A5036213532- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Kruppel-like factors research
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
University of Wrocław
2022-2025
Abstract FGF homologous factors (FHFs) are the least described group of fibroblast growth (FGFs). The FHF subfamily consists four proteins: FGF11, FGF12, FGF13, and FGF14. Until recently, FHFs were thought to be intracellular, non‐signaling molecules, despite sharing structural sequence similarities with other members family that can secreted activate cell signaling by interacting surface receptors. Here, we show lacking a canonical signal peptide for secretion, exported extracellular space....
Abstract Among the FGF proteins, least characterized superfamily is group of fibroblast growth factor homologous factors (FHFs). To date, main role FHFs has been primarily seen in modulation voltage-gated ion channels, but a full picture function inside cell far from complete. In present study, we focused on identifying novel FGF12 binding partners to indicate its intracellular functions. identified significant number were nuclear especially RNA-binding proteins involved translational...
Abstract FGF12 belongs to a subfamily of FGF proteins called homologous factors (FHFs), which until recently were thought be non-signaling intracellular proteins. Our recent studies have shown that although they lack conventional signal peptide for secretion, can reach the extracellular space, especially under stress conditions. Here, we unraveled long “a” isoform is secreted in pathway involving A1 subunit Na(+)/K(+) ATPase (ATP1A1), Tec kinase and lipids such as phosphatidylinositol...
Abstract Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated diverse cellular processes, including transport, autophagy or signaling. Since most the activity galectins depends on their ability to bind sugar chains, exert functions mainly extracellular space at cell surface, which microenvironments highly enriched glycoconjugates. also abundant inside cells, but specific intracellular largely unknown. Here we...