A5100671629- Antibiotic Resistance in Bacteria
- Pharmacological Effects and Toxicity Studies
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- HIV Research and Treatment
- Prenatal Screening and Diagnostics
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Histone Deacetylase Inhibitors Research
- Cleft Lip and Palate Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Fetal and Pediatric Neurological Disorders
- Cytokine Signaling Pathways and Interactions
- Infant Nutrition and Health
- Actinomycetales infections and treatment
- Pancreatic function and diabetes
- Parasitic Diseases Research and Treatment
- Mosquito-borne diseases and control
- Fungal Infections and Studies
Shaanxi Provincial People's Hospital
2020-2025
Shanxi Provincial Children's Hospital
2025
Chengdu University of Traditional Chinese Medicine
2024
First People's Hospital of Chongqing
2024
Shanxi Medical University
2020-2023
BGI Group (China)
2019
Nanjing Medical University
2010
High-dose (HD) tigecycline is often required for severe multidrug-resistant gram-negative infections in liver failure patients, despite package recommendations to halve the dose those with impairment. This study evaluated efficacy and safety of different doses this population. A retrospective cohort 192 patients Child-Pugh grade C was divided into label-dose (LD), standard-dose (SD), HD groups. Primary secondary outcomes included microbial eradication, mortality, adverse effects. The SD...
Platelet decline is a frequent side effect of valproic acid, medication commonly prescribed to prevent seizures in neurosurgical patients. However, the risk factors for acid-associated platelet remain poorly understood, and it remains unknown whether linezolid or levetiracetam combination with acid associated thrombocytopenia, as both drugs could lead decrease count. This three center, retrospective nested case–control study aimed develop predictive model prediction acid-induced cohort 356...
Purpose: Cefoperazone/sulbactam is a β-lactam/β-lactamase inhibitor combination effective against intra-abdominal, urinary tract, and respiratory infections. Although some studies have suggested that cefoperazone/sulbactam associated with coagulation disorders, it remains debatable whether the of tigecycline or valproic acid increases risk bleeding, as both drugs can lead to disorders. This study aimed explore factors cefoperazone/sulbactam-induced coagulopathy. Patients Methods: was...
Objective This prospective study aimed to establish the valproic acid (VPA) population pharmacokinetic model in Chinese patients and realise personalised medication on basis of pharmacokinetics. Methods The patients’ clinical information VPA plasma concentrations were collected from General Hospital Taiyuan Iron & Steel (Group) Corporation (TISCO). Nonlinear mixed-effect modelling was used build model. To characterise data, a one-compartment with first-order absorption elimination used....
This is the first report describing co-infection of Scedosporium apiospermum and Lichtheimia corymbifera caused by biogas inhalation in two people without underlying medical conditions. Two patients fell into same pig manure pit at time while rescuing another patient (this person died a few hours) inhaled biogas. Both were diagnosed with pulmonary fungal disease developed acute liver failure around Day 52. Their results negative for 1,3-β-d-glucan test weakly positive galactomannan test....
Tigecycline has been widely used for multi-drug resistant bacterial infections in China. Although many studies have reported the risk factors tigecycline-induced hypofibrinogenemia, it remains unknown whether valproic acid or voriconazole combination with tigecycline is related to fibrinogen decline, as both drugs could lead coagulation disorders. The aim of study was develop a nomogram prediction hypofibrinogenemia. This multi-center retrospective case-control study. primary outcomes...
Abstract Backgrounds Tigecycline has a broad spectrum of antimicrobial activity and been approved for the treatment complicated intra-abdominal infections. However, it is debatable whether tigecycline should be used alone or in combination. This study aimed to investigate plus β-lactam antibiotics (combination therapy [CT] group) are superior (monotherapy [MT] non-critically ill infection patients after tumor surgery. Methods was multicenter, retrospective cohort study. The primary outcome...
To investigate the observed variation in glucose tolerance and insulin secretion intrauterine growth retarded newborn rats to explore mechanism of variations, Sprague-Dawley pregnant were allocated into two groups: a control group an energy restricted group. The retardation (IUGR) was induced by 50% calorie restriction from gestational day 15 until term as compared pancreata IUGR dissected respectively. RT-PCR used study mRNA level related synthesis exocytosis. Intraperitoneal tests done...
Background Valproic acid (VPA) has been widely used to prevent epileptic seizures after neurosurgery in China. We have found that the incidence of liver injury (LI) patients using VPA is higher than other patients. Objective The objective this study was investigate risk factors LI neurosurgery. Methods A nested case-control conducted between September 2019 and March 2021. Cases were matched controls by age body mass index (BMI). Conditional logistic regression estimate odds ratios...
The advent of biologics has brought renewed hope for patients with severe asthma, a condition notorious being hampered by poor response to conventional therapies and adverse drug reactions owing corticosteroid dependence. However, are administered as injections, thereby precluding the benefits inhalation therapy could offer such increased bioavailability at site action, minimal systemic side effects, non-invasiveness, self-administration. Here, 2-hydroxypropyl-beta-cyclodextrin ʟ-leucine...
Abstract: We report a case of co-infection with Nocardia farcinica, Pneumocystis jirovecii , and Aspergillus fumigatus due to tooth extraction in mildly immunosuppressed patient. This patient did not respond well meropenem-based regimen, the number lesions was significantly reduced after switching imipenem. The patient's trough concentration insufficient when using conventional doses voriconazole for treatment pulmonary aspergillosis. After adding omeprazole, reached standard levels symptoms...
Lupus nephritis (LN) is an autoimmune disease that rapidly progresses as a secondary consequence of systemic lupus erythematosus (SLE) and has very poor prognosis. Therefore, this study aimed to identify characteristics immune cell infiltration investigate potential therapeutic targets using bioinformatics methods the Murphy Roths Large/lymphoproliferation (MRL/lpr) mouse model. In study, total 2,810 differentially expressed genes (DEGs) were identified, which primarily enriched in...
To study the imaging features of fetuses with cleft lip and explore genetic basis these fetuses. A cohort 142 (including palate), which were detected by prenatal ultrasound confirmed specialist consultants, collected. MRI scanning performed in a proportion The available tissues, including fetal umbilical cord from live-born or thigh muscle aborted fetuses, subject to low depth whole-genome sequencing (WGS), identify chromosomal anomalies microduplication/deletions (CNV). Of there are 94 male...
This study aimed to investigate the relationship between gene polymorphisms and clinical factors with concentrations of valproic acid (VPA) in adult patients who underwent neurosurgery China.A total 531 serum concentration samples at steady state were collected from 313 develop a population pharmacokinetic (PPK) model. Data analysis was performed using nonlinear mixed effects modeling. Covariates included demographic parameters, biological characteristics, genetic polymorphism. Bootstrap...