A5045626133- Synthesis and Biological Evaluation
- Chemical Reactions and Mechanisms
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Chemistry and Chemical Engineering
- Cancer therapeutics and mechanisms
- Chemical Reaction Mechanisms
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Morinda citrifolia extract uses
- Phenothiazines and Benzothiazines Synthesis and Activities
- Garlic and Onion Studies
- Click Chemistry and Applications
- Organic Chemistry Cycloaddition Reactions
- Mesoporous Materials and Catalysis
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Plant-derived Lignans Synthesis and Bioactivity
- Essential Oils and Antimicrobial Activity
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Synthesis of Tetrazole Derivatives
- Synthesis of β-Lactam Compounds
Autonomous University of San Luis Potosí
2014-2025
Université Laval
2022
Institute for Biomedical and Pharmaceutical Research
2022
University of Bonn
2022
The University of Texas MD Anderson Cancer Center
2022
UCLouvain
2022
University of California, Los Angeles
2012-2013
The photoinduced and thermal denitrogenation of crystalline triazolines with bulky substituents leads to the quantitative formation aziridines in clean solid-to-solid reactions despite very large structural changes transition from reactant product. Analysis reaction progress by powder X-ray diffraction, solid-state (13)C CPMAS NMR, FTIR spectroscopy, analysis has revealed that proceed either through metastable phases susceptible amorphization or mechanisms involve a reconstructive phase...
A new synthetic strategy to obtain linked 1,5-disubstituted tetrazole-1,2,3-triazoles via the Ugi-azide reaction followed by a copper-catalyzed alkyne-azide (CuAAC) was developed. This used solvent-free conditions for reaction. two-step affords products in moderate good yields. To best of our knowledge, this is first report using CuAAC as post-condensation process an and therefore, describing synthesis tetrazole (1,5-DS-T) 1,2,3-triazole moiety, which are molecules that may have potential...
The solid-state photodenitrogenation of crystalline triazolines proceeds with high efficiency to form the corresponding aziridines in chemical yields upon selection proper irradiation wavelength. It was shown that solid-to-solid reactions occur by formation product metastable phases.
We performed an extensive analysis about the reaction conditions of 1,4-Michael addition amino acids to 1,4-naphthoquinone and substitution 2,3-dichloronaphthoquinone, a complete evaluation stoichiometry, use different bases, pH influence was performed. were able show that microwave-assisted synthesis is best method for naphthoquinone–amino acid chloride–naphthoquinone–amino derivatives with 79–91% 78–91% yields, respectively. The cyclic voltammetry profiles showed both series mainly display...
We previously showed that microwave assisted synthesis is the best method for of naphthoquinone amino acid and chloride-naphthoquinone derivatives by a complete evaluation reaction conditions such as stoichiometry, bases, pH influence. Following same strategy, we synthesized chloride non-chloride tyrosine, valine, tryptophan-naphthoquinones achieving 85–95%, 80–92%, 91–95% yields, respectively. The cyclic voltammetry profiles both series mainly display one redox process. Overall, exhibited...
Snow mountain garlic is traditionally eaten by Himalayan locals for its medicinal properties. Although different species of the genus
<b><i>Background:</i></b> Fluoroquinolones are widely prescribed synthetic antimicrobial agents. Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome; irreversible DNA damage eventually causes killing of bacteria. Thorough knowledge structure-activity relationship quinolones is essential for development new drugs with improved activity against resistant strains....
Mannich bases are formed in a noncatalytic multicomponent reaction, which is promoted by ultrasound irradiation. The procedure avoids the use of toxic solvents, catalyst, and purification, generating desired compounds excellent yields short reaction times.
Heterogeneous photocatalysis is widely used in a broad variety of chemical reactions such as oxidations, dehydrogenation and hydrogen transfer. The photocatalyzed reduction nitro groups has been to prepare organic compounds with important industrial biological applications. formation the desired compound could be controlled by selecting adequate reaction conditions catalyst solvent. This review presents overview mechanisms photocatalytic nitrobenzene develop viable route produce sole or...
The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, synthesis their derivatives to review considering philosophy green chemistry. In this review, we present actual importance hydantoins using methods, microwave ultrasound irradiation, ionic liquids, solid-phase solvent-free synthesis. Finally, protocols reported...
The nitrogen inversion of a N-phenyl aziridine fused to succinimide ring is influenced by the presence phenyl in moiety. endo invertomer favored, showing an unsymmetrical equilibrium variable (1)H NMR studies.
1,4-naftoquinone (NQ) molecules have been extensively evaluated as potent antibacterial compounds; however, their use is limited, since they low water solubility and exhibit toxicities in healthy eukaryotic cells. A possible path to overcoming these challenges the of particulate vehicles, such SBA-15, which a biocompatible biodegradable mesoporous silica material, that may enhance drug delivery decrease dosages. In this work, an isotherm model-based adsorption three NQs into SBA-15...
The synthesis and biological evaluation of 1,4-naphthoquinone derivatives are great interest since these compounds exhibit strong antibacterial, antifungal, antimalarial, anticancer activities. electronic properties naphthoquinones usually modulated by attaching functional groups containing nitrogen, oxygen sulfur atoms, which tune their potency selectivity.A series 13 amino acid were synthesized under assisted microwave ultrasound conditions. antibacterial activity was tested against...