A5051173517- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Compounds Synthesis and Characterization
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Lanthanide and Transition Metal Complexes
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Protein Interaction Studies and Fluorescence Analysis
- Computational Drug Discovery Methods
- Inorganic and Organometallic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Crystallography and molecular interactions
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Bioactive Compounds and Antitumor Agents
- Inflammatory mediators and NSAID effects
- Chronic Lymphocytic Leukemia Research
- Analytical Chemistry and Chromatography
- Chronic Myeloid Leukemia Treatments
- Synthesis and Biological Evaluation
- Drug Transport and Resistance Mechanisms
- Nanocomposite Films for Food Packaging
University of Kragujevac
2015-2024
<italic>In vitro</italic>activity of ligands and corresponding platinum(<sc>ii</sc>) palladium(<sc>ii</sc>) complexes.
The numerous side effects of platinum based chemotherapy has led to the design new therapeutics with replaced by another transition metal. Here, we investigated interactions previously reported copper(II) complexes containing S-isoalkyl derivatives, salicylic acid guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) their antitumor effects, in a colon carcinoma model. All three exhibited an affinity for binding CT-DNA, but there was no indication intercalation or displacement ethidium...
S-isoalkyl derivatives of thiosalicylic acid (isopropyl-(L1), isobutyl-(L2) and isoamyl-(L3)) were selected in order to investigate the binding interaction with human serum albumin (HSA) using different spectroscopic methods molecular docking simulation. Association constants number sites used analyze quenching mechanism. The experimental results showed that fluorescence HSA by L1, L2 L3 occurs because static processes spontaneous, leading forces bonding hydrogen bonding, hydrophobic...
Abstract This study examined the effects of S-alkyl derivatives acute administration on local redox status and interaction between tested compounds antioxidant enzymes via molecular docking studies. included 88 male Wistar albino rats divided into three experimental groups, receiving different per os in doses (10 mg/kg, 15 20 mg/kg) two control CMC - treated with 1% carboxymethyl cellulose indomethacin group (IND) – mg/kg). Carrageenan-induced paw edema model was used for evaluation...
Aim: We investigated the antitumor effects of zinc(II) complex with S-propyl thiosalicylic acid [Zn(S-pr-thiosal)2] in 4T1 murine breast cancer model. Results: The Zn(S-pr-thiosal)2 reduced primary tumor growth vivo and induced cell apoptosis. disrupted balance between pro- antiapoptotic Bcl-2 family members cells G1/S cycle arrest. increased percentage p16, p21 p27 positive cells. There was a significantly decrease expression STAT3 its targets c-Myc cyclin D3 treated thus contributing to...