A5080140997- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Science, Research, and Medicine
- Biomedical Ethics and Regulation
- Transplantation: Methods and Outcomes
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Biomedical and Engineering Education
- RNA Interference and Gene Delivery
- Advanced Fluorescence Microscopy Techniques
- biodegradable polymer synthesis and properties
Karolinska Institutet
2022
Tokyo Women's Medical University
2018
Duke University
2011
Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory pathways, effect of niche geometry is not well understood. We used organoids and bioengineered culture platforms to demonstrate that conical shape Lgr5 + small intestinal cells (ISCs) facilitate their self-renewal function. Inhibition non-muscle myosin II (NM II)–driven apical constriction altered ISC reduced curvature cell capacity. Niche decreased in aged mice, suggesting suboptimal interactions between old...
Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, tissue engineering. In this report, a simple method is presented synthesizing casting biocompatible polyurethane-poly(ethylene glycol) (PU-PEG) tunable mechanical properties, nonfouling characteristics, sustained tolerability as an implantable material or coating. The synthesized via...
Retention and survival of transplanted cells are major limitations to the efficacy regenerative medicine, with short-term paracrine signals being principal mechanism underlying current cell therapies for heart repair. Consequently, even improvements in durability may have a potential impact on cardiac grafting. We developed multimodal hydrogel-based platform comprised poly(ethylene glycol) network cross-linked bioactive peptides functionalized Gd(III) order monitor localization retention...