A5072045803- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Chemical synthesis and alkaloids
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Asymmetric Synthesis and Catalysis
- Alkaloids: synthesis and pharmacology
- Synthesis and Biological Activity
- Natural product bioactivities and synthesis
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Phytochemistry and Biological Activities
- Porphyrin and Phthalocyanine Chemistry
- Radical Photochemical Reactions
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Carbon dioxide utilization in catalysis
- Sesquiterpenes and Asteraceae Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Axial and Atropisomeric Chirality Synthesis
- Plant biochemistry and biosynthesis
Universidad Veracruzana
2021-2024
Instituto de Ecología
2023
Benemérita Universidad Autónoma de Puebla
2015-2019
Universidad Autónoma Metropolitana
2016-2018
Universidad Nacional Autónoma de México
2009-2014
The present work reports the first example of use chemistry radical cations under nonoxidative conditions in total synthesis. Using a late-stage tandem radical/polar crossover reaction, highly stereoselective synthesis cephalosporolide E (which is typically obtained admixed with F) was accomplished. reaction phthalimido derivative triphenyltin refluxing toluene engenders contact ion-pair (radical cation) that leads, instance, to F, which transformed into via stereocontrolled spiroketal...
Here we report a seven-step protecting-group-free stereoselective total synthesis of the elusive (+)-cephalosporolide F from d-glucose. A microwave-assisted reaction between Meldrum's acid and d-glucose to respective octono-1,4-lactone derivative, low temperature visible-light photoredox spirocyclization chiral N-alkoxyphthalimide ceph F, are two key chemical reactions that allowed accomplishment this unprecedented feat under an environmentally friendly processes.
The stereocontrolled synthesis of naturally occurring products containing a 5,5-spiroketal molecular structure represents major synthetic problem. Moreover, in previous work, the cephalosporolide E (ceph E), which presumably was obtained from its epimer congener F) through an acid-mediated equilibration process, reported. Consequently, we performed theoretical investigation to provide relevant information regarding title question, and it found that higher thermodynamic stability ceph E,...
Two strategies for the synthesis of gilvocarcins were explored in order to construct <i>C</i>-arylglycosidic tricyclic core these natural products. Whereas addition a complex naphthalene onto carbohydrate-derived lactone, following Kishi’s protocol failed, key <i>C</i>-glycosidic bond was successfully forged regio- and stereoselective manner through use TMS-acetylide as nucleophile. Conversion alkyne into diene Diels–Alder cycloaddition with an situ generated quinone allowed assembling...
A cascade Diels-Alder reaction coupled with an oxidative aromatization was developed and applied to a chiral 2-pyrone for the synthesis of relevant synthon/chiral auxiliary (-)-cis-aminoindan-2-ol. Chirality optical purity were provided by privileged chiron 7,3-LXF.
Background: Salvia urica Epling is taxonomically and phylogenetically related to amarissima Ortega. The last species has pharmacological relevance by its contents of bioactive metabolites. Nowadays, no reports about chemical constituents activities. Hypothesis: Does the close relationship between S. led both produce similar specialized metabolites? display effects as amarissima? Studied species: (Lamiaceae). Study site dates: plant material was collected in Teopisca, Chiapas, Mexico,...