A5057014571- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Melanoma and MAPK Pathways
- Toxin Mechanisms and Immunotoxins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Intensive Care Unit Cognitive Disorders
- Cutaneous Melanoma Detection and Management
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Anesthesia and Sedative Agents
- Simulation-Based Education in Healthcare
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Acne and Rosacea Treatments and Effects
- Genetic and rare skin diseases.
- Infectious Diseases and Mycology
- Medicine and Dermatology Studies History
Oxford University Hospitals NHS Trust
2013-2024
Churchill Hospital
2015-2023
University of Oxford
2010-2023
Medical Research Council
2016
MRC Human Immunology Unit
2010-2016
National Institute for Health Research
2016
British Association of Dermatologists
2016
John Radcliffe Hospital
2010-2015
Institute of Molecular Medicine
2010
First-in-class clinical trial of IL-33 blockade shows inhibition neutrophil migration into human skin and modulates atopic dermatitis symptoms.
Objectives We aimed to determine age-specific rates of delirium and associated factors in acute medicine, the impact on mortality re-admission long-term follow-up. Design Observational study. Consecutive patients over two 8-week periods (2010, 2012) were screened for admission, using confusion assessment method (CAM), reviewed daily thereafter. Delirium diagnosis was made Diagnostic Statistical Manual Fourth Edition (DSM IV) criteria. For aged ≥65 years, potentially important covariables...
Objective: To explore associations between bullous pemphigoid (BP) and previous drug use in the United Kingdom.Design: A case-control study comparing history of consecutive patients with BP control subjects.Setting: Tertiary care center for immunobullous diseases skin tumor clinics at Oxford University Hospitals.Patients or Other Participants: Eighty-six 134 controls from same region similar age sex who presented other dermatological diagnoses.Main Outcome Measures: Crude adjusted odds...
Lack of the skin barrier protein filaggrin worsens atopic dermatitis by allergenic activation CD1a-reactive T cells.
Advanced resuscitation skills training is an important and enjoyable part of medical training, but requires small group instruction to ensure active participation all students. Increases in student numbers have made this increasingly difficult achieve.A single-blind randomised controlled trial peer-led vs. expert-led was performed using a sixth-year students as peer instructors. The expert instructors were senior middle grade doctor, nurse who Life Support (ALS) Instructor.A power...
Background Filaggrin null mutations associate with atopic eczema and also asthma when present eczema. However, while epidermal dysfunction is an important factor in disease pathogenesis, it unclear how such interacts immune responses to contribute cutaneous other inflammatory disease. Objectives To gain a better understanding of the mechanisms underlying predisposition order understand different phenotypes possibly identify potential treatment targets. Methods We studied 33 individuals used...
Background. The rate of skin cancer in the UK continues to rise. Aim. To identify current knowledge and awareness attitudes towards avoidance among a variety patient groups aid design future sun‐awareness campaigns. Methods. Patients aged ≥ 16 years presenting one three general practices (two urban, rural) during period 1 June 31 July 2010 were invited complete paper‐based questionnaire collecting data on their sun‐exposure behaviour, with significance assessed by Fisher exact test. Results....
Effective atopic eczema (AE) control not only improves quality of life but may also prevent the march. The Royal College General Practitioners' (RCGP) curriculum does currently provide specific learning outcomes on AE management. We aimed to gain consensus inform development. A modified Delphi method was used with questionnaires distributed gather views a range health care professionals (HCPs) including general practitioners (GPs), dermatologists, dermatology nurses and parents children...
The association of filaggrin mutations with atopic eczema (atopic dermatitis, AD) is well established and it thought that dysfunction impairs the skin’s barrier function allowing allergen penetration subsequent cutaneous sensitisation inflammation. However, as most forms are not associated allergic to common allergens, possibility itself involved in Th1/Th2 polarisation remains. We tested hypothesis delivered skin independently stratum corneum mutations. Wasp stings bypass deliver antigen...
Abstract We present a rare diagnosis in 41-year-old man referred urgently from the infectious diseases team with 3-week history of extensive itchy and painful mucocutaneous blistering ulceration. This initially affected his hands, spreading to involve limbs trunk. His oral genital mucosae were similarly affected. He reported lethargy weight loss secondary reduced intake but was otherwise systemically well. had hypertension managed amlodipine he not recently taken any other medications or...
To identify priorities for future research into the treatment of bullous pemphigoid, mucous membrane pemphigoid and pemphigus vulgaris, we conducted a Priority Setting Partnership (PSP) using James Lind Alliance methodology. The top 10 identified in this PSP represent key questions that patients, carers healthcare professionals have about these diseases which will hopefully address.