A5068317168- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Dementia and Cognitive Impairment Research
- Genetic Neurodegenerative Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Glycogen Storage Diseases and Myoclonus
- Genetics, Aging, and Longevity in Model Organisms
- Amyotrophic Lateral Sclerosis Research
- Acute Ischemic Stroke Management
- Parathyroid Disorders and Treatments
- COVID-19 epidemiological studies
- Food Security and Health in Diverse Populations
- Insurance, Mortality, Demography, Risk Management
- Neurological diseases and metabolism
- Ginkgo biloba and Cashew Applications
- Cerebrovascular and Carotid Artery Diseases
- Prion Diseases and Protein Misfolding
- Statistical Methods and Bayesian Inference
- Global Public Health Policies and Epidemiology
- Coenzyme Q10 studies and effects
- Restless Legs Syndrome Research
- Retinal Development and Disorders
- Genomics and Rare Diseases
Universidade do Estado do Rio de Janeiro
2022-2023
Columbia University
2001-2011
University of Michigan
2010
Mount Sinai Medical Center
2010
Colorado Neurological Institute
2010
Long Island Jewish Medical Center
2010
University of Virginia
2010
University of California, San Diego
2010
Indiana University – Purdue University Indianapolis
2007
Indiana University School of Medicine
2007
<b><i>Objective: </i></b> To determine whether leisure activities modify the risk for incident dementia. <b><i>Background: Although high educational and occupational attainments have been associated with reduced of dementia, relation between dementia has not adequately investigated. <b><i>Methods: A total 1,772 nondemented individuals aged 65 years or older, living in northern Manhattan, New York, were identified followed longitudinally a community-based cohort incidence study. Subjects’ at...
OBJECTIVES: To characterise risk factors for the acquisition of genital warts and specifically to determine whether condoms confer protection from infection. METHODS: A retrospective case-control study comparing demographic, behavioural, sexual in men women with without newly diagnosed warts, who attended Sydney Sexual Health Centre (SSHC), an inner city public health centre, 1996. Data were extracted SSHC database. Crude odds ratios (OR) calculated compare cases controls significant then...
Background and Purpose— Intravenous alteplase (rtPA) remains the only approved treatment for acute ischemic stroke, but its use limited. In a previous pilot dose-escalation study, intravenous tenecteplase showed promise as potentially safer alternative. Therefore, Phase IIB clinical trial was begun to (1) choose best dose of carry forward; (2) provide evidence either or futility further testing versus rtPA. If established, then would continue III efficacy comparing selected standard Methods—...
To evaluate the association of incident dementia with mortality in a cohort patients idiopathic PD who were nondemented at baseline evaluation, controlling for extrapyramidal sign (EPS) severity each study visit.The development has been associated reduced survival PD. Because EPS is both and PD, may be confounded by disease severity.A was followed annually neurologic neuropsychological evaluations. The total Unified Rating Scale (UPDRS) motor score examined using Cox proportional hazards...
Abstract We analyzed the association of neuropsychological test impairment at baseline with development dementia in idiopathic Parkinson's disease (PD) patients. A cohort nondemented PD patients from northern Manhattan, NY was followed annually neurological and evaluations. The battery included tests verbal nonverbal memory, orientation, visuospatial ability, language, abstract reasoning. scores incident using Cox proportional hazards models. analysis controlled for age, gender, education,...
Abstract Objective Amyotrophic lateral sclerosis (ALS) is a devastating, and currently incurable, neuromuscular disease in which oxidative stress mitochondrial impairment are contributing to neuronal loss. Coenzyme Q10 (CoQ10), an antioxidant cofactor, has shown promise ALS transgenic mice, clinical trials for neurodegenerative diseases other than ALS. Our aims were choose between two high doses of CoQ10 ALS, determine if it merits testing Phase III trial. Methods We designed implemented...
We report the first case of 10-year disease-free survival in a patient with small cell lung cancer (SCLC) brain metastasis. A 63-year-old man was found to have SCLC metastasis and underwent chemoradiotherapy. Radiation therapy delivered brain, lungs, mediastinum supraclavicular fossa. Chemotherapy regimen mainly consisted etoposide-plus-cisplatin. The has remained alive for more than 10 years after diagnosis no relapses.
Abstract Age and severity of extrapyramidal signs have been consistently associated with incident dementia in Parkinson's disease. We evaluated the separate combined effects age on risk disease setting a population‐based prospective cohort study. total Unified Disease Rating Scale motor score at baseline evaluation were dichotomized median. Four groups patients defined: younger age/low (reference), age/high severity, older severity. Risk ratios for calculated Cox proportional hazards models...
<h3>Background</h3> Action tremor is often noted in patients with Parkinson disease (PD), yet the clinical correlates of this type have been focus few studies. It not clear whether action a manifestation underlying basal ganglia disease. <h3>Objective</h3> To determine severity PD associated age, age at onset, duration, levodopa dose, rest tremor, or other motor (ie, bradykinesia, rigidity) and nonmotor manifestations PD. <h3>Methods</h3> Patients (N = 197) were ascertained as part familial...
