Abstract The past few years have witnessed a fast-growing research interest on the study of sulfonyl fluorides as reactive probes in chemical biology and molecular pharmacology, which raises an urgent need for development effective synthetic methods to expand toolkit. Herein, we present invention facile general approach synthesis aliphatic via visible-light-mediated decarboxylative fluorosulfonylethylation. method is based abundant carboxylic acid feed stock, applicable various alkyl acids...

A visible-light-mediated deaminative thioesterification of amino acid derived Katritzky salts with thiobenzoic has been developed, which provides a novel synthetic method for the synthesis α-mercapto derivatives under mild conditions. This photoredox catalyst-free generation alkyl radicals via C-N bond cleavage is enabled by formation an electron-donor-acceptor (EDA) complex between salt and anion, represents new entry EDA chemistry.

Sulfonyl fluorides have widespread applications in many fields. In particular, their unique biological activity has drawn considerable research interest the context of chemical biology and drug discovery past years. Therefore, new efficient methods for synthesis sulfonyl are highly demand. contrast to extensive studies on FSO2+ -type reagents, a radical fluorosulfonylation reaction with fluorosulfonyl (FSO2. ) remains elusive so far, probably owing its instability difficulty generation....

Sulfonyl fluorides have widespread applications in many important fields, including ligation chemistry, chemical biology, and drug discovery. Therefore, new methods to increase the synthetic efficiency expand available structures of sulfonyl are highly demand. Here, we introduce a powerful class fluoride hubs, β-chloro alkenylsulfonyl (BCASF), which can be constructed via radical chloro-fluorosulfonyl difunctionalization alkynes under photoredox conditions. BCASF molecules exhibit versatile...

Abstract Sulfonyl fluorides have attracted considerable and growing research interests from various disciplines, which raises a high demand for novel effective methods to access this class of compounds. Radical flurosulfonylation is recently emerging as promising approach the synthesis sulfonyl fluorides. However, scope applicable substrate reaction types are severely restricted by limited known radical reagents. Here, we introduce solid state, redox-active type fluorosulfonyl reagents,...

Thioesters and related thiols are critically important to biological systems also widely employed in the synthesis of pharmaceutically molecules polymeric materials. However, known synthetic methods often suffer from disadvantage being specific only certain substrates. Herein, we describe a facile decarboxylative thioesterification alkyl acid derived redox-active esters by merging photoredox catalysis copper catalysis. This reaction is applicable wide range carboxylic acids, as well natural...

Abstract Thiols are important precursors for the synthesis of a variety pharmaceutically sulfur-containing compounds. In view versatile reactivity free thiols, here we report development visible light-mediated direct decarboxylative thiolation reaction alkyl redox-active esters to thiols based on abundant carboxylic acid feedstock. This transformation is applicable various acids, including primary, secondary, and tertiary acids as well natural products drugs, forging general facile access...

Abstract Sulfonyl fluorides have widespread applications in many fields. In particular, their unique biological activity has drawn considerable research interest the context of chemical biology and drug discovery past years. Therefore, new efficient methods for synthesis sulfonyl are highly demand. contrast to extensive studies on FSO 2 + ‐type reagents, a radical fluorosulfonylation reaction with fluorosulfonyl (FSO . ) remains elusive so far, probably owing its instability difficulty...

A visible light-mediated dehydrosulfurization of thioamides to nitriles is demonstrated, using an organic dye as a photocatalyst and air oxidant.

A direct palladium-catalyzed γ-lactonization of free carboxylic acids via C–O reductive elimination as a key step is described. Notable aspects this protocol include the use convenient and easily available sodium percarbonate an oxidant development new beta-alanine derived ligand. The reported method enables functionalization wide range aliphatic including previously inaccessible β-non-quaternary acids. regioselectivity consequently substrate scope proved complementary to established routes...

Abstract Sulfonyl fluorides have widespread applications in many important fields, including ligation chemistry, chemical biology, and drug discovery. Therefore, new methods to increase the synthetic efficiency expand available structures of sulfonyl are highly demand. Here, we introduce a powerful class fluoride hubs, β‐chloro alkenylsulfonyl (BCASF), which can be constructed via radical chloro‐fluorosulfonyl difunctionalization alkynes under photoredox conditions. BCASF molecules exhibit...

A direct palladium-catalyzed γ-lactonization of free carboxylic acids via C–O reductive elimination as a key step is described. Notable aspects this protocol include the use convenient and easily available sodium percarbonate an oxidant development new beta-alanine derived ligand. The reported method enables functionalization wide range aliphatic including previously inaccessible β-non-quaternary acids. regioselectivity consequently substrate scope proved complementary to established routes...