A5068420782- Pluripotent Stem Cells Research
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Renal function and acid-base balance
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- CRISPR and Genetic Engineering
- Nutritional Studies and Diet
- Neurogenesis and neuroplasticity mechanisms
- Sodium Intake and Health
- Body Image and Dysmorphia Studies
- Biomedical Ethics and Regulation
- Neurological disorders and treatments
- Liver Disease Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Bariatric Surgery and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
University College London
2024-2025
MRC Protein Phosphorylation and Ubiquitylation Unit
2021-2024
University of Dundee
2021-2024
King's College London
2023-2024
The Tavistock and Portman NHS Foundation Trust
2023
Cancer Research UK Manchester Institute
2016-2021
University of Manchester
2016-2021
Southampton General Hospital
2019
University of Southampton
2015-2019
University of Southern California
2003-2005
Studies have suggested that there are beneficial effects of exercise in patients with Parkinson's disease, but the underlying molecular mechanisms responsible for these poorly understood. rodent models provide a means to examine on dopaminergic neurotransmission. Using intensive treadmill exercise, we determined changes striatal dopamine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse. C57BL/6J mice were divided into four groups: (1) saline, (2) saline plus (3) MPTP, and...
Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and characterization of their heterocellular relationships remains incomplete. Using mass cytometry, we chart the stromal composition 18 murine tissues 5 spontaneous tumor models, with an emphasis on mesenchymal phenotypes. This analysis reveals heterogeneity across tumors, identifies coordinated between immune cell subsets in pancreatic ductal adenocarcinoma. Expression CD105 demarks two stable...
Abstract Physical activity has been shown to be neuroprotective in lesions affecting the basal ganglia. Using a treadmill exercise paradigm, we investigated effect of on neurorestoration. The 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐lesioned mouse model provides means investigate neurorestoration because 30–40% nigrostriatal dopaminergic neurons survive MPTP lesioning and may provide template for occur. MPTP‐lesioned C57 BL/6J mice were administered (four injections 20 mg/kg...
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with complex microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however effects of individual stromal subsets remain incompletely characterised. Here, we describe how heterocellular Oncostatin M (OSM) - Receptor (OSMR) signalling reprograms fibroblasts, regulates growth metastasis. Macrophage-secreted OSM stimulates inflammatory gene expression in...
Administration of the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading cell death and depletion striatal dopamine. After MPTP lesioning in young adult mice, surviving neurons display robust reproducible return dopamine weeks months after injury. Thus, mouse provides an excellent model with which investigate mechanisms underlying neuroplasticity system following neurotoxic The purpose this study was analyze...
Effects of isocaloric changes in dietary fat and carbohydrate on plasma apolipoproteins (apo) (2-11, C-111, lipoproteins were assessed nine healthy men.Carbohydrate comprised 80% total calories.After a 1-week basal diet (40% calories from carbohydrate), the subjects received either high (65% calories) or low (15% for 3 weeks; subsequently diets switched, those initially going to carbohydrate, vice versa, new maintained weeks.ApoC-11, triglycerides rose then declined during period; density...
The generation of distinct cell fates during development depends on asymmetric division progenitor cells. In the central and peripheral nervous system Drosophila, cells respectively called neuroblasts or sensory organ precursors use PAR polarity mitosis to control fate determination in their daughter How cycle are coupled, how machinery regulates protein function is poorly understood. Here, we generate an analog sensitive allele CDK1 reveal that its partial inhibition weakens but does not...
Abstract The neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) provides an excellent opportunity to study repair and response injury in the basal ganglia. Administration mammals leads destruction of nigrostriatal dopaminergic neurons depletion striatal dopamine. In squirrel monkey ( Saimiri sciureus ), MPTP‐lesioning results parkinsonian motor symptoms including bradykinesia, postural instability, rigidity. Over time animals display behavioral recovery. To better understand...
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives embryonic (hESCs) in regenerative medicine and disease modelling, thereby avoiding many of the ethical issues arising from use embryo-derived cells. However, despite clear similarities between two cell types, it is likely they are not identical. In this study, we characterise proteomes multiple hiPSC hESC lines derived independent donors. We find that while hESCs hiPSCs express a near identical set...
Abstract Defining the selective pattern of synapse replacement that occurs in different areas damaged brain is essential for predicting limits functional compensation can be achieved after various types injury. Here we describe time course dendritic reorganization, spine loss and recovery, striatum following a unilateral cortex ablation. We found transient recovery spines on medium spiny I (MSI) neurons, primary postsynaptic target corticostriatal axons, paralleled removal degenerating axon...