João Luiz Aldinucci Buzzo

ORCID: 0000-0002-2318-5277
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About
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Research Areas
  • Inflammatory mediators and NSAID effects
  • Nanoparticle-Based Drug Delivery
  • RNA Interference and Gene Delivery
  • S100 Proteins and Annexins
  • Pickering emulsions and particle stabilization
  • Protease and Inhibitor Mechanisms
  • Nanoplatforms for cancer theranostics
  • Seaweed-derived Bioactive Compounds
  • Immunotherapy and Immune Responses
  • Polysaccharides Composition and Applications
  • Infectious Diseases and Mycology
  • Cancer Cells and Metastasis
  • Immune cells in cancer
  • Proteins in Food Systems

Universidade Federal do Paraná
2020-2024

Rega Institute for Medical Research
2017

KU Leuven
2017

Gelatinase B or matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) is increased in inflammatory processes and cancer, associated with disease progression. In part, this due to MMP-9-mediated degradation of extracellular matrix, facilitating influx leukocytes into inflamed tissues invasion metastasis cancer cells. MMP-9 produced as proMMP-9 its propeptide subsequently removed by other proteases generate proteolytically active MMP-9. The significance pathologies triggered the development...

10.1371/journal.pone.0174853 article EN cc-by PLoS ONE 2017-04-03
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