A5102937460- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Plant Molecular Biology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heat shock proteins research
- Neuropeptides and Animal Physiology
- Hippo pathway signaling and YAP/TAZ
- Pharmacological Effects and Toxicity Studies
- Plant Surface Properties and Treatments
- Proteoglycans and glycosaminoglycans research
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Stress, Anesthesia, and Immune Response
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
Ewha Womans University
2019-2022
P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed clinical trials due low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have examined surmount this limitation. We breast protein (BCRP) vitro vivo by P-gp inhibitors derived from compounds previous studies. increased the accumulation anticancer drug, topotecan (TPT)—a substrate BCRP, albeit with higher affinity for BCRP—in...
Although shed syndecan-2 potentiated the tumorigenic activities of colon cancer cells, how increases this potential remains unclear. Using an orthotopic mouse model cancer, we show that progression by cooperatively promoting angiogenesis. Co-administration with a synthetic peptide (S2LQ) enhanced survival and tumor engraftment luciferase-expressing CT26 adenocarcinoma cells orthotopically implanted into cecum BALB/c mice. Intravenous injection S2LQ further growth tumors in cecum, tissue...
A series of fexaramine analogs were synthesized and evaluated to develop an intestine-selective/specific FXR partial agonist. Introduction both a CN substituent at the C-2 in biphenyl ring fluorine C-5 aniline markedly increased agonistic activity. 27c showed 53 ± 3% maximum efficacy relative GW4064 agonist assay. substantial amount was absorbed intestine after oral administration rats, then it rapidly metabolized inactive carboxylic acid 44 by serum esterases. In CDAHFD-fed mice, strongly...
Heat shock protein beta-1 (HSPB1) is a multifaceted that controls cellular stress, modulates cell differentiation and development, inhibits apoptosis of cancer cells. Increased HSPB1 expression highly associated with poor outcomes in lung by enhancing migration invasion; therefore, targeting may be promising therapeutic for fibrosis. Although the inhibitor J2 has been reported to exhibit potent antifibrotic effects, it remains unclear whether how directly inflammatory immune responses...
Paclitaxel (PTX) is an anticancer agent that used to treat many cancers but it has a very low oral bioavailability due, at least in part, the drug efflux transporter, P-glycoprotein (P-gp). Therefore, this study was performed enhance of PTX. In study, we investigated effects several piperazine derivatives on P-gp function vitro. Compound 4 selected as most potent inhibitor from vitro results for examining pharmacokinetic (PK) changes PTX rats. increased AUCinf without alterations Cmax value....
Dimeric translationally controlled tumor protein (dTCTP), also known as histamine-releasing factor, amplifies allergic responses and its production has been shown to increase in inflammatory diseases such asthma. Despite the critical role of dTCTP inflammation, little is about pathways, associated cellular networks, underlying molecular mechanisms. In this study, we explored dTCTP-mediated networks mechanisms with lipopolysaccharides (LPS)-induced severe LPS stimulation increased by mast...