A5019132594- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- Hedgehog Signaling Pathway Studies
- Insect and Arachnid Ecology and Behavior
- Lipid metabolism and biosynthesis
- Invertebrate Immune Response Mechanisms
- Gastrointestinal motility and disorders
- Clinical Nutrition and Gastroenterology
- Developmental Biology and Gene Regulation
- Educational Methods and Impacts
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Lipid Membrane Structure and Behavior
- Genomics and Chromatin Dynamics
- Plant biochemistry and biosynthesis
Instituto Gulbenkian de Ciência
2015
Calouste Gulbenkian Foundation
2015
Max Planck Institute of Molecular Cell Biology and Genetics
2009-2015
Max Planck Institut für Zellbiologie
2015
Laboratoire de Physico-Chimie de l'Atmosphère
2014
Max Planck Society
2012
Interorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with metabolic disease. However, precisely how lipoproteins affect tissue composition has not been comprehensively analyzed. Here, we identify the major of Drosophila melanogaster use genetics mass spectrometry to study their assembly, interorgan trafficking, influence on lipids. The apoB-family Lipophorin (Lpp) is hemolymph carrier. It produced as a phospholipid-rich particle by fat body, its...
The high sterol concentration in eukaryotic cell membranes is thought to influence membrane properties such as permeability, fluidity and microdomain formation. Drosophila cannot synthesize sterols, but do require them for development. Does this simply reflect a requirement sterols steroid hormone biosynthesis, or bulk also essential Drosophila? If the latter true, how they survive fluctuations availability maintain homeostasis? Here, we show that both hormones order complete adult When...
In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes far from understood. Here, we show the intestine responds to nutrient availability regulating production of circulating lipoprotein-associated form signaling protein Hedgehog (Hh). Levels Hh tune rates Circulating signals fat body control larval growth. It regulates controlling ecdysteroid prothoracic gland. is especially important during...
Ecdysteroids are the hormones regulating development, physiology and fertility in arthropods, which synthesize them exclusively from dietary sterols. But how sterol diversity influences ecdysteroid profile, animals ensure production of desired whether there functional differences between different ecdysteroids produced vivo, remains unknown. This is because currently no analytical technology for unbiased, comprehensive quantitative assessment full complement endogenous ecdysteroids. We...
Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in wide variety of vertebrate invertebrate tissues. When Hh absent, its receptor Patched (Ptc) represses Smoothened (Smo) signaling by an unknown catalytic mechanism correlates with reduced Smo levels on the basolateral membrane. Ptc contains sterol-sensing domain similar to Niemann-Pick type C-1 protein, suggesting might regulate lipid trafficking repress Smo. However, no endogenous regulators have...
Animals in the wild live highly variable and unpredictable environments. This variation their habitat induces animals, at all stages of development, to make decisions about what eat, where live, with whom associate. Additionally, animals like insect show dramatic restructuring morphology across life stages, which is accompanied by alterations behaviour match stage-specific functions. Finally, a process called developmental plasticity, environmental conditions feedback onto mechanisms...
Abstract In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes far from understood. Here, we show the intestine responds to nutrient availability regulating production of circulating lipoprotein-associated form signaling protein Hedgehog (Hh). Levels Hh tune rates Circulating signals fat body control larval growth. It regulates controlling ecdysteroid prothoracic gland. is especially...