A5027080979- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Engineering Education and Curriculum Development
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Oral microbiology and periodontitis research
- Innovations in Concrete and Construction Materials
- Salivary Gland Disorders and Functions
- Autophagy in Disease and Therapy
- Concrete and Cement Materials Research
- RNA Research and Splicing
- Oral Health Pathology and Treatment
- Higher Education and Teaching Methods
- Innovative concrete reinforcement materials
Air Force Medical University
2022-2023
Beijing Jiaotong University
2022
Glioblastoma (GBM) is the most malignant tumor of central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role treatment GBM. However, major impediments to effective are postoperative recurrence acquired resistance chemoradiotherapy. Our previous studies confirm that Yin Yang 1 (YY1) highly expressed GBM, whereby it associated with cell dedifferentiation, survival, therapeutic resistance. Targeted delivery small interfering RNA (siRNA) without...
Periodontitis is the top reason for tooth loss, and smoking significantly increases severe periodontitis risk. Defective autophagy has been reported to play a vital role in periodontitis. This study aimed elucidate relationship between inflammation factors production nicotine-treated periodontal ligament stem cells (PDLSCs) underlying mechanism.In this study, transmission electron microscopy, immunofluorescence, mCherry-GFP-LC3 plasmid were used flux. The gene levels of long noncoding RNA...
Nicotine is a widely known addictive and toxic substance in cigarette that exacerbates periodontitis. However, its deleterious effects on dental stem cells subsequent implications tissue regeneration remain unclear. This study aimed to explore the of nicotine regenerative capacity human periodontal ligament (hPDLSCs) based transcriptomics proteomics, determined possible targeted genes associated with smoking-related hPDLSCs were treated different concentrations ranging from 10−3 10−8 M....
Glioma is the most common tumor of nervous system. The diffuse growth and proliferation glioma poses great challenges for its treatment. Here, Transcriptomic analysis revealed that Rac GTPase activating protein 1 (RACGAP1) highly expressed in glioma. RACGAP1 has been shown to play an important role malignant biological progression a variety tumors. However, underlying mechanism remain poorly understood. By using quantitative real-time polymerase chain reaction (qRT-PCR), western blot,...
To investigate the biaxial mechanical characteristics of reactive powder concrete (RPC), RPC plate specimens and bone‐shaped were tested under compression‐compression compression‐tension loadings, respectively. The strengths strains recorded, crack patterns failure modes in various stress states examined. Based on test data, strength analyzed, a criterion was established. major stress‐strain curves different determined. results show that ratio between compression uniaxial 1.44–1.58 for RPC....