A5103228507- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Process Optimization and Integration
- Fault Detection and Control Systems
- Advanced Control Systems Optimization
- Analytical Chemistry and Chromatography
- Heat Transfer and Optimization
- Crystallization and Solubility Studies
- Heat Transfer and Boiling Studies
- Freezing and Crystallization Processes
- Fluid Dynamics and Mixing
- thermodynamics and calorimetric analyses
- Advanced Data Processing Techniques
- Fluid Dynamics and Heat Transfer
- Viral Infectious Diseases and Gene Expression in Insects
- Machine Learning in Materials Science
- Fluid Dynamics and Thin Films
- Reservoir Engineering and Simulation Methods
- Ionic liquids properties and applications
- Particle Dynamics in Fluid Flows
- Research Data Management Practices
- Plasma and Flow Control in Aerodynamics
- Cyclone Separators and Fluid Dynamics
- Aerosol Filtration and Electrostatic Precipitation
- Microfluidic and Bio-sensing Technologies
TU Dortmund University
2012-2023
University of Freiburg
2003-2007
University of Bremen
1994
Improved safety is one of the main drivers for microreactor application in chemical process development and small-scale production.
Abstract Modern research methods produce large amounts of scientifically valuable data. Tools to process and analyze such data have advanced rapidly. Yet, access high‐quality remains limited in many fields, including catalysis research. Implementing the concept FAIR (Findable, Accessible, Interoperable, Reusable) community would improve this situation dramatically. The German NFDI initiative (National Research Data Infrastructure) aims create a unique infrastructure covering all scientific...
Comparing an enhanced simplex algorithm with model-free design of experiments, this work presents a flexible platform for multi-objective, real-time optimisation.
The Internet of Things (IoT), Industry 4.0, and the digitalization business processes offer new opportunities models for process industry, including education training.
Abstract The increased flexibility resulting from the modularization of process plants requires an advanced strategy to supervise distributed control systems (DCSs). connection and coordination multiple equipment assemblies (PEAs) into a modular plant (MP) is called orchestration conducted in so‐called layer (POL). Standardized interfaces enable seamless integration PEAs MP. Current do not yet meet all required features regarding possibility import/export different data structures. Several...
This work presents and evaluates an approach to obtain model kinetic data by combining a microreactor setup real-time reaction monitoring through inline Fourier transform infrared spectroscopy with nonsteady-state conditions self-modeling curve resolution (SMCR). Two reactions, imine synthesis of benzaldehyde benzylamine deprotonation n-butyllithium, serve as proof concept additionally demonstrate the method's broad range application, which includes simple reactions well complex mechanisms....
Heat transfer performance of plate-type metallic microreactors.
The design and calculation of micro mixers is done by conventional analytical numerical calculations. Due to the small dimensions, laminar flow expected mass transfer supposed be dominated diffusion. A detailed CFD-study CFDRC-ACE+ simple static shows a deviation from strictly in wide range Re numbers channel dimensions. under test have T-Profile with rectangular cross sections characteristic dimensions 50 400 μm. mean velocity varied 0,01 m/s 5 m/s, which are typical values for chemical...
The knowledge of product particle size distribution (PSD) in crystallization processes is high interest for the pharmaceutical and fine chemical industries, as well research development. Not only can efficiency crystallization/production quality be increased but also new equipment qualitatively characterized. A large variety analytical methods PSDs available, most which have underlying assumptions corresponding errors affecting measurement volume individual particles. In this work we present...
Based on kinetic investigations in microreactors, a millistructured plate reactor for solvent-free ionic liquid synthesis was designed by combining several scale-up concepts to maintain thermal stability.
Scale-up predictions from a continuous flow micro- (lab) to milliscale (pilot or production) are important but not trivial. To overcome the necessity of time-consuming trials on pilot production scale, this work presents model-based approach that builds prior lab experiments. However, it also improves understanding involved chemical process. A complete process development for highly exothermic organometallic reaction is conducted. Kinetic studies using inline FT-IR measurements, constitute...
