A5006842699- CAR-T cell therapy research
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Cutaneous Melanoma Detection and Management
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- melanin and skin pigmentation
Cardiff University
2023-2024
Stem Cell Institute
2022
The basis of immune evasion, a hallmark cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous carcinoma. Here we showed that carcinoma tumor-initiating surface protein CD200, through ectodomain shedding, was responsible for near absence NK cells within tumor microenvironment. In situ, CD200 underwent shedding by metalloproteinases MMP3 MMP11, which released biologically active soluble into bound its cognate...
Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and saved millions of lives. Adenoviral (Ad) based vaccines played an integral part this vaccine campaign, with licensed on the simian Y25 isolate (Vaxzevria, Astrazeneca) human Ad type 26 (Jcovden, Janssen) widely adopted. As largest global vaccination programme ever undertaken, ultrarare thromboembolic events described approximately 1:200,000 vaccinees administered vaccines. Objectives: The...
Glioblastoma (GBM) is the most common and aggressive adult brain cancer with an average survival rate of around 15 months in patients receiving standard treatment. Oncolytic adenovirus expressing therapeutic transgenes represent a promising alternative treatment for GBM. Of many human adenoviral serotypes described to date, 5 (HAdV-C5) has been utilised clinically experimentally. However, use Ad5 as anti-cancer agent may be hampered by naturally high seroprevalence rates HAdV-C5 coupled...
Abstract Vaccination has proven to be a valuable tool combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia syndrome after ChAdOx1 nCoV-19 vaccination have caused scientific, public and media concern. was vectorised from the Y25 chimpanzee adenovirus, which selected due low human seroprevalence circumvent pre-existing immunity. In this study, we aimed explore patterns T-cell activation SARS-CoV-2 COVID-19 vaccine exposure in vitro using PBMCs...
Mutant BRAF targeted therapies remain a standard of care for the treatment metastatic malignant melanoma (MM); however, high initial response rates are tempered by persistence residual MM cells that eventually lead to disease recurrence and mortality. As during therapy can present with simultaneous occurrence multiple tumour nodules at original body sites, we hypothesized presence an intrinsically resistant cell subpopulation.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer care and shown remarkable efficacy clinically. This is, however, limited to subsets of patients with significant infiltration lymphocytes into the tumor microenvironment. To extend their who fail respond or achieve durable responses, it is now becoming evident that complex combinations immunomodulatory agents may be required immunologically “cold” tumours. Oncolytic viruses (OVs) capacity selectively replicate...
Glioblastoma (GBM) is the most common and aggressive adult brain cancer with an average survival rate of around 15 months in patients receiving standard treatment. Oncolytic adenovirus expressing therapeutic transgenes represent a promising alternative treatment for GBM. Of many human adenoviral serotypes described to date, 5 (Ad5) has been utilized clinically experimentally. However, use Ad5 as anti-cancer agent may be hampered by naturally high seroprevalence rates coupled infection...
Abstract Background RASopathies, which include neurofibromatosis type 1 (NF1), are defined by Ras/mitogen‐activated protein kinase (Ras/MAPK) pathway activation. They represent a group of clinically related disorders often characterised multiple Café au Lait Macules (CALMs). Objectives To determine, using in depth transcriptomic analysis NF1 melanocytes from CALM and unaffected skin, (1) the gene(s) responsible for melanocyte proliferation migration, (2) activated signalling pathway(s)...