A5034567632- Alzheimer's disease research and treatments
- Electrospun Nanofibers in Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- 14-3-3 protein interactions
- Amyotrophic Lateral Sclerosis Research
- Therapeutic Uses of Natural Elements
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
- Silk-based biomaterials and applications
- Osteoarthritis Treatment and Mechanisms
- Iron oxide chemistry and applications
- Clay minerals and soil interactions
- Mass Spectrometry Techniques and Applications
- Medicinal Plants and Neuroprotection
- Advanced Sensor and Energy Harvesting Materials
- Neuropeptides and Animal Physiology
- Conducting polymers and applications
- Molecular Sensors and Ion Detection
- Renin-Angiotensin System Studies
- Supramolecular Self-Assembly in Materials
Weill Cornell Medicine
2021-2024
Cornell University
2021-2024
Rensselaer Polytechnic Institute
2018-2019
High-performance cellulose–halloysite hemostatic nanocomposite fibers (CHNFs) are fabricated using a one-step wet–wet electrospinning process and evaluated for human plasma coagulation by activated partial thromboplastin time. These novel biocompatible CHNFs exhibit 2.4 times faster time compared with the industry gold standard QuikClot Combat Gauze (QCG). The have superior antileaching property of clay 3 higher post-wetting clotting activity to QCG. also coagulate whole blood 1.3 than QCG...
Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer's disease (AD), but detection Aβ is a persistent challenge. Herein, we engineered near-infrared optical nanosensor capable detecting intracellularly live cells and intracranially vivo. The sensor composed single-walled carbon nanotubes functionalized with wherein Aβ-Aβ interactions drive response. We found that nanosensors selectively responded to via solvatochromic modulation emission nanotube. tracked accumulation and,...
Post-translationally modified tau is the primary component of neurofibrillary tangles, a pathological hallmark Alzheimer's disease and other tauopathies. Post-translational modifications (PTMs) within microtubule (MT)-binding domain (MBD), which encompasses two hexapeptide motifs that act as critical nucleating regions for aggregation, can potentially modulate aggregation well interactions with MTs membranes. Here, we characterize effects recently discovered PTM, lysine succinylation, on...
G protein–coupled receptors (GPCRs) control intracellular signaling cascades via agonist-dependent coupling to transducers including heterotrimeric proteins, GPCR kinases (GRKs), and arrestins. In addition their critical interactions with the transmembrane core of active GPCRs, all three classes have also been reported interact receptor C-terminal domains (CTDs). An underexplored aspect CTDs is possible role as lipid sensors given proximity membrane. CTD–membrane potential accessibility key...
CHCHD10 is mutated in rare cases of FTD and ALS aggregates mouse models disease. Here we show that the disordered N-terminal domain forms amyloid fibrils report their cryoEM structure. Disease-associated mutations cannot be accommodated by WT fibril structure, while sequence differences between CHCHD2 are tolerated, explaining co-aggregation two proteins linking to neurodegeneration.
Abstract G protein-coupled receptors (GPCRs) control intracellular signaling cascades via agonist-dependent coupling to transducers including heterotrimeric proteins, GPCR kinases (GRKs), and arrestins. In addition their critical interactions with the transmembrane core of active GPCRs, all three classes have also been reported interact receptor C-terminal domains (CTDs). An underexplored aspect CTDs is possible role as lipid sensors given proximity membrane. CTD-membrane potential...
Abstract Background Amyloid beta (Aß) extracellular deposits are one of the pathohistological hallmarks Alzheimer’s Disease (AD). In recent years intracellular accumulation Aß has been linked with early pathogenic mechanisms. Recent reports now associate Aβ accumulation, and lysosomal disfunction as an event in disease, preceding amyloid‐deposits. Today methods to visualize rely on antibody staining or pre‐labeled Aβ. There is outstanding need for live‐imaging tools capable monitoring...