A5044628363- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Manufacturing Process and Optimization
- Cancer, Hypoxia, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Model-Driven Software Engineering Techniques
- Uterine Myomas and Treatments
- NF-κB Signaling Pathways
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Anesthesia and Neurotoxicity Research
- Simulation Techniques and Applications
- Tracheal and airway disorders
- Data Visualization and Analytics
- Metabolism, Diabetes, and Cancer
Tokyo Metropolitan University
2022-2024
Osaka Metropolitan University
2022-2024
Osaka City University Hospital
2024
National Cancer Center Hospital East
2019-2023
Berurando General Hospital
2022
London Health Sciences Centre
2011-2019
Hokkaido University
2016
Nagoya University
2012-2016
Aichi Institute of Technology
2016
Western University
1994-2015
Topotecan has single-agent activity in recurrent ovarian cancer. It was evaluated a novel combination compared with standard frontline therapy.Women aged 75 years or younger newly diagnosed stage IIB greater cancer, Eastern Cooperative Oncology Group Performance Status of 1 less, were stratified by type primary surgery and residual disease, treatment center, age; then randomly assigned to one the two 21-day intravenous regimens. Patients arm (n = 409) administered four cycles cisplatin 50...
Epithelial-mesenchymal transition (EMT) serves as a key mechanism driving tumor cell migration, invasion, and metastasis in many carcinomas. Transforming growth factor-beta (TGFβ) signaling is implicated several steps during cancer pathogenesis acts classical inducer of EMT. Since epithelial ovarian (EOC) cells have the potential to switch between mesenchymal states metastasis, we predicted that modulation TGFβ would significantly impact EMT malignant EOC spheroid cells. Ovarian patient...
// Teresa Peart 1, 2 , Yudith Ramos Valdes 1 Rohann J. M. Correa 3 Elena Fazio Monique Bertrand 4, 5 Jacob McGee 4 Michel Préfontaine Akira Sugimoto Gabriel E. DiMattia 3, Trevor G. Shepherd 2, Translational Ovarian Cancer Research Program, London Regional London, Ontario, Canada Departments of Anatomy & Cell Biology, Schulich School Medicine Dentistry, The University Western Biochemistry, Obstetrics Gynaecology, Oncology, Correspondence to: Shepherd, e-mail: tshephe6@uwo.ca Keywords:...
Abstract STAT5 molecules are key components of the IL-2 signaling pathway, deficiency which often results in autoimmune pathology due to a reduced number CD4+CD25+ naturally occurring regulatory T (Treg) cells. One consequences IL-2-STAT5 axis is up-regulation FOXP3, master control gene for Treg However, roles other subsets have not yet been elucidated. We recently demonstrated that enhanced IL-10 production through activation. This occurred two types human cells: novel type umbilical cord...
To present a new method for closing tympanic membrane perforations using basic fibroblast growth factor (bFGF) combined with an atelocollagen/silicone bilayer as patch material.Closure of was attempted bFGF, which is thought to facilitate the fibroblasts and collagen fibers at margin perforation.Under operating microscope, perforation trimmed, piece infiltrated 0.2 mL Trafermin (0.1% solution) (bFGF group) or saline (control then placed in silicon layer facing outward. Nine patients were...
Abstract Background We aimed to identify the relationship between thyroid transcription factor‐1 (TTF‐1) expression of lung adenocarcinoma and efficacy immune‐checkpoint inhibitor (ICI) therapy. Methods This retrospective multicenter study comprised patients with advanced treated ICI monotherapy. collected clinical medical records including data on TTF‐1 analyzed programmed death‐ligand 1 tumor proportion score (PD‐L1 TPS), objective response rate (ORR), progression‐free survival (PFS),...
Background/Aim: There is no real-world data in an Asian population to investigate the difference between outcome of immune-checkpoint inhibitor (ICI) monotherapy and combination therapy for non-small cell lung cancer (NSCLC) based on smoking status. In this study, we investigated correlation status efficacy ICI NSCLC patients. Patients Methods: This multicentre retrospective study enrolled patients with recurrent or metastatic who were treated using December 2015 July 2020. We analysed...
Adjuvant therapy of early-stage uterine papillary serous carcinoma (UPSC) and clear cell (CCC) is controversial. We conducted a prospective cohort study to evaluate outcomes patients with UPSC or CCC who were followed without adjuvant after complete surgical staging. From 2000 2006, we evaluated all consecutive stage IA/IB had staging by gynecological oncologist at the London Health Sciences Centre, Canada. Follow-up consisted history physical examination every 3 months for 2 years, then 6...
In order to meet a clinical need for better pathways access genetic testing ovarian cancer patients, we implemented and reviewed an opt-out referral process consultation whereby is automatically sent genetics following pathological diagnosis of HGSC. Following implementation the process, each month list new cases HGSC was generated from synoptic pathology report forwarded directly Cancer Genetics clinic. Using advanced directive, patients were referred counselling two months after surgery....