A5065538162- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Bone Tumor Diagnosis and Treatments
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Musculoskeletal synovial abnormalities and treatments
- Venous Thromboembolism Diagnosis and Management
- Hip disorders and treatments
- Mesenchymal stem cell research
- Bone fractures and treatments
- Acute Myocardial Infarction Research
- Shoulder Injury and Treatment
- Bone and Joint Diseases
- Oral and Maxillofacial Pathology
- Cardiac tumors and thrombi
- Anesthesia and Pain Management
- Surgical site infection prevention
- Bone Tissue Engineering Materials
- Orthopedic Surgery and Rehabilitation
- Management of metastatic bone disease
- Medical Imaging and Pathology Studies
- Periodontal Regeneration and Treatments
- Atrial Fibrillation Management and Outcomes
National Yang Ming Chiao Tung University
2016-2025
Taipei Veterans General Hospital
2016-2025
University of Taipei
2023-2024
Nanjing Drum Tower Hospital
2024
National Yang Ming University Hospital
2011-2020
National Taipei University
2014-2020
Mitsubishi Corporation (Japan)
2016
Jacobson Holman (United States)
2016
Bridge University
2016
National Hsinchu University of Education
2016
Osteosarcoma is the most common primary malignant bone tumor. The long-term outcome poor for patients with metastatic disease. From June 1989 to January 2008, 202 (128 males and 74 females) high-grade osteosarcoma of extremities were treated at our institution. Patients divided into three groups depending on time identification pulmonary metastasis: group A, identified tumor diagnosis; B, during whole treatment course; C, after completion treatment. Long-term survival was calculated factors...
Abstract Background Immediately recycling the resected bone segment in a biologic limb salvage reconstruction is an option after wide resection of bone. Intraoperative extracorporeal irradiation and freezing are two major tumor-killing techniques applied on fresh tumor-bearing autografts. However, graft-derived tumor recurrence complications concerns affecting graft survival. Questions/Purposes We therefore asked: (1) Is there difference proportion patients achieving union by 18 months...
Abstract Objective To evaluate the safety and efficacy of intra-articular (IA) injection allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE® for knee osteoarthritis. Methods This was a patient-blind, randomized, active-control trial consisted 4 arms including hyaluronic acid (HA) control 3 doses. A total 64 subjects were screened, 57 randomized. The primary endpoints included changes from baseline to post-treatment visit Western Ontario McMaster Universities Osteoarthritis Index (WOMAC)...
Purpose . High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate precise creation and distraction osteotomized wedges use intraoperative X-ray images to continually monitor wedge-related manipulation. Thus HTO is highly technique-demanding a high radiation exposure. We report patient-specific instrument (PSI) guide wedge. Methods This study first parameterized five procedures...
Simultaneous bilateral total knee arthroplasty (TKA) might be associated with higher postoperative morbidity and mortality rates compared staged TKA. However, risk factors for surgical complications reoperations following simultaneous TKA remain elusive. We conducted this retrospective, single-surgeon case series from 2010 through 2019. A of 1561 patients who underwent procedures were included. The outcome domains included 30-day 90-day readmission events medical or 1-year reoperation...
When managing aggressive giant cell tumor of bone (GCTB) around the knee joint, surgeons are often caught in a dilemma when determining whether to perform marginal excision or intralesional curettage. The purpose this study was report long-term results different treatment strategies our institute. We retrospectively reviewed 64 eligible cases (34 female and 30 male) with GCTB (37 distal femur, 27 proximal tibia) treated from 2002 2013. Forty patients received curettage (group A). Twenty-four...
Chondrosarcoma is a type of highly malignant tumor with potent capacity to invade locally and cause distant metastasis. shows predilection for metastasis the lungs. IL-6 multifunctional cytokine that associated disease status outcomes cancers. However, effect on migration activity human chondrosarcoma cells mostly unknown. Here, we found increased expression MMP-13 in cells. We also tissues had significant IL-6, which was higher than normal cartilage. IL-6-mediated up-regulation were...
Osteonecrosis of the femoral head (ONFH) is an important indication for total hip arthroplasty in Taiwan. We demonstrated etiologies ONFH and outcomes based on stratification patients according to different etiologies.We reviewed medical records images from January 2000 May 2010 our database with diagnosis "osteonecrosis head." categorized all into etiologies, including corticosteroid, alcohol, idiopathic. All received subsequent follow up ipsilateral precollapse contralateral disease-free...
Total knee arthroplasty (TKA) improves the patient's quality of life by relieving pain, correcting deformity, and helping patient resume normal activities. However, post-TKA prosthetic joint infection leads to implant failure, is difficult treat, causes a significant burden both economically health-wise. Therefore, an understanding current trends in this microbiology data essential for preventing treating it.A retrospective study was conducted on 10,768 patients who underwent primary TKA at...
The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. 3 + phase I was designed two dose-escalation cohorts: low dose (6.7 × 10 6 GXCPC1, N = 5) high (4 7 6). primary endpoint safety, which evaluated by recording adverse events throughout trial; secondary endpoints included total, pain, stiffness, function subscales...
Deep vein thrombosis (DVT) is an important complication following total knee arthroplasty (TKA). However, the incidence of DVT generally underestimated due to subclinical or minor symptoms and signs. In Western countries, prophylactic agents against are administered routinely after TKA. in Asia, no regular prophylaxis given patients undergoing This article presents a prospective study evaluating 724 consecutive Taiwanese who underwent TKA without anticoagulation therapy. Of these, 328...
Abstract Cell therapies using human mesenchymal stem cells (MSCs) have received much attention in the past decade. In pursuit of therapeutic potential MSCs, cell expansion is required to generate a great number with desired phenotype and functionality. Long-term vitro, however, can lead altered functions. To explore changes DNA damage responses (DDR) MSCs expanded, DDR pathways following irradiation were characterized early- late-passage bone marrow MSCs. Seventy-two hours after irradiation,...
The aim of this study was to compare survival before and after 2004 define the prognostic factors for high-grade osteosarcomas beyond those typical young patients with localized extremity disease. Few studies have reported long-term treatment outcomes osteosarcoma in Taiwan. A total 202 primary who received chemotherapy at Taipei Veterans General Hospital between January 1995 December 2011 were retrospectively evaluated compared by period (1995–2003 vs 2004–2011). Patients all ages tumor...
Abstract Background and Objectives Wide excision with a 2–3 cm safe margin is widely‐accepted in treating high‐grade osteosarcoma. However, wider sacrifices more healthy bone may jeopardize joint function. We hypothesize that our innovative hemicortical resection for such tumors leads to better function without higher recurrence rate. Methods Between August 2002 April 2007, six patients of osteosarcoma were treated biological reconstruction. Results Five located around the knee one was...
Background: Treatment options for nonunion of the femoral shaft fracture after intramedullary nail fixation are controversial. The methods exchanging an existing with a larger-sized nail, dynamization, removal followed by plating, and bone grafting have all been reported. From those options, exchange nailing seems to be most popular choice. In our study, we used plate augmentation retention nail. purpose study was evaluate effectiveness this method in treating open reduction internal...
The aim of this study was to review the experience surgical treatment low-grade chondrosarcoma and assess long-term oncological functional outcomes between intralesional curettage wide excision.We included 11 patients with central lesions treated or excision from 1998 2013. Seven were local adjuvant (Group A), four reconstructive surgery B). mean age 43.8±17.6 years (range, 20-71 years), duration follow-up 84.4±47.6 months 48-194 months).Group A had a significantly lower complication rate...