A5063148271- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Cell Adhesion Molecules Research
- Ginseng Biological Effects and Applications
- Atherosclerosis and Cardiovascular Diseases
- Lymphatic System and Diseases
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
The University of Queensland
2021-2024
Jiangnan University
2020
Wuxi Fourth People's Hospital
2020
Abstract Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease, however its mechanism has yet be elucidated. The endothelium possesses profound regenerative capacity adapt reorganize that attributed population vessel-resident endovascular progenitors (EVP) governing an endothelial hierarchy. Here, using fate analysis, we show two transcription factors SOX9 RBPJ specifically affect the murine EVP numbers regulate lineage specification. Conditional knock-out...
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (ECFCs). This study aimed to investigate if these are impacted by conditions (i.e., obesity or atherosclerosis) characterized increased serum levels oxidized low-density lipoprotein (oxLDL), a known inducer Endothelial-to-Mesenchymal Transition (EndMT). Our investigation focused understanding effects EndMT self-renewal and associated molecular alterations. In presence...
<title>Abstract</title> Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (ECFCs). This study aimed to investigate if these are impacted by conditions (i.e., obesity or atherosclerosis) characterized increased serum levels oxidized low-density lipoprotein (oxLDL), a known inducer Endothelial-to-Mesenchymal Transition (EndMT). Our investigation focused understanding effects EndMT self-renewal and associated molecular...