A5075854741- Fullerene Chemistry and Applications
- Carbon Nanotubes in Composites
- Graphene research and applications
- Synthesis and Properties of Aromatic Compounds
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Cancer-related cognitive impairment studies
- Nanoparticle-Based Drug Delivery
- Diamond and Carbon-based Materials Research
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Advanced Chemical Physics Studies
National Science Center
2025
University of Science and Technology of China
2012-2023
Hefei National Center for Physical Sciences at Nanoscale
2012-2022
Hefei University
2014-2015
Collaborative Innovation Center of Chemistry for Energy Materials
2015
Microscale (United States)
2015
Lanzhou University
2013
The spleen emerges as a pivotal target for mRNA delivery, prompting continual quest specialized and efficient lipid nanoparticles (LNPs) designed to enhance spleen-selective transfection efficiency. Here we report imidazole-containing ionizable lipids (IMILs) that demonstrate pronounced preference delivery into the with exceptional We optimized IMIL structures by constructing screening multidimensional library containing multiple heads, tails, linkers perform structure–activity correlation...
Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape through multiple mechanisms including suppressing antitumor activities of T lymphocytes. However, therapeutic abrogation MDSCs often causes severe adverse effects, compensatory recruitment alternative cell populations, and the multiplicity complexity relevant cytokines/receptors. Alternatively, expansion trafficking may be a proficient safe way for cancer treatment. Here we report that pseudoneutrophil cytokine sponges...
A cuprous bromide-catalyzed heteroannulation reaction of [60]fullerene with ketoxime acetates has been exploited to prepare novel 1-fulleropyrrolines through the cleavage N-O and C-H bonds formation C-C C-N under thermal conditions. plausible mechanism for is proposed on basis experimental results. The electrochemistry obtained products also investigated.
The FeCl3-mediated reaction of [60]fullerene with N-benzhydryl sulfonamides afforded C60-fused indane derivatives using the high-speed vibration milling technique. A possible mechanism involving unprecedented homolytic C–N bond cleavage is proposed. electrochemistry obtained indanes was also investigated.
Photothermal immunotherapy (PTI) is valuable for precise tumor targeting and immune activation. However, its efficacy hindered by insufficient response, elevated antioxidant levels within tumor, intrinsic resistance mechanisms. This study introduces Vitamin C (VC), a widely available dietary nutrient, as an effective enhancer PTI. High-dose VC induces oxidative imbalance in cells, making them more susceptible to nanoenabled near-infrared-II photothermal therapy (NIR-II PTT) with the...
The palladium-catalysed heteroannulation of [60]fullerene with various N-benzyl sulfonamides via C-H bond activation affords [60]fullerene-fused tetrahydroisoquinolines. In the presence a Brønsted acid tetrahydroisoquinolines are transformed to indanes, in which sulfonamide group can be removed or replaced an aryl group.
The palladium-catalyzed heteroannulation of [60]fullerene with<italic>N</italic>-(2-arylethyl) sulfonamides<italic>via</italic>C–H activation affords [60]fullerene-fused tetrahydrobenzazepines, which can be further functionalized.
Abstract Protein drugs hold promise in treating multiple complex diseases, including cancer. The priority of protein drug application is precise delivery substantial bioactive into tumor site. Metal–organic‐framework (MOF) widely considered as a promising carrier to encapsulate owing the noncovalent interaction between and protein. However, limited loading efficiency potential toxicity metal ion MOF restrict its clinical research. Herein, targeted collagenase‐encapsulating via protein‐metal...
The palladium-catalyzed three-component 1,4-aminoarylation of [60]fullerene afforded 1,4-(aryl)(sulfonamide)[60]fullerenes, which the sulfonamide group could be replaced by a (hetero)aryl, malonate ester or allyl in presence FeCl 3 .
The palladium-catalyzed three-component alkoxyarylation reaction of [60]fullerene with primary/secondary alcohols and aryl iodides generates a series 1,4-(alkoxy)(aryl)[60]fullerene derivatives. Plausible pathways for the formation 1,4-(alkoxy)(aryl)[60]fullerenes are proposed. In addition, electrochemical properties synthesized 1,4-alkoxyarylation adducts investigated.
Abstract Novel 1‐fulleropyrrolines are synthesized by a copper bromide‐catalyzed heteroannulation reaction of [60]fullerene with ketoxime acetates through the cleavage N—O and C—H bonds formation C—C C—N under thermal conditions.
Abstract The sulfonamide group in derivative (IVa) can be easily removed or replaced under standard conditions.