A5062205579- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Genetic and Kidney Cyst Diseases
- Pediatric health and respiratory diseases
- Fetal and Pediatric Neurological Disorders
- Advanced Glycation End Products research
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Hedgehog Signaling Pathway Studies
- Celiac Disease Research and Management
- Adipose Tissue and Metabolism
- Renal Diseases and Glomerulopathies
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Infant Health and Development
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Birth, Development, and Health
University of Messina
2014-2023
Istituto Ortopedico Gaetano Pini
2018-2023
Pediatrics and Genetics
2017
Policlinico Universitario di Catania
2006-2008
University Hospital of Heraklion
2008
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008
University of Crete
2008
To date cytokines profile in AEDS is poorly described children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels atopic eczema/dermatitis syndrome (AEDS) children healthy controls, (aAEDS) nonatopic (naAEDS) subtypes their relationship with disease severity. A total of 181 aAEDS 93 were evaluated. According to skin-prick test (SPT) for allergens serum IgE, all patients subdivided two groups: 104 77 naAEDS. In patients, IL-17, detected. Serum IL-17 IL-23 significantly higher,...
BACKGROUND Genetic factors have an important role in atopic dermatitis (AD) predisposition. Toll like receptor (TLR) are mediators between environment and immune system. There incosnsitent studies about TLSR polymorphisms AD. OBJECTIVE This study examined whether single nucleotide polimorphisms (SNPs) the genes for TLR2 TLR4 could be associated with AD phenotypes its clinical severity a large group of Italian children. METHODS 187 children Ad 150 healthy were recruited. was assessed by...
The nuclear protein high mobility group box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of mediators, and it has recently emerged as key player in different acute chronic immune disorders. Several lines evidence demonstrate HMGB1 actively released extracellularly from cells or passively necrotic cells. Because ability sustain inflammation, we investigated whether present nasal fluids patients with forms rhinitis.HMGB1 levels were evaluated healthy subjects...
nificant difference was found between UC patients and control group (P > 0.05).In CD patients, no significant association with G908R variant found.L1007finsC SNP showed an (9.8%) compared controls (2.9%, P = 0.002) (2.3%, 0.01).Moreover, in L1007finsC mutations were significantly associated different phenotypes to wild-type patients.No of IBD the TLR4 SNPs either cohort (allele frequencies: D299G-controls 3.9%, 3.7%, 3.4%, 0.05; T399I-controls 2.9%, 3.0%, 0.05). CONCLUSION:These findings...
Allergic rhinitis (AR) is characterized by an inflammatory reaction. High-mobility group box-1 protein (HMGB1) has many characteristics similar to classic proinflammatory cytokines. No study yet investigated its role in AR. The aim of this was measure HMGB1 levels the fluid recovered from nasal lavage children with untreated AR and control subjects.The conducted on 104 subjects (48 males 56 females, median age 10.3 ± 3.4 years) 97 healthy (42 55 females) who were age-matched (median 9.8 4.1...
Summary High mobility group box ‐1 ( HMGB 1) represents a common causal agent for various types of diseases, including infective pathologies. This study aimed to investigate the role 1 in β‐thalassemia major TM ) by evaluating its diagnostic and prognostic role. Fifty‐one patients 30 healthy subjects HS were enrolled. Receiver operating characteristics ROC analysis was employed calculate area under curve AUC determine best cut‐off values capable identifying infectious episodes. Adjusted risk...
<b><i>Background:</i></b> Recently, Th17 cells have been found to participate in the pathogenesis of allergic asthma. IL-23 is a cytokine that may be implicated modulating response. This study aimed at evaluating and relating it lung function asthmatic children. <b><i>Methods:</i></b> Seventy-eight children 40 healthy were evaluated. Spirometry serum measurement (ELISA kit) performed all <b><i>Results:</i></b> levels...
Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children. From nasopharyngeal or conjunctival mucosa of infected individuals, RSV spreads to lower tract causing acute bronchiolitis pneumonia after an incubation period 4-6 days. In addition its well-documented tropism for airway epithelium, it has been shown previously that can also spread hematogenously efficiently infect extrapulmonary tissues human hosts. Furthermore, animal models...
Abstract Recurrent respiratory infections ( RRI s) are frequent in children and characterized by more than 6 airway 1 year or upper infection per month the period between September April 3 lower year. Often pediatric s related to predisposing factors, such as reduced size, poor tussive reflex, immaturity of immune system. due immature system a transient condition, with spontaneous resolution school age. However, some expression complex diseases. Red flags onset symptoms first life,...
High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma.The aim this study was to investigate the role HMGB1 as guidance for treatment management children asthma.Thirty asthma 44 healthy were enrolled. The classified according Global Initiative Asthma Guideline disease severity criteria. Sputum levels lung function index (percentage forced expiratory volume second [FEV1%]) recorded cohort at baseline (T0) after 3 (T3) 6 (T6) months...