A5045641208- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Animal Disease Management and Epidemiology
- Thyroid Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Fungal Plant Pathogen Control
- Pancreatic function and diabetes
- Obstructive Sleep Apnea Research
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Virology and Viral Diseases
- Zoonotic diseases and public health
- Glioma Diagnosis and Treatment
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Metabolism, Diabetes, and Cancer
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune responses and vaccinations
- Quinazolinone synthesis and applications
- Cancer, Hypoxia, and Metabolism
University of Catania
2014-2025
Università Campus Bio-Medico
2023-2024
Policlinico Universitario di Catania
2021-2023
Sapienza University of Rome
2008-2023
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"
2020-2021
University of Siena
2016-2020
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2018-2020
University of Pavia
2016-2017
Azienda Ospedaliera Sant'Andrea
2013
University of Naples Federico II
2004-2009
Mpox, caused by viruses of the genus Orthopoxvirus, is an emerging threat to human and animal health. With increasing urbanization more frequent interaction between humans wild animals, risk Mpox transmission has increased significantly. This review aims examine in depth epidemiology, pathogenesis, diagnosis with a special focus on recent discoveries advances understanding disease. Molecular mechanisms involved viral replication will be examined, as well factors associated interspecific...
Nonenzymatic glycation is increased in diabetes and leads to levels of glycated proteins. Most studies have focused on the role products vascular complications. Here, we investigated action human albumin (HGA) insulin signaling L6 skeletal muscle cells. Exposure these cells HGA inhibited insulin-stimulated glucose uptake glycogen synthase activity by 95 80%, respectively. These effects were time- dose-dependent, reaching a maximum after 12 h incubation with 0.1 mg/ml HGA. In contrast,...
Measles, a highly contagious disease primarily affecting children, carries serious health risks, including complications and mortality. Vaccination remains the most effective preventive measure against measles transmission. The COVID-19 pandemic has exacerbated challenges in surveillance immunization efforts, leaving millions of people exposed to preventable diseases such as measles. Globally accelerated campaigns are critical for achieving regional elimination goals mitigating risk...
The management of patients with Central Nervous System (CNS) malignancies relies on the appropriate classification these tumors. Recently, World Health Organization (WHO) has published new criteria underlining importance an accurate molecular characterization CNS malignancies, in order to integrate information generated by histology. Next generation sequencing (NGS) allows single step multiple genes, generating a comprehensive and specific mutational profile tumor tissue. We developed custom...
Abstract Granzyme B (GrB) is a serine proteinase known to be expressed by cytotoxic lymphocytes and induce, in presence of perforin (Pf), apoptosis target cells. Recently, GrB expression has been shown (often absence Pf) nonlymphoid cells, but its function not defined. In our study, we investigated Pf bladder cancer cell lines urothelial carcinoma (UC) tissues reverse transcription‐polymerase chain reaction (RT‐PCR), Western blot, ELISA, immunofluorescence immunohistochemistry. We also...
Hericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing large number modulatory effects on human physiology ranging from the strengthening immune system to improvement cognitive functions. In mice, dietary supplementation with H. prevents impairment spatial short‐term and visual recognition memory in an Alzheimer model. Intriguingly other neurobiological have recently been reported like effect neurite outgrowth differentiation PC12 cells. Until now no investigations...
Lipoblastoma-like tumor is a rare mesenchymal neoplasm, typically arising in the vulvar region of young women. Although it considered benign tumor, local recurrences and exceptionally distant metastases have been reported. Histological examination reveals well-circumscribed with lobulated pattern, composed mixture mature adipocytes, spindle cells lipoblasts set abundant myxoid stroma numerous thin-walled capillary-like vessels. Due to rarity this neoplasm its morphological resemblance other...
Human T-lymphotropic viruses (HTLVs) are deltaretroviruses infecting millions of individuals worldwide, with HTLV-1 and HTLV-2 being the most widespread clinically relevant types. is associated severe diseases such as adult T-cell leukemia/lymphoma (ATL) HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), while shows a lower pathogenic potential, occasional links to neurological disorders. HTLV-3 HTLV-4, identified in Central Africa, remain poorly characterized but...
Overexpression of the ped/pea-15 gene is a common feature type 2 diabetes.In present work, we show that transgenic mice ubiquitously overexpressing exhibited mildly elevated random-fed blood glucose levels and decreased tolerance.Treatment with 60% fat diet led to develop diabetes.Consistent insulin resistance in these mice, administration reduced by only 35% after 45 min, compared 70% control mice.In vivo, insulin-stimulated uptake was almost 50% muscle tissues accompanied protein kinase C␣...
Abstract Abstract: We investigated the ability of fatty acids to induce growth inhibition and apoptosis in human PaCa-44 pancreatic cancer cell line mechanism(s) underlying apoptosis. Butyric acid, α-linoleic docosahexaenoic acid (DHA) were supplemented at 200 μM concentration medium cultures. Our results showed that all inhibited growth, whereas only DHA induced An oxidative process was implicated by because butylated hydroxytoluene vitamin E prevented lipid peroxidation reversed...
Abstract Delivery of tumor-associated Ag-derived peptides in a high immunogenic form represents one the key issues for effective peptide-based cancer vaccine development. We report herein ability nonpathogenic filamentous bacteriophage fd virions to deliver HLA-A2-restricted MAGE-A10254–262- or MAGE-A3271–279-derived and elicit potent specific CTL responses vitro vivo. Interestingly, human anti-MAGE-A3271–279-specific CTLs were able kill MAGE-A3+ tumor cells, even if these cells naturally...
Inotuzumab ozogamicin (IO) is an anti-CD22 calicheamicin immunoconjugate that has been recently approved for the treatment of relapsed or refractory B-Acute Lymphoblastic Leukemia (r/r B-ALL). We employed both immortalized and primary cells derived from CD22-positive lymphoproliferative disorders to investigate signaling pathways contributing IO sensitivity resistance. found drug reduced proliferation rate cell lines expressing wild-type p53, but was remarkably less effective on exhibiting...