globally in 2017. Type 2 accounts for the enormous majority of cases and it is gradually growing which predicted to increase by 48% 2045. Imbalanced cellular carbohydrate lipid metabolism cause an postprandial blood glucose level eventually leads onset progression type mellitus. The lack effective safe hydrolyzing enzyme inhibitors contributes increasing prevalence. Thus, this study was targeted assess α-amylase inhibitory potential isolates...

10.1186/s12906-019-2622-5 article EN cc-by BMC Complementary and Alternative Medicine 2019-08-07

To evaluate the antimalarial effect of aqueous methanolic extract and solvent fractions Meriandra dianthera leaves against Plasmodium berghei in mice model.M. were extracted with 80% methanol dried. The dried crude was then defatted further fractionated chloroform, ethyl acetate, butanol. Acute oral toxicity test performed as per Organization for Economic Cooperation Development guideline 425. Peter's 4-day suppressive used to determine vivo activity fractions.The leaf P < 0.001)...

10.1155/2020/8980212 article EN cc-by Evidence-based Complementary and Alternative Medicine 2020-01-01

The management of pain and inflammation with non-steroidal anti-inflammatory drugs opioid analgesics are currently encountering severe adverse reactions. To overcome these problems, herbal remedies may offer new alternative medicines. Hygrophila schulli is a medicinal plant traditionally used for the treatment inflammation-related disorders; yet, claims not scientifically validated. Hence, this study was aimed to validate traditional use leaves as analgesic remedy.In vitro anti-hyaluronidase...

10.2147/jir.s269717 article EN cc-by-nc Journal of Inflammation Research 2020-09-01

Abstract BackgroundVarious medicinal plants are used as alternative remedies for the management of malaria, an important infectious disease responsible around 228 million cases and 405,000 deaths worldwide in 2018. The worsening is highly associated to emergence drug-resistant parasites. Hence, search new antimalarial agents from traditionally most viable approach. current study was aimed evaluate vitro antiplasmodial property Aloe elegans , monticola Capparis tomentosa, Hygrophila schulli...

10.21203/rs.2.19327/v1 preprint EN cc-by Research Square (Research Square) 2019-12-19
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