A5019608179- Dermatological diseases and infestations
- Pharmacy and Medical Practices
- Pharmaceutical Practices and Patient Outcomes
- Cancer Treatment and Pharmacology
- Cultural Competency in Health Care
- Advanced Breast Cancer Therapies
- Pathogenesis and Treatment of Hiccups
- Genetics and Neurodevelopmental Disorders
- Nausea and vomiting management
- Insects and Parasite Interactions
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Pharmaceutical studies and practices
- Chromatin Remodeling and Cancer
- Atrial Fibrillation Management and Outcomes
- Cancer-related cognitive impairment studies
- Chemotherapy-induced organ toxicity mitigation
- Health Systems, Economic Evaluations, Quality of Life
- Allergic Rhinitis and Sensitization
- Venous Thromboembolism Diagnosis and Management
Juntendo University
2022-2024
Tokyo University of Science
2019-2021
St. Luke's International Hospital
2020
Autism spectrum disorders (ASD) are associated with mutations of chromodomain-helicase DNA-binding protein 8 (Chd8) and tuberous sclerosis complex 2 (Tsc2). Although these ASD-related genes detected in glial cells such as microglia, the effect Chd8 or Tsc2 deficiency on microglial functions microglia-mediated brain development remains unclear. In this study, we investigated role cytokine expression, phagocytosis activity, neuro/gliogenesis from neural stem (NSCs) vitro. knockdown microglia...
Abstract In Japan, pyrethroid‐resistant head lice have been increasing; however, only 0.4% phenothrin, a pyrethroid drug, is available as an over the counter formulation. recent years, Sumithrin ® Lotion containing 5% phenothrin (PHT) was approved for scabies. USA, Sklice 0.5% ivermectin (IVM) used treatment of lice. Therefore, to enhance in we conducted clinical study confirm efficacy and safety combination regimen PHT IVM (PI regimen). Twelve cases were enrolled applied all patients on day...
Abstract Background: Treatment-related toxicities (TRT) may decrease patient’s quality of life (QOL) and result in a adherence to the therapy. Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is), such as palbociclib (PAL) abemaciclib (ABM) improved patients’ outcomes with estrogen receptor-positive (ER+) HER2 negative (HER2-) advanced breast cancer (ABC), however, majority patients who undergo CDK4/6i therapy experience ≥ Grade 2 TRTs, hematological abnormalities, gastrointestinal disorders or...
As a novel method of ivermectin (IVM) administration for the treatment scabies, we devised whole-body bathing (WBB), in which patients are immersed fluid that contains IVM. A multi-institutional trial elderly with scabies was conducted to investigate efficacy and safety IVM-WBB. Seven were enrolled received IVM-WBB up four times at 1-week interval. The cure defined as absence mites two consecutive microscopic or dermoscopic examinations weekly intervals new skin lesions indicative scabies....
STROMECTOL® Tablets (ivermectin), an oral scabicide, is often administered to patients as a simple suspension via feeding tube. However, other studies have reported that this method reduces the dose of ivermectin by 10-50％ compared associated with administration. There are several devices used for administration This study proposes appropriate such First, we recovery ratio different 6 (a syringe, dispenser, small cup, kendakun, bottle and quick bag). Among them, results showed bottle, bag...
Abstract Objectives The combination therapy of phenothrin (PHT) and ivermectin (PI regimen) was effective for pyrethroid‐resistant head lice in Okinawa; however, further investigations have been required to improve the regimen. This study aimed investigate efficacy modified PI (mPI) regimen, which increased maximum number PHT treatments regimen by one, Tsukuba, has a low mutation rate compared Okinawa. Methods An open‐label, uncontrolled, exploratory conducted at Department Dermatology,...
Objective: According to the current treatment guideline for breast cancer issued by Japanese Breast Cancer Society, surgery or stereotactic radiotherapy is recommended patients with solitary brain metastasis (BM), while whole (WBRT) multiple BMs. Common treatment-related toxicities during include fatigue, drowsiness, alopecia, headache, nausea, vomiting, however, elevation of blood pressure has not been reported. We report a case headache due high WBRT. Case: A 5X-year female was diagnosed...
Introduction Triple antiemetic therapy with neurokinin-1 receptor antagonist, 5-hydroxytryptamine type 3 and dexamethasone has been widely recommended for high emetogenic chemotherapeutic (HEC) agents regimens, including anthracycline combined cyclophosphamide (AC). The addition of olanzapine (OLZ) 5 mg or 10 to the triple demonstrated superiority in efficacy compared standard triplet a cisplatin-based HEC regimen. Although OLZ plus treatment may also be effective patients on an AC-based...