A5100434953- Autophagy in Disease and Therapy
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Quinazolinone synthesis and applications
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Colorectal Cancer Screening and Detection
- Ginseng Biological Effects and Applications
- Calpain Protease Function and Regulation
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Marine Sponges and Natural Products
- Obesity, Physical Activity, Diet
- Pharmacy and Medical Practices
- Phytochemistry and biological activity of medicinal plants
- Bone and Dental Protein Studies
- Bioactive Compounds and Antitumor Agents
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Aquaculture Nutrition and Growth
Kyung Hee University
2005-2024
Asan Medical Center
2019
University of Ulsan
2019
Ulsan College
2019
Seoul National University Bundang Hospital
2018
Korea Research Institute of Bioscience and Biotechnology
2014
Pukyong National University
2008-2013
Korea University
2008
Abstract Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found Cannabis sativa , endowed with many pharmacological activities. We investigated cytotoxic effect CBD panel colorectal cancer (CRC) cells (HT‐29, SW480, HCT‐116, HCT‐15). induced significant cytotoxicity as evidenced results MTT assay, live‐dead flow cytometric analysis. Since displayed...
Abstract Background Endocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge that poses several unmet needs the management of disease. This study aimed to investigate prognostic value c-MET-positive circulating tumor cells (cMET+ CTCs), ESR1 / PIK3CA mutations, and cell-free DNA (cfDNA) concentrations patients with receptor-positive (HR+) metastatic (mBC). Methods Ninety-seven HR+ mBC were prospectively...
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a JNK-targeting compound has been developed that may be of utility in HER2-positive mammary carcinoma. The design pyrimidine-and coumarin-linked structure targeting JNK was explored the lead PC-12 [4-(3-((2-((4-chlorobenzyl)thio) pyrimidin-4-yl)oxy)propoxy)-6-fluoro-2H-chromen-2-one (5d)] observed to selectively inhibit proliferation BC cells....
EGFR and Wnt/β-catenin signaling pathways play a prominent role in tumor progression various human cancers including non-small-cell lung carcinoma (NSCLC). Transactivation crosstalk between the may contribute to aggressiveness of cancers. Targeting these oncogenic with small molecules is an attractive approach counteract types In this study, we demonstrate effect euphorbiasteroid (EPBS) on NSCLC cells. EPBS induced preferential cytotoxicity toward A549 (wildtype EGFR-expressing) cells over...
Hepatocellular carcinoma (HCC) is a fatal cancer that often diagnosed at the advanced stages which limits available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) results in activation subsequently triggers PI3K/Akt/mTOR axis. Overexpression HCC tissues has been demonstrated to contribute tumor progression and metastasis.
Euphorbiasteroid (EPBS) has gained attention for its activity against human lung cancer and sarcoma; however, impact on hepatocellular carcinoma not yet been elucidated. Here, we investigated the cytotoxic effect of EPBS (HCC) cells. We found that induced both apoptosis autophagy in HCC Additionally, observed treatment suppressed constitutive as well inducible activation a signal transducer activator transcription 3 (STAT3) protein expression. Moreover, promoted expression SHP-1 production...
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a-hexahydrocyclopenta[e] [1,2]oxazine (FPPO; BSO-07) on JNK-driven demonstrated human breast (BC) MDA-MB231 MCF-7 cells respectively. BSO-07 imparted significant cytotoxicity BC cells, induced JNK, increased intracellular reactive oxygen species...
Using reliable measurement tools is becoming increasingly important as the prevalence of obesity among children increases in Korea. The Dutch Eating Behavior Questionnaire for Children (DEBQ-C) measures three eating behaviors associated with overeating. This study aims to validate DEBQ-C use Korean and adolescents high body weight. It examines psychometric features translation investigates relationship between subscale scores weight status participants (categorized into overweight, obese,...
Radiotherapy is an important treatment for many malignant tumors, but there are recent reports that radiation may increase the malignancy of cancer cells by stimulating expression type IV collagenases. In this study, we examined changes in matrix metalloproteinase (MMP) inhibitors, such as tissue inhibitors (TIMP)-1, TIMP-2 and RECK, response to irradiation Panc-1 pancreatic cells. Irradiation increased RECK protein levels not mRNA levels, whereas no significant were found TIMP-1 TIMP-2. The...
Background/Aims Sessile serrated adenomas (SSAs) are known to be precursors of colorectal cancer (CRC). The proper interval follow-up colonoscopy for SSAs is still being debated. We sought determine the surveillance in patients diagnosed with South Korea. Methods retrospectively reviewed medical records who received 1 or more colonoscopies. information included patient baseline characteristics, SSA and information. Results From January 2007 December 2011, 152 8 synchronous adenocarcinomas...
Purpose We evaluate the prognostic value of primary tumor location for oncologic outcomes in patients with colon cancer (CC). Methods CC treated curative surgery between 2009 and 2012 were classified into 2 groups: right-sided (RCC) left-sided (LCC). Recurrence-free survival (RFS) overall (OS) examined based on stage. Propensity scores created using eight variables (age, sex, T stage, N histologic grade, presence lymphovascular invasion/perineural invasion, microsatellite instability...
To support the implementation of a patient safety system in community pharmacies, Korean Pharmaceutical Association (KPA) had established regional center (RPSC) 2018. Since 2019, KPA’s RPSC has participated preliminary project Korea Institute for Healthcare Accreditation (KOIHA) and made an effort to activate voluntary incident reporting pharmacies through ‘KPA SafePharm System’ modification development manual pharmacists. In addition, conducted campaigns improve culture, built cooperative...
Abstract Background: Trastuzumab deruxtecan (T-DXd) has been approved in various types cancer and recently expanded its indication to cancers with HER2 expressions, such as HER2-low breast cancer. Since the effect of T-DXd is based on toxin payload, topoisomerase I inhibitor, emergence toxin-resistant cells unavoidable. Clinical cases Primary, or secondary resistance have reported. Therefore, it necessary develop novel drugs that can effectively exhibit antitumor effects against...