A5101976164- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Ferroptosis and cancer prognosis
- GABA and Rice Research
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Pesticide Exposure and Toxicity
- Plant Surface Properties and Treatments
- Plant Gene Expression Analysis
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Plant Parasitism and Resistance
- Epigenetics and DNA Methylation
- Plant tissue culture and regeneration
- Seed Germination and Physiology
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Vestibular and auditory disorders
- Light effects on plants
- Arsenic contamination and mitigation
- Microbial bioremediation and biosurfactants
- Botanical Research and Applications
- Genetic Syndromes and Imprinting
Second Affiliated Hospital of Nanjing Medical University
2022-2025
Shanghai Jiao Tong University
2014-2024
Chengdu University of Traditional Chinese Medicine
2024
Shanghai First People's Hospital
2020-2024
Shenzhen Institutes of Advanced Technology
2024
Wannan Medical College
2022-2023
Zhejiang University
2023
Zunyi Medical University
2022
Guizhou University
2020
Sichuan Agricultural University
2013
An extraordinarily precise regulation of chlorophyll biosynthesis is essential for plant growth and development. However, our knowledge on the complex regulatory mechanisms very limited. Previous studies have demonstrated that miR171-targeted scarecrow-like proteins (SCL6/22/27) negatively regulate via an unknown mechanism. Here we showed SCLs inhibit expression key gene encoding protochlorophyllide oxidoreductase (POR) in light-grown plants, but no significant effect etiolated seedlings....
Seed metabolites are critically important both for plant development and human nutrition; however, the natural variation in their levels remains poorly characterized. Here we profiled 121 mature seeds of a wide panel Oryza sativajaponica indica cultivars, revealing correlations between metabolic phenotype geographic origin rice seeds. Moreover, japonica subspecies differed significantly not only relative abundances but also corresponding association networks. These findings provide insights...
Aliphatic and aromatic lipids are both essential structural components of the plant cuticle, an important interface between environment. Although cross links aliphatic or other moieties known to be associated with formation leaf cutin root seed suberin, contribution biosynthesis anther cuticles pollen walls remains elusive. In this study, we characterized rice (Oryza sativa) male sterile mutant, defective wall 2 (dpw2), which showed abnormal a wall, complete sterility. Compared wild type,...
Summary Degeneration of apical spikelets and reduced panicle fertility are common reasons for low seed‐setting rate in rice ( Oryza sativa ). However, little is known about the underlying molecular mechanisms. Here, we report a novel degenerated partial sterility 1 dps1 ) mutant that showed degeneration middle spikelets. plants were characterized by small whitish anthers with altered cuticle morphology absence pollen grains. Amounts cuticular wax cutin significantly anthers. Panicles an...
Male reproduction in higher plants requires the support of various metabolites, including lipid molecules produced innermost anther wall layer (the tapetum), but how are allocated among different tissues remains largely unknown. Previously, rice (Oryza sativa) ATP binding cassette G15 (ABCG15) and its Arabidopsis (Arabidopsis thaliana) ortholog were shown to be required for pollen exine formation. Here, we report significant role OsABCG26 regulating development cuticle together with OsABCG15...
Summary Environment‐sensitive genic male sterility (EGMS) lines are used widely in two‐line hybrid breeding rice ( Oryza sativa ). At present, photoperiod‐sensitive (PGMS) and thermo‐sensitive (TGMS) predominantly rice, with humidity‐sensitive (HGMS) rarely being reported. Here, it is shown that HUMIDITY‐SENSITIVE GENIC MALE STERILITY 1 HMS1 ), encoding a β‐ketoacyl‐CoA synthase, plays key roles the biosynthesis of very‐long‐chain fatty acids (VLCFAs) HGMS rice. The hms1 mutant displayed...
Aflatoxin B1 (AFB1) is extremely harmful to both humans and animals. Mitophagy a selective process of self-elimination has an important role in controlling mitochondrial quality. The present study aimed investigate the effect reactive oxygen species (ROS) accumulation on AFB1-induced mitophagy HepG2 cells provide new perspective from which design novel therapeutic strategies treat AFB1 poisoning. ROS release was induced with (10 μmol/L). Cell autophagy activity, membrane potential (MMP),...
Metastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis a crucial factor tumor invasion metastasis. Long noncoding RNAs (lncRNAs) play regulatory functions various biological processes cells, however, roles lncRNAs CRC-associated remain to be elucidated CRC, as do underlying mechanisms. We used bioinformatics screen differentially expressed from TCGA database. LOC101928222 expression was assessed by qRT-PCR. The impact CRC development both vitro...
Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative the relevance across diverse tumors remain sparse. We comprehensively investigated effect expression on tumor prognosis human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and protein atlas (HPA). Bioinformatics data indicated that was...
Colon adenocarcinoma (COAD) is one of the most frequent types cancer worldwide. Disulfidptosis has been identified as a new mode cell death recently. The goal this study was to explore possibility connection between disulfidptosis and COAD. RNA sequencing data from COAD patients were retrieved Cancer Genome Atlas (TCGA) database for investigation. R software various methods used identify disulfidptosis-related lncRNAs (DRLs) in COAD, prognostic model created based on 6 DRLs (AP003555.1,...
The plant cuticle, which consists of cutin and waxes, forms a hydrophobic coating covering the aerial surfaces all plants. It acts as an interface between plants their surrounding environment whilst also protecting them against biotic abiotic stresses. In this research, we have investigated biodiversity cuticle properties aquatic duckweed, using samples isolated from four different locations around Hongze lake in Jiangsu province, China. were genotyped two chloroplast markers nuclear...
Abstract Elucidation of the metabolic pathways determining pigmentation and their underlying regulatory mechanisms in maize kernels is high importance attempts to improve nutritional composition our food. In this study, we compared dynamics transcriptome metabolome between colored SW93 white SW48 by integrating RNA-Seq non-targeted metabolomics. Our data revealed that expression enzyme coding genes levels primary metabolites decreased gradually from 11 21 DAP, corresponding well with...
The methylcytosine dioxygenases TET proteins (TET1, TET2, and TET3) play important regulatory roles in neural function. In this study, we investigated the role of neuronal differentiation using Neuro2a cells as a model. We observed that knockdown TET1, TET2 or TET3 promoted cells, their overexpression inhibited VPA (valproic acid)-induced differentiation, suggesting all three negatively regulate cells. Interestingly, inducing activity protein is independent its enzymatic activity. Our...
Abstract Hair follicle dermal sheath (DS) harbors hair stem cells (hfDSCs), which can be recruited to replenish DS and papilla (DP). Cultured differentiate into various cell lineages in vitro. However, it is unclear how its plasticity modulated vivo. Wnt/β-catenin signaling plays an important role maintaining of required for HF development regeneration. Here we report that activation β-catenin generates ectopic outgrowth (EF) by reprogramming epidermal themselves, endows with inducing...
The impact of low light intensities on plant disease outbreaks represents a major challenge for global crop security, as it frequently results in significant yield losses. However, the underlying mechanisms effect defense are still poorly understood. Here, using an RNA-seq approach, we found that susceptibility tomato to Pseudomonas syringae pv. DC3000 (Pst DC3000) under was associated with oxidation-reduction process. Low conditions exacerbated Pst DC3000-induced reactive oxygen species...