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Stephanie Tye

ORCID: 0000-0002-2546-8393
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About
Contact & Profiles
A5025938676
Research Areas
  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • Genomics and Chromatin Dynamics

Imperial College London
 2019-2024

The Francis Crick Institute
 2024

 Isomerization of BRCA1–BARD1 promotes replication fork protection
OPENALEX - Publications 
Manuel Daza-Martín Katarzyna Starowicz Mohammed Jamshad Stephanie Tye George E. Ronson and 12 more Hannah L. Mackay Anoop Singh Chauhan Alexandra K. Walker Helen R Stone James Beesley Jennifer Coles Alexander J. Garvin Grant S. Stewart Thomas J. McCorvie Xiaodong Zhang Ruth M. Densham Joanna R. Morris

10.1038/s41586-019-1363-4 article EN Nature 2019-07-01
 Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork
OPENALEX - Publications 
Emma L. Ryder Nazia Nasir Amy E O Durgan Michael Jenkyn-Bedford Stephanie Tye and 2 more Xiaodong Zhang Qian Wu

Abstract DNA damage that obstructs the replication machinery poses a significant threat to genome stability. Replication-coupled repair mechanisms safeguard stalled forks by coordinating proteins involved in response (DDR) and replication. SLF1 (SMC5–SMC6 complex localization factor 1) is crucial for facilitating recruitment of SMC5/6 sites through interactions with SLF2, RAD18, nucleosomes. However, structural SLF1’s are unclear. In this study, we determined crystal structure ankyrin repeat...

10.1093/nar/gkae831 article EN cc-by Nucleic Acids Research 2024-10-03
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