A5102820988- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Advanced MRI Techniques and Applications
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Functional Brain Connectivity Studies
- Neutropenia and Cancer Infections
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Hemophilia Treatment and Research
- Advanced Neuroimaging Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Mobile Health and mHealth Applications
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Renin-Angiotensin System Studies
- Healthcare cost, quality, practices
- Hearing, Cochlea, Tinnitus, Genetics
- Opioid Use Disorder Treatment
- Clinical Laboratory Practices and Quality Control
Johns Hopkins University
2020-2023
Southern Illinois University School of Medicine
2013-2023
Johns Hopkins Hospital
2021-2023
Midwestern University
2022
University of Rochester
1986-2021
Tallaght University Hospital
2019
Memorial Medical Center
2016
University of Rochester Medical Center
1992-2015
Darlington Memorial Hospital
2014
St. James's Hospital
1991
The study of human B cell tolerance has been hampered by difficulties in identifying a sizable population autoreactive lymphocytes whose fate could be readily determined. Hypothesizing that cells expressing intrinsically antibodies encoded the VH4-34 heavy chain gene (VH4-34 cells) represent such population, we tracked healthy individuals. Here, show naive are positively selected and mostly restricted to follicular mantle zone. Subsequently, these largely excluded from germinal centers...
The study of human B cell tolerance has been hampered by difficulties in identifying a sizable population autoreactive lymphocytes whose fate could be readily determined. Hypothesizing that cells expressing intrinsically antibodies encoded the VH4-34 heavy chain gene (VH4-34 cells) represent such population, we tracked healthy individuals. Here, show naive are positively selected and mostly restricted to follicular mantle zone. Subsequently, these largely excluded from germinal centers...
Abstract The extensive proliferation that B lymphocytes undergo in germinal centers could compromise generation of long term cell memory if there occurs shortening the telomeres center cells with division. Telomere length, which is thought to act as a "mitotic clock" for somatic dictates cellular senescence, can be preserved by enzyme telomerase. Human tonsil consistently expressed 100- 1000-fold higher levels telomerase activity than naive or cells, had no very low detectable activity,...
Studies in animal models suggest that the integrin adhesion protein VLA-4 may play an important role lymphopoiesis. The relationship between cell and lymphopoiesis humans has been difficult to study because of relative rarity stringent vitro growth requirements lymphoid progenitors from normal adult human bone marrow. To determine functional significance VLA-4-mediated lymphopoiesis, we developed a culture system which marrow-derived adherent layer supports formation colonies terminal...
<h3>BACKGROUND AND PURPOSE:</h3> Resting-state fMRI helps identify neural networks in presurgical patients who may be limited their ability to undergo task-fMRI. The purpose of this study was determine the accuracy identifying language network from resting-state-fMRI independent component analysis (ICA) maps. <h3>MATERIALS METHODS:</h3> Through retrospective analysis, underwent both and task-fMRI were compared by data 3 reviewers. Blinded maps, these investigators independently reviewed ICA...
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating concentrations and essential hypertension. frequencies 235T allele are significantly different in black white subjects. We analyzed independent contribution development recurrent coronary events (coronary-related death, nonfatal myocardial infarction, or unstable angina) a cohort 916 (n=145) (n=771) postmyocardial infarction patients who were prospectively studied during an average...
Rats were given enemas of Gastrografin in two strengths, Renografin--76, and Tween--80 a 10% dilution. There no deleterious effects on the colons with these media used volumes to fill colon. Severe changes resulted from which produced overdistention.
Patients with chronic myelogenous leukemia (CML) can be cured allogeneic bone marrow transplantation. Over the past decade, it has become clear that immunological mechanisms, in form of graft-versus-leukemia, constitute an integral part this therapy. Because limitations imposed by a lack suitable donors, age, and toxicity, only minority patients offered transplantation (BMT). Recently, attempts have been made to employ autologous (ABMT) for therapy CML using variety pre- post-transplantation...