A5079205155- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Ocular Diseases and Behçet’s Syndrome
- Piperaceae Chemical and Biological Studies
- Advanced Chemical Sensor Technologies
- Ubiquitin and proteasome pathways
- Essential Oils and Antimicrobial Activity
- Plant tissue culture and regeneration
- Bioactive Compounds and Antitumor Agents
- Trace Elements in Health
- HIV Research and Treatment
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Forensic and Genetic Research
- Electrochemical sensors and biosensors
- Biochemical Analysis and Sensing Techniques
- Plant biochemistry and biosynthesis
Universidade Estadual Paulista (Unesp)
2007-2022
Instituto de Tecnología Química
2020
Universidade de São Paulo
2007
As part of a bioprospecting program aimed at the discovery antiprotozoal agents from Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with known alkaloids aquifoliunine E-I (3) mayteine (4), were isolated root bark Maytenus ilicifolia. The structures 1 2 established on basis spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro activity against Leishmania chagasi Trypanosoma cruzi, IC50 values 1.4 41.9 μM, respectively, as...
Fungal infections in humans have increased alarmingly recent years, particularly immunocompromised individuals. Among the systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent severe humans. The current high incidence of dermatophytosis is humans, especially as main etiologic agents Trichophyton rubrum mentagrophytes . Molecules pristimerin maytenin obtained from plant Maytenus ilicifolia (Celastraceae) known to show...
Abstract Among the biologically active triterpenes, friedelin has most-rearranged structure produced by oxidosqualene cyclases and is only one containing a cetonic group. In this study, we cloned functionally characterized synthase cycloartenol from Maytenus ilicifolia (Celastraceae). The complete coding sequences of these 2 genes were leaf mRNA, their functions heterologous expression in yeast. sequence very similar to other known OSCs type (approximately 80% identity), although M. amino...
Compounds extracted from plants can provide an alternative approach to new therapies. They present characteristics such as high chemical diversity, lower cost of production and milder or inexistent side effects compared with conventional treatment. The Brazilian flora represents a vast, largely untapped, resource potential antiviral compounds. In this study, we investigate the panel natural compounds isolated species on hepatitis C virus (HCV) genome replication. To do used firefly...
Establishment of adventitious root cultures Peritassa campestris (Celastraceae) was achieved from seed cotyledons cultured in semisolid Woody Plant Medium (WPM) supplemented with 2% sucrose, 0.01% PVP, and 4.0 mg L −1 IBA. Culture period on accumulation biomass quinone-methide triterpene maytenin were investigated. The these roots compared its the seedlings grown a greenhouse (one year old). A rapid detection identification by direct injection into an atmospheric-pressure chemical ionization...
Abstract The voltammetric determination of rutin in 0.04 mol l−1 B‐R buffer (pH 4.0) by square wave voltammograms (+0.41 V vs. Ag/AgCl(sat.)) at a poly glutamic acid modified glassy carbon electrode was found to be several orders magnitude lower than that on bare electrode. Rutin can preconcentrated the films and presented linear relationship from concentration 7×10−7 1×10−5 pH 4.0. method successfully applied pharmaceutical formulation without any pretreatment.
Maytenus ilicifolia (Celastraceae) is a medicinal plant that native to southern Brazil and popularly known as "espinheira-santa".From biosynthesis perspective, this species accumulates quinonemethide triterpenes sesquiterpene pyridine alkaloids major secondary metabolites exhibit interesting biological properties, with antitumoral antiprotozoal activities, respectively, being the most frequently reported.Additionally, restricted accumulation of such compounds in roots raises questions about...
Maytenus ilicifolia is an important plant with a great potential for cancer treatment and has popular diffused use, as tea, in Brazil other countries against gastric ulcers, dyspepsia others problems. In this paper, the antioxidant anti-radical activities of were compared trolox uric acid by their abilities scavengers DPPH·, ABTS·+, O2·-, HOCl NO. all systems, significant correlation existed between concentration extracts percentage inhibition free radicals. Moreover, these could inhibit...