A5000246632- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- Biosimilars and Bioanalytical Methods
- Chemotherapy-related skin toxicity
- Eosinophilic Disorders and Syndromes
- Pharmacovigilance and Adverse Drug Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infectious Diseases and Mycology
- Body Image and Dysmorphia Studies
- Medical research and treatments
- Pharmaceutical studies and practices
- Nephrotoxicity and Medicinal Plants
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Health, Education, and Aging
- Ocular Diseases and Behçet’s Syndrome
University of Coimbra
2013-2023
Hospitais da Universidade de Coimbra
2016-2022
HLA-B*58:01 is associated with allopurinol-induced severe cutaneous adverse drug reactions (sCADR) particularly in Han Chinese, but the risk European populations has seldom been studied.To study association of sCADR a Portuguese population.We studied 25 patients (11 male/14 female, mean age 67·4 years) sCARD from allopurinol: 19 DRESS (drug reaction eosinophilia and systemic symptoms) six Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). HLA was genotyped by reverse...
Background Antibiotics are among the most frequent causes of cutaneous adverse drug reactions (CADR); patch testing may be an important tool in their evaluation and management. We assessed role as a diagnostic non-immediate CADR to antibiotics, evaluated cross-reactivity them. Methods reviewed data from all patients with attributed which were tested between 2000 2014 at our dermatology department. Results Patch tests performed 260 patients, showed overall reactivity antibiotics 21.5%,...
Objetivo: Relatar e comparar métodos contraceptivos (progestágenos), seus tipos vias de administração relacionando-as com incidência osteopenia. Detalhamento caso: Trata-se um relato caso, onde uma paciente 34 anos, em seguimento devido a NIC 2/3, sem fatores risco fraturas, comorbidades, uso prolongado (14 anos), acetato medroxiprogesterona. Devido este fato, foi investigado osteoporose por meio densitometria óssea. Obteve-se como resultado da densitometria, osteopenia, isso se deve...
Inpatients with cutaneous adverse drug reactions (CADR) overlapping features between maculopapular exanthema (MPE) and reaction eosinophilia systemic symptoms (DRESS) were examined.To characterize patients few not meeting the criteria for DRESS [overlapping MPE-DRESS (MP/DR)].We undertook a comparative analysis of clinical laboratory MPE, MP/DR (2008-12).We identified 132 inpatients (85 women/47 men, mean age 64·0 ± 17·7 years) CADR, 37 DRESS, 28 34 33 other patterns. There no significant...
The development of vaccines to prevent COVID-19 breakouts came with highly positive results but some unexpected side effects. Rare effects have been seen the BNT162b2 SARS-CoV 2 vaccine.We present case a 45-year-old female patient who developed an acute kidney injury needing urgent hemodialysis one week after second administration vaccine. She macular rash on her lower limbs and palms as well. A biopsy was performed 10 days vaccine inoculation, diagnosing interstitial nephritis tubular...
Abstract Background Chronic urticaria (CU) is defined as recurrent lasting for more than 6 weeks. Objectives We aimed to characterize the phenotypes of patients with CU refractory standard dose anti-H1 antihistamine treatment and search clinical predictors poor disease control. Methods Retrospective collection data regarding characteristics, comorbidities, treatment, control all adult presenting Allergy Immunology Department during 1 year. Results Sixty-one were included, 74% females,...
Background.Anaphylaxis is a potentially fatal medical emergency.The frequency of hospital admissions for anaphylaxis seems to be increasing in the recent decades.Objective.Characterize patients admitted adult emergency department (ED) tertiary care over 10-year period, discriminating aetiologies, clinical features and therapy administered.Methods.Retrospective, descriptive inferential study, evaluating age, sex, Manchester triage system, suspected allergen, site allergen exposure,...
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced hypersensitivity reaction. We report case of DRESS in 17-year-old female caused by itraconazole, confirmed patch testing, that required treatment both corticotherapy cyclosporine. Our highlights the importance clinical suspicion this pediatric age novelty an antifungal drug being identified as culprit.
A relação entre asma e a COVID -19 ainda não está esclarecida.Neste artigo, revemos as publicações disponíveis sobre estas duas doenças à data de submissão do artigo.Os estudos preliminares encontraram uma associação definitiva o risco infeção por SARS -CoV -2 ou evolução para grave, embora existam diferenças importantes realizados em várias localizações.A parece ser causadora exacerbações asma, nem alguns sinais característicos como sibilância, têm sido descritos nos -19.A suscetibilidade...
AMA Pereira H, Alves M, Coutinho I, Carrapatoso Todo-Bom A. Hypocomplementemic urticarial vasculitis syndrome: a look beyond lesions. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(4):571-573. doi:10.5114/ada.2023.130474. APA Pereira, H., Alves, M., Coutinho, I., Carrapatoso, & Todo-Bom, (2023). Alergologii, 40(4), 571-573. https://doi.org/10.5114/ada.2023.130474 Chicago Helena Pires, Marta Pires Iolanda Alen Isabel Ana Todo-Bom. 2023. "Hypocomplementemic...
The authors declare no conflicts of interest.
Temporary henna tattoos have become increasingly popular, particularly among children and teenagers. The word “henna” is of Persian origin, it prepared from the plant Lawsonia inermis belonging to family Lythraceae. Concerning allergic reactions, natural paste rarely responsible for contact dermatitis, which more frequent if paraphenylenediamine (PPD) added paste. authors present a case female child with erythematous exanthems that appeared after application black tattoo. A diagnosis...
A mastocitose é uma doença rara com elevado risco para reações anafiláticas graves. Descrição do caso: Mulher que, aos 27 anos, desenvolveu choque anafilático durante um parto por cesariana. No perioperatório foram administrados lidocaína, ropivacaína, ocitocina, cefazolina e fentanilo. Os testes cutâneos positivos apenas à ocitocina (leitura imediata). Um ano mais tarde surgiram lesões cutâneas maculopapulares, vermelho -acastanhadas, pruriginosas, no tronco membros inferiores, sinal de...
Abstract Background: Chronic urticaria (CU) is defined as recurrent lasting for more than 6 weeks. Objectives: We aimed to characterize the phenotypesof patients with CU refractory standard dose anti-H1 antihistamine treatment and search clinical predictors of poor disease control. Methods: Retrospective collection data regarding characteristics, manifestations, comorbidities, treatment,and control all adult presenting Allergy Immunology Department during one year. Descriptive inferential...
Atopic dermatitis is a common illness in pediatric age.Children with atopic are prone to develop cutaneous sensitization due skin barrier dysfunction and immune dysregulation.Recent studies have shown higher prevalence of certain allergens, which identification may be clinically relevant implications for management.Considering the most prevalent allergens based on retrospective analysis 145 patients, 44,1% (n=63) dermatitis, comparing positive results, we propose application an adapted...