A5015754493- Electron Spin Resonance Studies
- Photochemistry and Electron Transfer Studies
- Protein Interaction Studies and Fluorescence Analysis
- Free Radicals and Antioxidants
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Metal complexes synthesis and properties
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Pharmacological Effects of Natural Compounds
Shanxi Medical University
2023
Shaanxi Provincial People's Hospital
2023
GlaxoSmithKline (United States)
2003
South College
2003
New Frontier
1993
The Ohio State University
1982
Purpose: Cefoperazone/sulbactam is a β-lactam/β-lactamase inhibitor combination effective against intra-abdominal, urinary tract, and respiratory infections. Although some studies have suggested that cefoperazone/sulbactam associated with coagulation disorders, it remains debatable whether the of tigecycline or valproic acid increases risk bleeding, as both drugs can lead to disorders. This study aimed explore factors cefoperazone/sulbactam-induced coagulopathy. Patients Methods: was...
Pharmacokinetic evaluation of the potent azepanone-based cathepsin K inhibitor 3 showed that it has an oral bioavailability 42% in rat and 4.8% monkey. The less than optimal bioavailabilities monkey precluded this analogue from being subjected to more detailed pharmacokinetic pharmacodynamic analyses. In vitro vivo studies aimed at identifying mechanisms which may be limiting these species served guide syntheses subsequent analogues for further evaluation. These have led identification...