Abstract Self-optimisation constitutes a very helpful tool for chemical process development, both in lab and industrial applications. However, research on the application of model-free autonomous optimisation strategies (based experimental investigation) complex reactions high significance, which involve considerable intermediate by-product formation, is still an early stage. This article describes development enhanced microfluidic reactor platform organolithium epoxide that incorporates...
Volatile markets and increasing demands for quality fast availability of specialty chemical products have motivated the rise small-scale, integrated, modular continuous processing plants. As a significant unit operation used product isolation purification, cooling crystallization is part this trend. Here, small-scale integrated quasi-continuous filter belt crystallizer (QCFBC) combines crystallization, solid-liquid separation, drying on single apparatus. This contribution shows general...
Abstract Limited applicability and scarce availability of analytical equipment for micro- millifluidic applications, which are high interest in research development, complicate process control, monitoring. The low-cost sensor presented this work is a modular, fast, non-invasive, multi-purpose, easy to apply solution detecting phase changes concentrations optically absorbing substances single multi-phase capillary flow. It aims at generating deeper insight into existing processes fields...
Abstract Fast chemical process development is inevitably linked to an optimized determination of thermokinetic data reactions. A miniaturized flow calorimeter enables increased sensitivity when examining small amounts reactants in a short time compared traditional batch equipment. Therefore, methodology determine optimal reaction conditions for calorimetric measurement experiments was developed and presented this contribution. Within the methodology, short-cut calculations are supplemented...
Abstract The local gas-liquid mass transfer was characterized during bubble generation in T-contactors and an adjacent micronozzle. A colorimetric technique with the oxygen sensitive dye resazurin investigated to visualize slug flow, deformation, as well laminar turbulent breakup wake of a Two optimized nozzle geometries from previous studies were evaluated concerning volumetric coefficients for low pressure loss, narrow residence time distribution, or high dispersion rates. Highest values k...
Abstract Implementation of data‐based key performance indicators (KPIs) within existing plants usually requires a thorough manual analysis the plant topology to define which sensors could provide reliable information for calculating KPIs. In this publication, we propose an assistance system that automates process. First automatic linkage between structure and operational data is presented evaluation process efficiency. Next, concept prototypical implementation predefined KPIs described. The...
Abstract An automated flow chemistry platform for DNA-encoded library (DEL) technologies requires the integration of a purification process DNA-tagged substrates. It facilitates development further DEL reactions, building block rehearsal, and synthesis. Therefore, recently developed, manual affinity-based batch substrates based on dispersive solid-phase extraction (DSPE) was transferred to using tailored 3D-printed microfluidic devices open-source lab automation equipment. The immobilization...
Abstract Chloromethane is an important reagent for methylations in the process industry. However, as a gas suspected of causing cancer, it rarely used at laboratory scale. Therefore, setup presented here studies under safe and reproducible conditions. The use microreactor guarantees high heat transfer rates low holdup reagent. As proof‐of‐concept, reaction chloromethane with secondary amine morpholine aqueous solution investigated. By applying elevated pressures, liquid‐liquid system...
The characterization of new process equipment often includes tedious experiments, particularly for (cooling) crystallization. This can be cost-intensive and time-consuming when the actual has to continuously operated gain insights. For multi-purpose plants that frequently change substance system, this especially laborious. In order accelerate generation data quasi-continuous filter belt crystallizer (QCFBC), a Peltier-element-driven, simplified experimental benchtop setup is validated in...
Micro-reactors offer distinct advantages over batch reactors currently used within the pharmaceutical and fine chemical industries. Their high surface area-to-volume ratios allow for increased heat mass transfer, which is important controlling reaction selectivity. In addition, micro-reactors are compatible with continuous processing technology, circumventing time delays inherent to systems. Rapid mixing of reactants is, however, limited by difficulty generating turbulence at reduced...
Bubble generation is a very dynamic process including surface forces with fluid flow and structure interaction on short time length scales. This study describes effects during bubble in combination through nozzle for redispersion purpose. At certain velocities phase ratios, liquid jets within gas bubbles have been observed microchannels, which origin from the rear tip of cap penetrate whole bubble. The penetration filament or thread leads to corrugation causes breakup, when opposite hit. In...