A5100752355- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Algal biology and biofuel production
- RNA modifications and cancer
- Psychological and Temporal Perspectives Research
- Nutrition, Genetics, and Disease
- Mechanisms of cancer metastasis
- Lymphatic System and Diseases
- Pharmacological Effects of Natural Compounds
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- Chemical Reactions and Isotopes
- Coenzyme Q10 studies and effects
- Vitamin C and Antioxidants Research
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Extracellular vesicles in disease
- Microtubule and mitosis dynamics
- Stress Responses and Cortisol
Second Affiliated Hospital of Nanjing Medical University
2025
Shanxi Medical University
2015-2024
First Hospital of Shanxi Medical University
2015-2024
TIMELESS (TIM) is a circadian gene which implicated in the regulation of daily rhythm, DNA replication and repair, cancer initiation progression. Nevertheless, role TIM endometrial (EC) development largely unknown. Bioinformatics analysis showed that was aberrantly up-regulated EC tissues positively correlated with clinical or histological grade EC. Functional studies knockdown reduced cell viability restrained migration vitro, as well blocked xenograft tumor growth vivo. Mechanistically,...
Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative the relevance across diverse tumors remain sparse. We comprehensively investigated effect expression on tumor prognosis human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and protein atlas (HPA). Bioinformatics data indicated that was...
The aim of the present study was to evaluate association between Period2 (Per2) and occurrence development ovarian cancer, in addition evaluating effect this gene on growth metastasis cancer nude mice xenograft models. detection Per2 by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting methods at various stages tumor tissue samples conducted. Nude models were constructed using an cell line and, a transfection technique, exogenous infusion recombinant...
Background: The mortality rate of ovarian cancer is the highest among gynecological tumors. two factors leading to high are late clinical stage and chemotherapy resistance. It very important reverse or intervene Abnormal circadian rhythm related occurrence tumor, clock protein PERIOD2 (PER2) acts as a tumor suppressor in cancer; however, little known about its involvement chemosensitivity. Methods: This study aimed investigate role underlying mechanisms PER2 sensitivity cisplatin....
The aim of the present study was to investigate protective effects interleukin-24 (IL-24) on hydrogen peroxide (H2O2)-induced vascular endothelial injury and examine association between IL-24 cardiovascular disease. Human umbilical vein cells (HUVECs) were exposed increasing concentrations H2O2 in presence or absence IL-24, which introduced via Lipofectamine® 2000-mediated transfection. successful uptake plasmid confirmed by RT-PCR at 24 h post-transfection. proliferation migration HUVECs...
Ovarian cancer is the most lethal in female reproductive system. It has been shown that 'time chemotherapy' of ovarian an important impact on chemotherapy effect and prognosis patients, but specific mechanism not known. We designed a case-control study strict accordance with epidemiological principles. collected resection samples patients who worked night-shifts those did not, analyzed differences protein expression. Through construction normal/circadian-rhythm disorder model nude mice, we...
Chronotherapy, a promising therapy, may build up the chemotherapy efficacy through thinking about timing of therapy. Here, we observed roles period circadian regulator 2 (PER2) on cervical cancer progression and therapeutic cisplatin (DDP) based rhythm PER2.
Abstract Background Circadian clock protein PERIOD2 (PER2) acts as a tumor suppressor in cancer; however, little is known about its involvement chemosensitivity. Methods This study aimed to investigate the role and underlying mechanisms of PER2 ovarian cancer sensitivity cisplatin. Overexpression knockdown were performed explore cell cisplatin both vitro vivo . The levels PI3K, AKT, caspase 3, E-cadherin, other drug resistance-related molecules determined parental SKOV3 SKOV3/DDP cells well...