Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular mechanisms of how ginseng exerts its effects. Recently, we isolated a novel lysophosphatidic ac

Photocatalytic water splitting is the most environmentally friendly method to generate energy. Despite intense research in this area, rapid charge-carrier recombination and limited light absorption of semiconductor-based photocatalysts remain key challenges. Herein, protonated g-C3N4/Ti3C2Tx MXene hollow spheres, fabricated by electrostatic layer-by layer assembly a sacrificial template, were used for effective photocatalytic hydrogen (H2) evolution. The constructed three-dimensional (3D)...

Recently, we isolated a subset of glycolipoproteins from Panax ginseng, that designated gintonin, and demonstrated it induced [Ca2+]i transients in cells via G protein-coupled receptor (GPCR) signaling pathway(s). However, active components responsible for Ca2+ mobilization the corresponding receptor(s) were unknown. Active component(s) gintonin analyzed by liquid chromatography-electrospray ionization-tandem mass spectrometry ion-mobility spectrometry, respectively. The receptor(s)were...

Robotic training of children with crouch gait improved posture and walking by enhancing muscle strength coordination.

Gait and balance disorders are major problems that contribute to falls among subjects with Parkinson's disease (PD). Strengthening the compensatory responses through use of perturbations may improve in PD. To date, it is unclear how PD affects ability react adapt delivered while walking. This study aims investigate walk, respond perturbations, produce acute short-term effects reactions gait stability. A cable-driven robot was used train nine patients age-matched controls multidirectional...

Highly dispersive molybdenum disulfide nanoflakes (MoS2 NFs), without any phase transition during the exfoliation process, are desirable for full utilization of their semiconductor properties in practical applications. Here, we demonstrate an innovate approach fabricating MoS2 NFs by using hydrazine-assisted ball milling via synergetic effect chemical intercalation and mechanical exfoliation. The obtained have a lateral size 600-800 nm, thickness less than 3 high crystallinity 2H...

Lysosome-targeting chimeras (LYTACs) harness the cell's lysosomal degradation machinery to break down extracellular and membrane proteins. Previous methods used a synthetic glycopeptide containing multiple serine-O-mannose-6-phosphate (poly-M6Pn), which presented challenges such as complexity potential immunogenicity associated with poly-M6Pn. This study introduced LYTAC formulation, LYTACgyM6pG, uses glyco-engineered yeast-derived mannose-6-phosphate glycans (gyM6pGs) for transport,...

Seated postural abilities are critical to functional independence and participation in children with cerebral palsy, Gross Motor Functional Classification System (GMFCS) levels III-IV. In this proof-of-concept study, we investigated the feasibility of a motor learning-based seated training robotic Trunk-Support-Trainer (TruST) longitudinal single-subject-design (13y, GMFCS IV), its potential effectiveness group 3 (6-14y, III-IV). TruST is motorized-cable driven belt placed on child's trunk...

The objective of this paper is to investigate the effect thickness and moisture on temperature distributions reinforced concrete walls under fire conditions. Toward goal, first three wall specimens having different thicknesses are heated for 2 h according ISO standard heating curve distribution through measured. Since thermal behavior tested influenced by thickness, as well content, additional prepared preheated reduce content then exposure. experimental results clearly show temperatures...

Sensory feedback from body-powered and myoelectric prostheses are limited, but in different ways. Currently, there no empirical studies on how incidental differs between prostheses, or these differences impact grasping. Thus, the purpose of this study was to quantify grasping performance prosthesis users when presented with forms feedback. Nine adults upper limb loss nine without (acting as controls) completed two tasks a virtual environment. In first task, participants used visual,...

Dynamic seated trunk control is required during the execution of many everyday tasks. These tasks require an intricate coordination between head, upper and lower trunk, pelvis. Furthermore, reaching beyond arm's length requires precise joint intersegmental coordination. With practice specificity, humans can learn particular motor skills that may be performed across contexts similar characteristics. As new are explored, human movements learned organized by release constraint...

P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed clinical trials due low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have examined surmount this limitation. We breast protein (BCRP) vitro vivo by P-gp inhibitors derived from compounds previous studies. increased the accumulation anticancer drug, topotecan (TPT)—a substrate BCRP, albeit with higher affinity for BCRP—in...

Data-driven drug discovery exploits a comprehensive set of big data to provide an efficient path for the development new drugs. Currently, publicly available bioassay sets extensive information regarding bioactivity profiles millions compounds. Using these large-scale screening sets, we developed novel in silico method virtually screen hit compounds against protein targets, named BEAR (Bioactive compound Enrichment by Assay Repositioning). The underlying idea is reuse predicting targets...

Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, life-prolonging effects. However, the cellular mechanisms by resveratrol acts are relatively unknown, especially terms of possible regulation receptors involved synaptic transmission. 5-Hydroxytryptamine type 3A (5-HT3A) receptor one several ligand-gated ion channels fast In present study, we investigated effect on mouse 5-HT3A channel...

Gait and balance disorders are among the most common causes of falls in older adults. Most occur as a result unexpected hazards while walking. In order to improve effectiveness current fall-prevention programs, new training paradigms aim strengthen control compensatory responses required after external perturbations. The this study was analyze adaptions reactive proactive strategies stability repeated exposures waist-pull perturbations delivered Eight healthy young subjects participated...

Quercetin mainly exists in the skin of colored fruits and vegetables as one flavonoids. Recent studies show that quercetin, like other flavonoids, has diverse pharmacological actions. However, relatively little is known about quercetin effects regulations ligand-gated ion channels. In previous reports, we have shown regulates subsets homomeric channels such glycine, 5-HT3A α7 nicotinic acetylcholine receptors. present study, examined on heteromeric neuronal α3β4 receptor channel activity...

Pelvic movement is important to human locomotion as the center of mass located near pelvis. Lateral pelvic motion plays a crucial role shift on stance leg, while swinging other leg and keeping body balanced. In addition, vertical helps reduce metabolic energy expenditure by exchanging potential kinetic during gait cycle. However, patient groups with cerebral palsy or stroke have excessive that leads high expenditure. they higher chances falls ofmass could deviate outside base support. this...