A5049196382- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Viral Infections and Vectors
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cytomegalovirus and herpesvirus research
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Virus-based gene therapy research
Institut Necker Enfants Malades
2016-2021
Université Paris Cité
2016-2021
Inserm
2015-2021
Centre National de la Recherche Scientifique
2021
Oestrogen receptor-negative (ER-) breast cancer is intrinsically sensitive to chemotherapy. However, tumour response often incomplete, and relapse occurs with high frequency. The aim of this work was analyse the molecular characteristics residual tumours early chemotherapy in patient-derived xenografts (PDXs) cancer.Gene protein expression profiles were analysed a panel ER- PDXs before after treatment. Tumour stromal interferon-gamma measured lysates by human mouse cytokine arrays,...
// Julie Gaston 1, 2 , Laura Cheradame Vanessa Yvonnet Olivier Deas Marie-France Poupon Jean-Gabriel Judde Stefano Cairo 2, 3, * Vincent Goffin 1 Inserm, U1151, Institut Necker Enfants Malades (INEM), University Paris Descartes, Faculty of Medicine, Paris, France XenTech, 4 rue Pierre Fontaine, 91000 Evry, 3 LTTA Center, Department Morphology, Surgery and Experimental Ferrara, Italy These authors contributed equally to this work Correspondence to: Goffin, email: vincent.goffin@inserm.fr...
Abstract Because of their favorable properties as macromolecular drugs, antibodies are a very successful therapeutic modality for interfering with disease-relevant targets in the extracellular space or at cell membrane. However, large number diseases involve cytosolic and designing able to efficiently reach intracellular compartments would expand antibody-tractable conditions. Here, we genetically fused penetrating peptides (CPPs) various positions an antibody targeting cancer cells,...
Abstract STING (Stimulator of Interferon Genes) is a well-known endoplasmic reticulum-anchored adaptor the innate immunity that triggers expression inflammatory cytokines in response to pathogen infection. In cancer cells, this pro-inflammatory pathway can be activated by genomic DNA damage potentiating antitumor immune responses. Here we report promotes cell survival and resistance genotoxic treatment cell-autonomous manner. Mechanistically, show partly localizes at inner nuclear membrane...
Abstract Identification of the mechanisms tumor resistance remains an unmet need in oncology. Among reasons for this challenging issue is lack reliable preclinical models that represent inter and intra-patient heterogeneity observed clinic. Patient-derived xenografts (PDXs) consist grafting human cancer samples into immunocompromised mice directly after patient surgery. Since each PDX faithfully recapitulates patient's genetics, these well intrinsic cancer. We took advantage large collection...
Abstract Triple negative breast cancer (TNBC) accounts for approximately 15-25% of cancers at diagnosis, and is one the most aggressive subtypes, with around 70% patients that live free disease 5 years post-diagnosis. One reliable predictive markers patient outcome pathological complete response (pCR), no tumor cells detectable histopathological level after neoadjuvant chemotherapy. As pCR observed in only about 20-30% TNBC, it mandatory to identify new therapeutic options improve rate upon...
Abstract One of the current tumor immunotherapy strategies involves use STING agonist, a well-known inducer interferon (IFN) signaling in immune system, to promote tumor-rejection. However, recent evidence also indicates that constitutive activation IFN may lead bad outcome. For instance, increased expression IFN- stimulated genes (ISGs) at time surgery was associated with early breast cancer recurrence, and an IFN-related DNA damage resistance signature (IRDS) identified as predictive...
Abstract Several studies have recently indicated the activation of immune system against tumor cells as well targeting cancer cell DNA damage repair mechanisms effective strategies to target growth. STING is a well-known sensor innate immunity mostly characterized transmembrane protein various cytoplasmic organelles that senses cytosolic danger signal and triggers inflammatory responses. A current immunotherapy strategy relies on use agonists boost patient's through cytokine-mediated...