Abstract The role of heredity in early‐ versus late‐onset Parkinson's disease (PD) is controversial. We estimated the degree increased risk PD first‐degree relatives 221 probands with age onset 50 years or younger and 266 older than compared 409 control probands. Risk was similar among early‐onset (risk ratio [RR], 2.9; 95% confidence interval [CI], 1.6–5.0; p = 0.0002) (RR, 2.7; CI, 1.6–4.4; when each controls. However, siblings were at markedly controls 7.9; 2.5–25.5; 0.0005), whereas...
<b>Background: </b> The combination of a small pool patients at any given time with the availability many potential neuroprotective agents to be tested in ALS requires efficient phase II trial designs. <b>Objective: To describe design Clinical Trial High Dose Coenzyme Q10 (CoQ10) (QALS study)—a II, randomized, placebo-controlled, double-blind, multicenter clinical trial. <b>Methods: study features two stages. first stage (dose selection) identifies which doses CoQ10 (1800 mg or 2700 mg) is...
Background: Evidence does not support the view that Parkinson disease (PD) represents an accelerated aging process; however, additional contribution of to severity different motor signs in patients with PD is known.This knowledge may have implications for clinical trials neuroprotective agents PD.Objective: To investigate idiopathic PD.Setting: Center Disease and Other Movement Disorders Columbia University Medical a neurology clinic primarily served individuals from Washington...
To determine (i) the prevalence and characteristics of harmful alcohol consumption in general practice attendees; (ii) social psychological associations with drinking (iii) recognition by GPs.A cross-sectional study ten practices Goa, India. A total 1567 attendees were recruited.A 338 men (41%) 597 women (81%) reported that they never consumed alcohol. One hundred twenty-eight people or 8.2% scored >or=8 on AUDIT [123 (15%) five (0.7%) women] classified as dependent drinkers. The population...
We evaluated the reliability and sensitivity to change over time of a newly developed self-administered version ALS functional rating scale-revised (ALSFRS-R) in 60 consecutive patients from an clinic. The ALSFRS-R showed excellent (intraclass correlation = 0.93, 95% CI: 088 0.96) similar vs standard evaluator-administered ALSFRS-R.
Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy data obtained in this way is unclear.To assess interinformant reliability and validity information first-degree relatives cases controls.A structured FHI was administered to nondemented controls a second informant (self-report, sibling or child subject) for each relative. Interinformant agreement assessed four algorithm-derived diagnostic categories PD: definite, definite probable, probable possible...
<b><i>Background:</i></b> Action tremor may be more prevalent in relatives of patients with Parkinson's disease (PD) than control subjects. This could represent mild PD or essential tremor. An estimate the risk this condition families is important when studying genetics PD. <b><i>Objectives:</i></b> To determine action first-degree probands tremor-dominant (TD-PD) and postural instability gait disorder (PIGD-PD) compared probands. <b><i>Methods:</i></b> participated a familial aggregation...
Abstract The extent to which concomitant Alzheimer's disease (AD) is etiologically related the development of dementia in Parkinson's (PD) remains controversial. We explored association four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, incident PD. A cohort 180 nondemented PD patients from Washington Heights community northern Manhattan, New York, completed a factor questionnaire at baseline was followed annually neurological...
Abstract Field work is commonly required in movement disorders research. Sending neurologists into the field can be logistically challenging and costly. Alternatively, neurological examinations may videotaped reviewed later. There little knowledge of validity examination diagnosis Parkinson's disease (PD). We examined Unified Disease Rating Scale (UPDRS) motor PD, sought to determine which factors are associated with incorrect diagnoses. PD patients controls were enrolled a familial...
Objective: To investigate the risk of Alzheimer disease (AD) in first-degree relatives patients with Parkinson (PD) compared controls.Design: Case-control study, family history method, and reconstructed cohort approach.Methods: Probands PD without dementia control probands, matched by age strata, sex, ethnicity, were examined person enrolled knowledge other neurological disorders.Disease status probands was ascertained through a structured interview administered to proband second informant...
TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated slow enrollment before regulatory approval use II patients in III.(1) To review the design and comprehensive type I error rate simulations (2) to discuss issues raised during review, facilitate future similar designs.In II, early (24-h) outcome adaptive sequential procedure selected one three doses III comparison with rt-PA. Decision rules comparing this dose...
<h3>Background</h3> The pathogenesis of essential tremor (ET) is unknown, but it could be neurodegenerative. Weight loss has been observed in patients with neurodegenerative diseases. <h3>Objectives</h3> To compare body mass index (BMI) (calculated as weight kilograms divided by the square height meters) ET cases and controls to determine whether BMI correlated severity duration. <h3>Methods</h3> Patients were ascertained from Neurological Institute New York, NY. Control subjects recruited 2...
Aging-related diseases are the most prevalent in advanced countries nowadays, accounting for a substantial proportion of mortality. We describe explanatory properties an evolution-based model causation (EBMC) applicable to aging-related and intrinsic The EBMC takes sufficient component causes as starting point develops it using evolutionary statistical theories. Genetic classified "early-onset" or "late-onset" environmental "evolutionarily conserved" recent." considered occur random events...