A5026178346- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Nanomaterials for catalytic reactions
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Organoselenium and organotellurium chemistry
- Synthesis and Biological Evaluation
- Organometallic Compounds Synthesis and Characterization
- Asymmetric Hydrogenation and Catalysis
- Protein Interaction Studies and Fluorescence Analysis
University of Kragujevac
2022-2025
A series of mono- and heteronuclear platinum(II) zinc(II) complexes with 4,4′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine ligand were synthesized characterized. The DNA protein binding properties [ZnCl2(terpytBu)] (C1), [{cis-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C2), [{trans-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C3), [{cis-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C4) [{trans-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C5) (where terpytBu =...
The modes of interaction monofunctional Zn( ii ) complexes with bispyrazolate ligands DNA and BSA biomolecules were investigated, alongside comparative cytotoxicity studies.
The numerous side effects of platinum based chemotherapy has led to the design new therapeutics with replaced by another transition metal. Here, we investigated interactions previously reported copper(II) complexes containing S-isoalkyl derivatives, salicylic acid guanosine-5′-monophosphate and calf thymus DNA (CT-DNA) their antitumor effects, in a colon carcinoma model. All three exhibited an affinity for binding CT-DNA, but there was no indication intercalation or displacement ethidium...
This study investigates the potential of using ionic liquids as cosolvents to enhance solubility and activity poorly soluble rhodium(III) complexes, particularly those with diene, pyridine derivatives, camphor-derived bis-pyrazolylpyridine ligands, in relation 5′-GMP, CT-DNA, HSA well their biological activity. Findings indicate that significantly increase substitution these complexes toward 5′-GMP while only marginally affecting DNA/HSA binding affinities molecular docking, further...
Cancer remains one of the most common diseases worldwide in terms deaths and claims many lives every day. Transition metal complexes are candidates development anticancer drugs, with cisplatin being used chemotherapy worldwide. Copper, an endogenous metal, is known for its pronounced redox potential nucleophilicity, especially when bound to biological molecules. Cu (II) were synthesized containing ethane‐1,2‐diamine as amine moiety pentane‐2,4‐dione and/or 1‐phenylbutane‐1,3‐dione,...
Abstract In this study, the new Schiff base bearing Se−Se bond and vanillin core in structure was synthesized from naturally occurring amino acid selenocystine as an aldehyde counterpart. Taking into account fact that synergy of different pharmacophores one molecular could bring interesting biological properties, synthetized compound screened for antimicrobial activities with respect to their minimum inhibitory concentracion (MIC) values bacteria fungi cultures, well binding interactions...
Three Schiff base Cu(II) complexes, (N,N?-bis(acetylacetone)- propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis- (benzoylacetone)propylenediimine)copper(II) [Cu(phacac2pn)] (2) and (N,N?-bis-(trifluoroacetylacetone)propylenediimine)copper(II) [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) bovine serum albumin (BSA) using electronic absorption spectroscopic fluorescence methods. UV-Vis studies showed that studied complexes interact...