A5027353873- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Inorganic and Organometallic Chemistry
- Pain Management and Opioid Use
- Cancer therapeutics and mechanisms
- Synthesis of Tetrazole Derivatives
- Microbial Metabolites in Food Biotechnology
- Chemistry and Chemical Engineering
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Reactions
- Potato Plant Research
- Chemical Synthesis and Analysis
- Heavy metals in environment
- Adenosine and Purinergic Signaling
- Bioactive Compounds and Antitumor Agents
- Social Issues and Policies in Latin America
- Psidium guajava Extracts and Applications
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Plant and soil sciences
- Heavy Metal Exposure and Toxicity
- Opioid Use Disorder Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Medical research and treatments
- Environmental Justice and Health Disparities
Universidad Autónoma de Zacatecas "Francisco García Salinas"
2017-2024
The heterocycle ring tetrazole is an important moiety relevant to medicinal chemistry since it present in some drugs with clinical importance. Its primary biological activity being a bioisosteric analogue of the carboxylic acid and cis-amide groups. metabolic stability other physicochemical properties make attractive structure for designing synthesizing new pharmaceuticals. tetrazoles quite extensive includes antiviral, antibacterial, anticancer, antifungal, antioxidant properties; all them...
Abstract Nowadays, the pharmaceutical industry faces challenge of innovating and increasing productivity new medicines due to multidrug resistance among bacteria, viruses fungi. The main objective present study is connected quinolone triazole molecules enhance broad antibacterial spectrum as well have multiple mechanisms action. Preparation 4‐substituted‐1 H ‐1,2,3‐triazol‐1‐yl in C‐7 6‐fluoro‐ 6,8‐difluoro‐quinolone ring showed. synthesis involved preparation intermediate ethyl...
<b><i>Background:</i></b> Fluoroquinolones are widely prescribed synthetic antimicrobial agents. Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome; irreversible DNA damage eventually causes killing of bacteria. Thorough knowledge structure-activity relationship quinolones is essential for development new drugs with improved activity against resistant strains....
Background: Nitroaromatic compounds are important scaffolds used for the syn-thesis of a variety compounds, such as explosives, herbicides, dyes, perfumes and phar-maceuticals. Bismuth nitrate pentahydrate is widely reagent in organic synthesis; how-ever, its utility nitrating agent anilines underexplored. Objective: The aim this work to propose find proper reaction conditions an alternative constituted by mixture bismuth / acetic anhydride DCM with series substituted under mild reflux....
En los agroecosistemas, el suelo es esencial para todos cultivos, siendo principal soporte de las raíces y la fuent-e nutrientes plantas. El además hábitat microorganismos que pueden llegar a tener efectos tanto benéficos como perjudiciales Los suelos supresivos (SS) son quizás mejor ejemplo describir compleja interacción entre plantas su microbioma. un SS incidencia severidad infecciones permanecen bajas aun en condiciones adecuadas desarrollo. Existen dos tipos supresión SS: general, donde...
Los opioides desde hace muchos años son los analgésicos más utilizados y efectivos para el tratamiento del dolor. Este trabajo da a conocer la clasificación farmacológica, usos terapéuticos, riesgos salud reacciones adversas de como fármacos, planteando paradigma usar este tipo fármacos control dolor, sin embargo se han convertido en un problema distintos países ya que ciertas circunstancias tienen alto potencial causar adicción. Además su uso contra antidiarreicos, antitusivos diversas...
A simple and efficient two-step method was implemented for the synthesis of ethyl 7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate. Comparing with reported Grohe-Heitzer reaction, time reaction steps have been reduced using microwave irradiation. This compound is an important intermediate preparation naphthyridone derivatives which received significant attention due to their broad spectrum biological activity.