A5054659240- Bone Tumor Diagnosis and Treatments
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral and Maxillofacial Pathology
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Congenital limb and hand anomalies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Medical and Biological Ozone Research
- Phytase and its Applications
- Health and Well-being Studies
- Connective tissue disorders research
- Neurogenetic and Muscular Disorders Research
- Plant biochemistry and biosynthesis
- Helicobacter pylori-related gastroenterology studies
- Resilience and Mental Health
China Pharmaceutical University
2024
Shanghai Children's Medical Center
2011-2023
Shanghai Jiao Tong University
2020-2023
University of Göttingen
2021-2023
Universitätsmedizin Göttingen
2021-2023
First Hospital of Shijiazhuang
2023
I-Shou University
2019-2022
Weatherford College
2022
Hebei University of Chinese Medicine
2019
Dongguan People’s Hospital
2019
Abstract Objective Infection with Helicobacter pylori ( H ), especially cytotoxin‐associated gene A‐positive (CagA+) strains, has been associated various gastrointestinal and extragastric diseases. The aim of this study was to characterize ‐induced alterations in the gastric tongue coating microbiota evaluate their potential impacts on human health. Design mucosa specimens were collected from 80 patients chronic gastritis, profiles generated by 16S rRNA sequencing. Samples grouped as...
Objective Pneumothorax (PTX) can be diagnosed using lung ultrasonography (LUS) in adult patients, but there are only a few reports of LUS PTX diagnosis neonates. The aim the study was to assess diagnostic accuracy for PTX. Study Design This retrospective review performed our neonatal intensive care unit (level III) between June 2015 and 2018. All eligible patients underwent an scan before undergoing chest X-ray (CXR), which considered reference standard. When inconsistent CXR, computed...
To characterize the serum metabolism in patients with Helicobacter pylori-positive and H. pylori-negative gastritis.Clinical data gastric function parameters, PGI (pepsinogen I), PGII, PGR (PGI/II), G-17 (gastrin-17) of 117 chronic gastritis were collected, including 57 pylori positive 60 negative subjects. Twenty cases each group randomly selected to collect intestinal mucosa specimens samples. The gut microbiota profiles generated by 16S rRNA gene sequencing, metabolites analyzed a...
ABSTRACT Growth and differentiation factors (GDFs) are secreted signaling molecules within the BMP family that have critical roles in joint morphogenesis during skeletal development mice humans. Using genetic data obtained from a six-generation Chinese family, we identified missense variant GDF6 (NP_001001557.1; p.Y444N) fully segregates with novel autosomal dominant synostoses (SYNS) phenotype, which designate as SYNS4. Affected individuals display bilateral wrist ankle deformities at birth...
Abstract Hepatocellular carcinoma (HCC) is a highly invasive malignancy. Recently, GATOR1 (Gap Activity TOward Rags 1) complexes have been shown to play an important role in regulating tumor growth. NPRL2 critical component of the complex. Therefore, this study used knockdown investigate how GATORC1 regulates prognosis and development HCC via mammalian target rapamycin (mTOR) autophagy signaling pathways. We established HepG2 cells with using small interfering RNA (siRNA) short hairpin...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers. Given currently limited therapeutic options, definition molecular subgroups with development tailored therapies promising strategy. Patients high-level gene amplification urokinase plasminogen activator receptor (uPAR/PLAUR) have an inferior prognosis. We analyzed uPAR function in PDAC to understand this understudied subgroup’s biology better. Methods: A total 67 samples clinical follow-up and TCGA...
We conducted a comprehensive study to investigate the role of genes involved in transport pathways response chemotherapy and clinical outcome osteosarcoma cases. Genotyping six SNPs was performed 384-well plate format on Sequenom MassARRAY platform for 208 patients reveal any correlations with outcome. Individuals ABCB1 rs1128503 TT ABCC3 rs4148416 genotypes had higher probability responding poorly chemotherapy, indicated by odds ratios (ORs) 2.46 (95%CI, 1.21-5.74) 3.78 (95% CI,...
Abstract Background Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an infrequent type of primary liver cancer that comprises (HCC) (CC). This study investigated the clinicopathological features prognosis among cHCC-CC, HCC, CC groups. Methods We prospectively collected data 608 patients who underwent surgical resection for between 2011 2018 at E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Overall, 505 with were included, their features, overall survival (OS),...
