A5086866807- Galectins and Cancer Biology
- Calcium Carbonate Crystallization and Inhibition
- Fibroblast Growth Factor Research
- Marine Biology and Environmental Chemistry
- Microbial Metabolic Engineering and Bioproduction
- RNA and protein synthesis mechanisms
- Toxin Mechanisms and Immunotoxins
- Proteoglycans and glycosaminoglycans research
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Biochemical and Molecular Research
- Marine animal studies overview
- Marine Bivalve and Aquaculture Studies
- Cephalopods and Marine Biology
- Physiological and biochemical adaptations
- Glycosylation and Glycoproteins Research
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Ichthyology and Marine Biology
University of Wrocław
2024
AGH University of Krakow
2019-2023
Wrocław University of Science and Technology
2019-2023
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute plasma-membrane localized signaling hubs that transmit signals from the extracellular environment to cell interior, governing pivotal cellular processes like motility, metabolism, differentiation, division death. FGF/FGFR is critical for human body development homeostasis; dysregulation of units observed in numerous developmental diseases about 10% cancers. Glycosylation a highly abundant posttranslational modification...
Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast factors (FGFs), initiates an intracellular signaling. FGFR1 signaling ensures homeostasis cells by fine-tuning essential cellular processes, like differentiation, division, motility and death. activity coordinated at multiple steps unbalanced contributes to developmental diseases cancers. One the crucial control mechanisms over...
Otoliths are one of the biominerals whose formation is highly controlled by proteins. The first protein discovered to be involved in otolith biomineralization zebrafish was starmaker (Stm). Previously, Stm shown responsible for preferential aragonite, a polymorph calcium carbonate, otoliths. In this work, proteomic analysis adult otoliths performed. only phosphorylated found our studies. Besides previously studied proteins, we several dozens unknown proteins that reveal likely mechanism...
Otoliths and otoconia are calcium carbonate biomineral structures that form in the inner ear of fish humans, respectively. The formation these is tightly linked to an organic matrix framework with otolin-1, a short collagen-like protein from C1q family as one its major constituents.In this study, we examined activity recombinant otolin-1 originating Danio rerio Homo sapiens on bioinspired mineralization slow-diffusion method performed crystals characterization scanning electron microscopy,...
Galectin-8 is a small soluble lectin with two carbohydrate recognition domains (CRDs). N- and C-terminal CRDs of Gal-8 differ in their specificity for glycan ligands. Here, we wanted to find out whether oligomerization individual galectin-8 affects its biological activity. Using green fluorescent protein polygons (GFPp) as an scaffold, generated intrinsically altered valency. We show that oligomers C-CRD are characterized by significant cell surface affinity. Furthermore, the multivalency...
Abstract FGF12 belongs to a subfamily of FGF proteins called homologous factors (FHFs), which until recently were thought be non-signaling intracellular proteins. Our recent studies have shown that although they lack conventional signal peptide for secretion, can reach the extracellular space, especially under stress conditions. Here, we unraveled long “a” isoform is secreted in pathway involving A1 subunit Na(+)/K(+) ATPase (ATP1A1), Tec kinase and lipids such as phosphatidylinositol...
Fish otoliths are calcium carbonate biominerals found in the inner ear commonly used for tracking fish biochronologies and as a model system biomineralization. The process of otolith formation is biologically controlled by numerous biomacromolecules which not only affect crystal size, shape, mechanical properties, but also selection polymorph (e.g., aragonite, vaterite). proteinaceous control over occurs many other species corals, mollusks, echinoderms) exact mechanism protein interactions...
Abstract Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated diverse cellular processes, including transport, autophagy or signaling. Since most the activity galectins depends on their ability to bind sugar chains, exert functions mainly extracellular space at cell surface, which microenvironments highly enriched glycoconjugates. also abundant inside cells, but specific intracellular largely unknown. Here we...