A5009687116- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Herpesvirus Infections and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Signaling Pathways in Disease
- Poxvirus research and outbreaks
Cardiff University
2019-2023
Cancer Genetics (United States)
2019
Southern California University for Professional Studies
1992
University of Southern California
1992
Adenoviruses are clinically important agents. They cause respiratory distress, gastroenteritis, and epidemic keratoconjunctivitis. As non-enveloped, double-stranded DNA viruses, they easily manipulated, making them popular vectors for therapeutic applications, including vaccines. Species D adenovirus type 26 (HAdV-D26) is both a of EKC other diseases promising vaccine vector. HAdV-D26-derived vaccines under investigation as protective platforms against HIV, Zika, syncytial virus infections...
Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and saved millions of lives. Adenoviral (Ad) based vaccines played an integral part this vaccine campaign, with licensed on the simian Y25 isolate (Vaxzevria, Astrazeneca) human Ad type 26 (Jcovden, Janssen) widely adopted. As largest global vaccination programme ever undertaken, ultrarare thromboembolic events described approximately 1:200,000 vaccinees administered vaccines. Objectives: The...
Adenoviruses are powerful tools experimentally and clinically. To maximize efficacy, the development of serotypes with low preexisting levels immunity in population is desirable.
Oncolytic virotherapies (OV) hold immense clinical potential. OV based on human adenoviruses (HAdV) derived from HAdV with naturally low rates of pre-existing immunity will be beneficial for future translation. We generated a low-seroprevalence HAdV-D10 serotype vector incorporating an αvβ6 integrin-selective peptide, A20, to target αvβ6-positive tumor cell types. has limited natural tropism. Structural and biological studies knob protein highlighted low-affinity engagement native adenoviral...
Human adenoviruses (HAdV) are widespread pathogens causing usually mild infections. The Species D (HAdV-D) cause gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, knowledge around HAdV-D mechanism of cell infection is lacking. Sialic acid (SA) usage has been proposed as a for EKC HAdV-D. Here we highlight an important role SA engagement by many We provide apo state crystal structures 7 previously undetermined fiber-knob proteins,...
Abstract Adenoviruses are clinically important agents. They cause respiratory distress, gastroenteritis, and epidemic keratoconjunctivitis (EKC). As non-enveloped, double stranded DNA viruses, they easily manipulated, making them popular vectors for therapeutic applications, including vaccines. Species D adenovirus serotype 26 (HAdV-D26) is both a of EKC other disease, promising vaccine vector. HAdV-D26 derived vaccines under investigation as protective platforms against HIV, Zika, RSV...
Abstract Human adenoviruses (HAdV) are widespread pathogens causing infections of the respiratory and gastrointestinal tracts, genitourinary system eye. Species D (HAdV-D) most diverse species cause both tract epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, HAdV-D understudied knowledge around basic mechanisms cell infection is lacking. Sialic acid (SA) usage has been proposed as a major mechanism for EKC HAdV-D. Here, we provide apo state crystal structures fiber...
Abstract Human adenoviruses (HAdV) are widespread pathogens causing usually mild infections. The Species D (HAdV-D) cause gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, knowledge around HAdV-D mechanism of cell infection is lacking. Sialic acid (SA) usage has been proposed as a for EKC HAdV-D. Here we highlight an important role SA engagement by many We provide apo state crystal structures 7 previously undetermined fiber-knob...
Abstract The human adenovirus (HAdV) phylogenetic tree is diverse, divided across seven species and comprising over 100 individual types. Species D HAdV are rarely isolated with low rates of pre-existing immunity, making them appealing for therapeutic applications. Several vectors have been developed as vaccines against infectious diseases where they induce robust immunity in pre-clinical models early phase clinical trials. However, many aspects the basic virology HAdV, including their...