A5055908137- Acoustic Wave Resonator Technologies
- Ultrasonics and Acoustic Wave Propagation
- Mechanical and Optical Resonators
- Analytical Chemistry and Sensors
- Microfluidic and Bio-sensing Technologies
- Advanced MEMS and NEMS Technologies
- Antibiotics Pharmacokinetics and Efficacy
- Growth Hormone and Insulin-like Growth Factors
- Bacterial Infections and Vaccines
- Gas Sensing Nanomaterials and Sensors
- Parkinson's Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Underwater Acoustics Research
- Coenzyme Q10 studies and effects
- Analytical Methods in Pharmaceuticals
- Optical and Acousto-Optic Technologies
- Signaling Pathways in Disease
- Metabolism, Diabetes, and Cancer
- Synthesis of Tetrazole Derivatives
- Mass Spectrometry Techniques and Applications
- Flow Measurement and Analysis
- Nuclear Receptors and Signaling
- Infectious Diseases and Tuberculosis
- Non-Destructive Testing Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
The University of Tokyo
2015-2024
Japanese Red Cross Medical Center
2024
Yokohama Rosai Hospital
2018-2024
National Center for Global Health and Medicine
2019-2022
University of Toledo
2008
Shibaura Institute of Technology
1986-2003
Kansai University
2003
Osaka University
2000
Fujisawa City Hospital
1971-1994
Daiwa Pharmaceutical Co. (Japan)
1971-1993
Glucocerebrosidase gene (GBA) variants that cause Gaucher disease are associated with Parkinson (PD) and dementia Lewy bodies (DLB). To investigate the role of GBA in multiple system atrophy (MSA), we analyzed a large case-control series.We sequenced coding regions flanking splice sites 969 MSA patients (574 Japanese, 223 European, 172 North American) 1509 control subjects (900 315 294 American). We focused solely on Gaucher-disease-causing variants.In Japanese series, found nine carriers...
<h3>Importance</h3> Multiple system atrophy (MSA) is an intractable neurodegenerative disease characterized by autonomic failure in addition to various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. It has recently been reported that functionally impaired variants of<i>COQ2</i>, which encodes essential enzyme the biosynthetic pathway coenzyme Q10 (CoQ10), are associated with MSA. However, little known about role CoQ10 pathogenesis <h3>Objective</h3> To compare...
We report a 3-year follow-up of high-dose ubiquinol supplementation in case familial multiple system atrophy (MSA) with compound heterozygous nonsense (R387X) and missense (V393A) mutations COQ2. A substantially increased total coenzyme Q10 levels cerebrospinal fluid as well plasma. The patient was at the advanced stage MSA, various scores clinical rating scales remained stable without changes during 3 years. cerebral metabolic ratio oxygen measured by 15O2 PET, however, approximately 30%...
The three-dimensional structure of human insulin-like growth factor-I has been determined through a combination NMR measurements and distance geometry calculations. A total 320 interatomic constraints, including 12 related to the disulfide bridges, were used in these resulting is characterized by presence three helical rods corresponding sequence regions, Ala8-Cys18, Gly42-Cys48 Leu54-Cys61. Furthermore, turn an extended exist Gly19-Gly22 Phe23-Asn26 respectively. Neglecting N- C-termini,...
We have established two in vitro bioassay systems for quantification of insulin-like growth factor (IGF) bioactivity. The first assay was used to quantitate mitogenic activity and the second metabolic activity. Both assays use BALB/c 3T3 fibroblasts grown under serum-free conditions; detection bioactivity performed colorimetrically did not require radioisotopes. bioassay, which requires 48 h detection, quantitates changes cell number provides an index determining factors. Changes were...
Abstract To elucidate the molecular basis of multiple system atrophy (MSA), a neurodegenerative disease, we conducted genome-wide association study (GWAS) in Japanese MSA case/control series followed by replication studies Japanese, Korean, Chinese, European and North American samples. In GWAS stage rs2303744 on chromosome 19 showed suggestive ( P = 6.5 × 10 −7 ) that was replicated additional samples 2.9 −6 . OR 1.58; 95% confidence interval, 1.30 to 1.91), then confirmed as highly...