Hereditary multiple exostoses (HME) is a rare autosomal dominant skeletal disorder that can cause variety of clinical manifestations. We aimed to evaluate the general phenotypic severity HME by using scoring system and correlate genotypes with different phenotypes in Chinese patients. Forty-six patients from families were prospectively enrolled. The mutations identified direct sequencing PCR-amplified genomic DNA or multiplex ligation-dependent probe amplification (MLPA). Patients'...
Abstract Hereditary multiple osteochondroma (HMO) is one of the most common genetic skeletal disorders. It caused by mutations in either EXT1 or EXT2 resulting abnormal growth and morphogenesis. However, spectrum frequency Chinese patients with HMO was not previously investigated. Mutations were identified performing Sanger sequencing analysis complete coding regions flanking intronic sequences , followed multiplex ligation-dependent probe amplification (MLPA) to detect gene deletions...
To compare the bacterial flora in palpebral conjunctiva of xerophthalmia seniors Tibetan, Yi and Han, analyze differences similarities bacteria.The test subjects were selected from 2 3 Han populated places, respectively. Total 222 (444 eyes) with dry eye examined. Secretion was collected then inoculated onto a blood agar plate. After 48h incubation, bacteria examined for between different ethnics.There no significant difference (P>0.05) Gram stain characterization, dominant number species...
The forearm deformity classified by Masada is a characteristic trait of patients with hereditary multiple exostoses (HME). Ulnar gradual lengthening, which was considered to be safe and reliable procedure, popular in treating these difficult deformities, however, delayed consolidation the callus uncommon but not rare literature review. purpose this study try identify risk factors influencing bone healing ulnar lengthening HME.We retrospectively reviewed HME-induced who underwent at our...
Open reduction combined with ulnar osteotomy is the most common approach to treating missed Monteggia injuries. The usually performed at proximal ulna ensure better healing and fewer complications. purpose of this study present a center rotation angulation (CORA)-based for Bado type I We retrospectively reviewed cases patients who were treated open CORA-based between February 2014 December 2016. Each patient provided his or her internal control, paired data involved uninvolved sides analyzed...
Abstract Background The benefits of surgical resection (SR) for various Barcelona Clinic Liver Cancer (BCLC) stages hepatocellular carcinoma (HCC) remain unclear. We investigated the risk factors overall survival (OS) and SR over nonsurgical treatments in patients with HCC BCLC stages. Methods Overall, 2316 were included, their clinicopathological data OS recorded. was analyzed by Kaplan-Meier method Cox regression analysis. Propensity score matching (PSM) analysis performed. Results In...
Nitrate electroreduction to ammonia has broad prospects as a complementary route the energy-intensive Haber-Bosch industry. Currently, most electrocatalytic NO3−-to-NH3 transformations are achieved in alkaline electrolyte, which not only requires...
Abstract Background Gradual ulnar lengthening is the most commonly used procedure in treatment of Masada type I/II deformity patients with hereditary multiple osteochondromas. However, remains controversial for recurrence growing children. This study aims to evaluate clinical and radiological outcomes gradual our clinic. Methods We retrospectively reviewed who underwent by distraction osteogenesis from June 2008 October 2017. The carrying angle (CA) range motion (ROM) forearm elbow were...
To compare the status of bacteria in conjunctival sac from elder Qiang minority and Han people with dry eyes Sichuan, China.
The efficacy of sorafenib in combination with transarterial chemoembolization (TACE) or multiple-line therapies patients advanced hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate the overall survival (OS) HCC response different therapies.We analyzed treatment and OS 401 Barcelona clinic liver cancer stage C between 2012 2017. Mortality was using multivariate Cox regression, by Kaplan-Meier method.The mean age 59 years males were predominant. During a median...
Delays in the diagnosis of pediatric osteoarticular infections (OAIs) can cause associated acute complications or long-term morbidity. This study attempts to develop a multiplex PCR-based assay that rapidly and accurately detect main pathogens involved OAIs, namely, methicillin-sensitive methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes Pseudomonas aeruginosa.A set four gene-specific primers suitable for use one-tube PCR was designed common nuc mecA spyM orpI aeruginosa....
Abstract Background Autophagy-related proteins may predict postresection overall survival (OS) and disease-free (DFS) in patients with combined hepatocellular carcinoma cholangiocarcinoma (cHCC-CC). Methods We prospectively investigated how these affect clinical prognosis 40 who underwent hepatectomy for cHCC-CC from 2011 to 2019 at a Taiwanese hospital. Levels of autophagy-related proteins, namely LC3, Beclin-1, p62, were immunohistochemically assessed patient tumor non-tumor tissues....