The remarkable vasorelaxant and anti-platelet effects of FK409 have been reported to be due nitric oxide (NO) release. purpose the present study is investigate spontaneous NO-releasing pathway in aqueous solutions. 'H-NMR spectra suggested that compound underwent a time-dependent elimination hydrogen atom at a-position nitro moiety (at 5-position) weakly alkaline In addition, degradation monitored by HPLC showed pH-dependency accelerating with an increase pH. These results revealed first...
Human insulin-like growth factor-I (IGF-I) was studied by two-dimensional 1H-NMR spectroscopy. Resonance assignments were obtained for all the backbone protons and almost of sidechain total 70 amino acid residues, using sequence-specific assignment procedures. The secondary structure elements human IGF-I identified investigation sequential medium range NOEs as a preliminary step in determining three-dimensional this protein means distance geometry calculations. typical d alpha beta(i,i + 3)...
Photovoltaic behavior of the merocyanine dye family with a rhodanine ring has been systematically studied by employing eight different derivatives in diode structure Al/evaporated dye/Ag. Each film behaves like p-type semiconductor rectifying barrier at Al interface and an Ohmic contact Ag electrode. The open circuit photovoltage as high V oc ≃1.5 was observed for one derivatives, while fill factor remained f.f.≃0.25 all cases. chemical stability molecules during after evaporation is also...
ABSTRACT We have examined the biological effects of insulinlike growth factor-binding proteins (IGFBPs) on insulin-like factor (IGF)-activated glucose consumption in a BALB/c 3T3 subline. The method employed was colorimetric measurement consumption, allowing detection changes from initial concentration conditioned medium, following addition IGFs and IGFBPs. Human IGFBP-1, purified amniotic fluid, inhibited IGF-activated although it had no effect insulin-activated consumption. median...
Under the condition of continuous acoustic generation patterns forward, backward, and standing SAW’s propagating on a y-cut z-propagating LiNbO3 crystal were observed clearly by frequency-translated holographic technique. The parameters surface-wave propagation velocity, reflectivity, transmissivity for an interdigital transducer could be obtained this
Abstract: The solution structure of a disulfide bond isomer human insulin‐like growth factor‐I (IGF‐I) was determined using homonuclear NMR methods. A total 292 interatomic distance constraints, including 12 related to the bridges, used in geometry calculations. structures contain two helical rods corresponding sequence regions, Ala 8 –Cys 18 and Leu 54 61 . Comparison with previously native IGF‐I revealed partial correspondence secondary (helices I: helices III: ) internal packing. Helix II...
The polymorphism of a novel and orally effective uricosuric agent, [3-(4-bromo-2-fluorobenzyl)-7-fluoro-2,4-dioxo-1,2,3,4-tetrahydro-quinazolin-1-yl] acetic acid, designated as FR76505, was characterized by X-ray powder diffractometry thermal analysis. In the crystalline state, FR76505 exists in at least three polymorphic forms, Forms A, B C. Among them, Form is stable form, A C which are transformed to metastable forms. not enough keep its state even room temperature. Therefore, it suitable...
AbstractAbstractA collaborative study was carried out by seven different laboratories to evaluate quinine actinometry as a universal, standardized method for calibrating UV radiation intensity from light sources used in light-stability testing of pharmaceutical products. Near fluorescent lamps, white metal halide lamps and xenon arc were employed sources. The increase absorbance at 400 nm aqueous solutions found be proportional the integrated energy emitted linearity observed between...
A one-port resonator utilizing shear horizontal surface acoustic waves (SH-SAWs) has been used for sensing applications in liquids. SH-SAWs have excited on a 36°-rotated Y -cut X -propagating LiTaO 3 substrate using interdigital transducers and the configuration as element The sensitivity of resonance frequency Q value viscosity liquids measured. Experimental results showed that SH-SAW varied with loaded sample liquid.
Abstract A fetal heart sound transducer and an uterine contraction monitor are designed utilizing extended PVDF-film with the transverse effect due to d 31 constant silicone rubber. receiving a transmitting part of array fabricated on film constructing so that frequency response abdominal wall can be detected for each patient. The useful clinical data spectrum have been obtained monitoring is performed.